Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nitin T. Aggarwal"'
Publikováno v:
Channels. 7:493-502
Cardiac ATP-sensitive potassium channels (KATP) are found in both the sarcoplasmic reticulum (sarcKATP) and the inner membrane of mitochondria (mitoKATP). SarcKATP are composed of a pore containing subunit Kir6.2 and a regulatory sulfonylurea recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c92306ddeb33ae50d95988798791da
https://doi.org/10.4161/chan.26181
https://doi.org/10.4161/chan.26181
Autor:
Elizabeth M. McNally, Nitin T. Aggarwal, Stacie Kroboth, Jie Lin Pu, Jonathan C. Makielski, J. Jason Sims, Nian Qing Shi, Bin Ye
Publikováno v:
Circulation Research. 105:1083-1093
Rationale : Cardioprotective pathways may involve a mitochondrial ATP-sensitive potassium (mitoK ATP ) channel but its composition is not fully understood. Objective : We hypothesized that the mitoK ATP channel contains a sulfonylurea receptor (SUR)2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b020837b88790ad989cd6ff5ec606d
https://doi.org/10.1161/circresaha.109.195040
https://doi.org/10.1161/circresaha.109.195040
Publikováno v:
Federal Register
Objective— Arachidonic acid (AA) metabolites from 15-lipoxygenase-1 (15-LO-1), trihydroxyeicosatrienoic acid (THETA), and hydroxyepoxyeicosatrienoic acid (HEETA) relax arteries. We studied 15-LO-1 expression, THETA and HEETA synthesis, and their ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4e4510e4b02b4e58ffa1337e1b1774
https://doi.org/10.1161/atvbaha.108.177113
https://doi.org/10.1161/atvbaha.108.177113
Autor:
Douglas Stoller, Babatunde A. Yerokun, Judy U. Earley, Nian Qing Shi, Michele Hadhazy, Elizabeth M. McNally, Gene Kim, Jonathan C. Makielski, John Fahrenbach, Nitin T. Aggarwal
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(7)
The newborn heart adapts to postnatal life by shifting from a fetal glycolytic metabolism to a mitochondrial oxidative metabolism. Abcc9, an ATP-binding cassette family member, increases expression concomitant with this metabolic shift. Abcc9 encodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622b17f6a1d020d801886ba9c204c1e3
https://pubmed.ncbi.nlm.nih.gov/24648545
https://pubmed.ncbi.nlm.nih.gov/24648545
Reactive oxygen species (ROS) have been associated with various human diseases, and considerable attention has been paid to investigate their physiological effects. Various ROS are synthesized in the mitochondria and accumulate in the cytoplasm if th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bc4346e4f9b12c71d78fa54ee28616
https://europepmc.org/articles/PMC3526898/
https://europepmc.org/articles/PMC3526898/
Autor:
Nitin T. Aggarwal, Guido Grassi
Publikováno v:
Journal of hypertension. 30(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f084d57523195d8b171040f9eaabe1b
https://pubmed.ncbi.nlm.nih.gov/22245986
https://pubmed.ncbi.nlm.nih.gov/22245986
Endothelial 15-lipoxygenase-1 (15-LO-1) metabolites of arachidonic acid (AA), 11,12,15-trihydroxyeicosatrienoic acid (THETA) and 15-hydroxy-11,12-epoxyeicosatrienoic acid (HEETA) and nitric oxide (NO) mediate relaxations to acetylcholine (ACH). Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3aff75f7a4c9d54c1f14bdbe73b60ba
https://europepmc.org/articles/PMC3268834/
https://europepmc.org/articles/PMC3268834/
Autor:
Nitin T. Aggarwal, John R. Falck, Kathryn M. Gauthier, Yuttana Chawengsub, William B. Campbell, Daniel Goldman
Arachidonic acid (AA) metabolites function as EDHFs in arteries of many species. They mediate cyclooxygenase (COX)- and nitric oxide (NO)-independent relaxations to acetylcholine (ACh). However, the role of AA metabolites as relaxing factors in mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6aa74472725009b21b2edb62b8f4e26
https://europepmc.org/articles/PMC3064304/
https://europepmc.org/articles/PMC3064304/
Autor:
Zeljko J. Bosnjak, Nitin T. Aggarwal, Nian Qing Shi, Danijel Pravdic, Jonathan C. Makielski, Elizabeth M. McNally
The sulfonylurea receptor-2 (SUR2) is a subunit of ATP-sensitive potassium channels (KATP) in heart. Mice with the SUR2 gene disrupted (SUR2m) are constitutively protected from ischemia-reperfusion (I/R) cardiac injury. This was surprising because KA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680b46761ffa7e234639a2015e5c4ee2
https://europepmc.org/articles/PMC3006279/
https://europepmc.org/articles/PMC3006279/
Autor:
Douglas Stoller, Michele Hadhazy, Elizabeth M. McNally, Jamie Metcalfe, John Fahrenbach, Bi-Hua Tan, Nian Qing Shi, Nitin T. Aggarwal, Karel Chalupsky, Jonathan C. Makielski
Sulfonylurea receptor-containing ATP-sensitive potassium (KATP) channels have been implicated in cardioprotection, but the cell type and constitution of channels responsible for this protection have not been clear. Mice deleted for the first nucleoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d8bf45067c406c23df6f08922624a0
https://europepmc.org/articles/PMC2957346/
https://europepmc.org/articles/PMC2957346/