Výsledky vyhledávání - "Nitin S Sekhar"

Akademický článek

A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice

Autor: Joseph Ray Cepeda, Nitin S Sekhar, Junying Han, Wei Xiong, Ningyan Zhang, Liping Yu, Shaodong Dai, Howard W. Davidson, John W. Kappler, Zhiqiang An, Li Zhang

Publikováno v: mAbs, Vol 12, Iss 1 (2020)

Activation of T cells specific for insulin B chain amino acids 9 to 23 (B:9–23) is essential for the initiation of type 1 diabetes (T1D) in non-obese diabetic mice. We previously reported that peptide/MHC complexes containing optimized B:9–23 mim

Externí odkaz: https://doaj.org/article/72ce24d0357c4b38886ed579e0584dd3

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A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice

Autor: John W. Kappler, Joseph Ray Cepeda, Liping Yu, Wei Xiong, Shaodong Dai, Li Zhang, Junying Han, Howard W. Davidson, Ningyan Zhang, Nitin S Sekhar, Zhiqiang An

Publikováno v: mAbs
article-version (VoR) Version of Record

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd18c2c2afb9ec3853f2b2dee9daae0
https://doi.org/10.1080/19420862.2020.1836714

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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Autor: Joseph Ray Cepeda, Ling Gao, Junying Han, Nitin S Sekhar, Howard W. Davidson, Tomasz Sosinowski, Li Zhang

Publikováno v: Journal of Visualized Experiments.

Type 1 Diabetes (T1D) is characterized by islet-specific autoimmunity leading to beta cell destruction and absolute loss of insulin production. In the spontaneous non-obese diabetes (NOD) mouse model, insulin is the primary target, and genetic manipu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6288ef3debfc0759e956cdb41dd6a84a
https://doi.org/10.3791/59985-v

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92-OR: Using Bispecific Monoclonal Antibody to Reprogram the Development of Type 1 Diabetes

Autor: Joseph Ray Cepeda, Massimo Pietropaolo, Junying Han, Ningyan Zhang, Li Zhang, Nitin S Sekhar

Publikováno v: Diabetes. 68

Background: In NOD mice, insulin B:9-23 peptide bound to I-Ag7 in an energy unfavorable register 3 (R3) forms the antigenic I-Ag7/B:9-23(R3) complex. Previously we demonstrated that I-Ag7/B:9-23(R3) specific monoclonal antibody mAb287 delayed T1D. Su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87da7eba43f29d9a0567405417c1d49c
https://doi.org/10.2337/db19-92-or

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Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes

Autor: Joseph Ray Cepeda, Tomasz Sosinowski, Liping Yu, Li Zhang, Howard W. Davidson, Sean M. Hartig, Dongmei Miao, Nitin S Sekhar, Aaron R. Cox, Massimo Pietropaolo

A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9–23 peptide can bind to the NOD MHC class II molecule (I-A(g7)) in multiple registers, but only one, (registe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be8e4480f3f4fa81847b8bb7c228ab8
https://europepmc.org/articles/PMC6541442/

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