Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Nitin Pal Kalia"'
Autor:
Priya Ragunathan, Pearly Shuyi Ng, Samsher Singh, Wee Han Poh, Dennis Litty, Nitin Pal Kalia, Simon Larsson, Amaravadhi Harikishore, Scott A. Rice, Philip W. Ingham, Volker Müller, Garrett Moraski, Marvin J. Miller, Thomas Dick, Kevin Pethe, Gerhard Grüber
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT The Mycobacterium tuberculosis (Mtb) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and discov
Externí odkaz:
https://doaj.org/article/326a564021ea4d0fb1574e9e794a038f
Autor:
Nitin Pal Kalia, Samsher Singh, Kiel Hards, Chen-Yi Cheung, Ekaterina Sviriaeva, Amir Banaei-Esfahani, Ruedi Aebersold, Michael Berney, Gregory M. Cook, Kevin Pethe
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112444- (2023)
Summary: The bioenergetic mechanisms by which Mycobacterium tuberculosis survives hypoxia are poorly understood. Current models assume that the bacterium shifts to an alternate electron acceptor or fermentation to maintain membrane potential and ATP
Externí odkaz:
https://doaj.org/article/9d80392a417e4e81ac7c55890f889fb7
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/84f99e0432be453eae633d8eadbb8d10
Autor:
Nicole Scherr, Raphael Bieri, Sangeeta S. Thomas, Aurélie Chauffour, Nitin Pal Kalia, Paul Schneide, Marie-Thérèse Ruf, Araceli Lamelas, Malathy S. S. Manimekalai, Gerhard Grüber, Norihisa Ishii, Koichi Suzuki, Marcel Tanner, Garrett C. Moraski, Marvin J. Miller, Matthias Witschel, Vincent Jarlier, Gerd Pluschke, Kevin Pethe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success. Here, the authors show that a clinical-stage drug candidate for tuberculosis, Q203, is effe
Externí odkaz:
https://doaj.org/article/ead11814b4ee465d85398bdcb2064c81
Publikováno v:
Current Trends in the Identification and Development of Antimicrobial Agents ISBN: 9789815080056
The discovery of penicillin opened the avenues for antibacterial drug discovery to address the global problem of deadly infectious diseases. However, despite the availability of potent antibiotics and effective vaccines, bacterial infections are stil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec54f012e139a5433e4e10bf0a584a78
https://doi.org/10.2174/9789815080056123020007
https://doi.org/10.2174/9789815080056123020007
Autor:
Venkata Madhavi Yaddanapudi, Ojaswitha Ommi, Mohammed Naiyaz Ahmad, Siva Nageswara Rao Gajula, Parita Wanjari, Shashikanta Sahu, Puja Kumari Agnivesh, Santosh Kumar Sahoo, Nitin Pal Kalia, Rajesh Sonti, Srinivas Nanduri, Arunava Dasgupta, Sidharth Chopra
Publikováno v:
RSC Medicinal Chemistry.
The urgent development of newer alternatives has been deemed a panacea for tackling emerging antimicrobial resistance effectively. Herein, we report the design, synthesis, and biological evaluation of 1,3-diaryl substituted pyrazole-based...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaa7868770e34fd93f57388e380a15e9
https://doi.org/10.1039/d3md00079f
https://doi.org/10.1039/d3md00079f
Publikováno v:
Drug Discovery Today. 28:103490
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4207d3730c86cb3142779bf2897140cb
https://doi.org/10.1016/j.drudis.2023.103490
https://doi.org/10.1016/j.drudis.2023.103490
Autor:
Patcharaporn Sae-Lao, Wuan Geok Saw, Chaudhari Namrata Pradeep, Anders Poulsen, Jocelyn Hui Ling Tan, Jickky Palmae Sarathy, Pearly Shuyi Ng, Gerhard Grüber, Peter Dröge, Revathy Kalyanasundaram, Pattarakiat Seankongsuk, Priya Ragunathan, Sivaraj Anbarasu, Umayal Lakshmanan, Harshyaa Makhija, Roderick W. Bates, Kevin Pethe, Krupakar Parthasarathy, Thomas Dick, Amaravadhi Harikishore, Adam Hotra, Joon Shin, Nitin Pal Kalia
Publikováno v:
Angewandte Chemie. 132:13397-13406
The F1 FO -ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clinical target. A mycobacterium-specific loop of the enzyme's rotary γ subunit plays a role in the coupling of ATP synthesis within the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ffd8a157e15476795321ceca37daa1
https://doi.org/10.1002/ange.202002546
https://doi.org/10.1002/ange.202002546
Publikováno v:
Methods in Molecular Biology ISBN: 9781071617786
Generation and characterization of drug resistant mutants is a powerful tool in antimicrobial drug discovery for identification of the molecular target of an investigational drug candidate. The method is relatively simple to be conducted in a classic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::880205e65fdc63b18124ef055523cadb
https://doi.org/10.1007/978-1-0716-1779-3_20
https://doi.org/10.1007/978-1-0716-1779-3_20
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2387
Generation and characterization of drug resistant mutants is a powerful tool in antimicrobial drug discovery for identification of the molecular target of an investigational drug candidate. The method is relatively simple to be conducted in a classic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8fa81719f77f5b2a872e0088a06a85d6
https://pubmed.ncbi.nlm.nih.gov/34643915
https://pubmed.ncbi.nlm.nih.gov/34643915