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Akademický článek

ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer

Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 8, Pp 1-17 (2023)

Abstract Small‐cell lung cancer (SCLC) is the most lethal type of lung cancer. Specifically, MYC‐driven non‐neuroendocrine SCLC is particularly resistant to standard therapies. Lurbinectedin was recently approved for the treatment of relapsed S

Externí odkaz: https://doaj.org/article/6165ccece4b14143846203745ec9358e

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Akademický článek

Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells.

Externí odkaz: https://doaj.org/article/9bbad19d5fd14d8c895c04b8d779aa1f

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Akademický článek

Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models

Autor: Delphine Lissa, Nobuyuki Takahashi, Parth Desai, Irena Manukyan, Christopher W. Schultz, Vinodh Rajapakse, Moises J. Velez, Deborah Mulford, Nitin Roper, Samantha Nichols, Rasa Vilimas, Linda Sciuto, Yuanbin Chen, Udayan Guha, Arun Rajan, Devon Atkinson, Rajaa El Meskini, Zoe Weaver Ohler, Anish Thomas

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Molecular subtypes of small cell lung cancer characterized by neuroendocrine differentiation have been described in cell lines and primary tumors. The clinical implications of neuroendocrine subtypes in metastatic and relapsed tumors, and the extent

Externí odkaz: https://doaj.org/article/2b706f2be3074f5d81c7957af90cea3c

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Akademický článek

Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

Autor: Lorinc S. Pongor, Camille Tlemsani, Fathi Elloumi, Yasuhiro Arakawa, Ukhyun Jo, Jacob M. Gross, Sara Mosavarpour, Sudhir Varma, Rahul K. Kollipara, Nitin Roper, Beverly A. Teicher, Mirit I. Aladjem, William Reinhold, Anish Thomas, John D. Minna, Jane E. Johnson, Yves Pommier

Publikováno v: iScience, Vol 25, Iss 11, Pp 105338- (2022)

Summary: DNA methylation is a key regulator of gene expression and a clinical therapeutic predictor. We examined global DNA methylation beyond the generally used promoter areas in human small cell lung cancer (SCLC) and find that gene body methylatio

Externí odkaz: https://doaj.org/article/a17e396cdddf482889e621906481c5ce

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Akademický článek

Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

Autor: Nitin Roper, Moises J. Velez, Alberto Chiappori, Yoo Sun Kim, Jun S. Wei, Sivasish Sindiri, Nobuyuki Takahashi, Deborah Mulford, Suresh Kumar, Kris Ylaya, Christopher Trindade, Irena Manukyan, Anna-Leigh Brown, Jane B. Trepel, Jung-Min Lee, Stephen Hewitt, Javed Khan, Anish Thomas

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC) and the mechanisms driving benefit are poorly understood. Here, the authors show that elevated Notch signaling predicts clinical benefit in I

Externí odkaz: https://doaj.org/article/14cd7395b4e240a6a4c5e9753ff63101

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Akademický článek

SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

Autor: Camille Tlemsani, Lorinc Pongor, Fathi Elloumi, Luc Girard, Kenneth E. Huffman, Nitin Roper, Sudhir Varma, Augustin Luna, Vinodh N. Rajapakse, Robin Sebastian, Kurt W. Kohn, Julia Krushkal, Mirit I. Aladjem, Beverly A. Teicher, Paul S. Meltzer, William C. Reinhold, John D. Minna, Anish Thomas, Yves Pommier

Publikováno v: Cell Reports, Vol 33, Iss 3, Pp 108296- (2020)

Summary: CellMiner-SCLC (https://discover.nci.nih.gov/SclcCellMinerCDB/) integrates drug sensitivity and genomic data, including high-resolution methylome and transcriptome from 118 patient-derived small cell lung cancer (SCLC) cell lines, providing

Externí odkaz: https://doaj.org/article/c3a89008a1ef48f497155a5b22995bc3

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Akademický článek

Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer

Publikováno v: Cell Reports Medicine, Vol 1, Iss 1, Pp 100007- (2020)

Summary: Clonal evolution of osimertinib-resistance mechanisms in EGFR mutant lung adenocarcinoma is poorly understood. Using multi-region whole-exome and RNA sequencing of prospectively collected pre- and post-osimertinib-resistant tumors, including

Externí odkaz: https://doaj.org/article/bd88b4540b1e47469281d9cfc6d07cbc

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Akademický článek

APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors

Publikováno v: Cell Reports, Vol 26, Iss 10, Pp 2651-2666.e6 (2019)

Summary: Intratumor mutational heterogeneity has been documented in primary non-small-cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using

Externí odkaz: https://doaj.org/article/a89fb160e8244d76991306067b2f929e

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