Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nitin Koul"'
Publikováno v:
Cellular Signalling. 23:1869-1875
The insulin-like growth factor (IGF-1) induces hypoxia inducible factor (HIF-1α) regulated genes in glioblastoma multiforme (GBM). As HIF-1α links inflammatory and oncogenic pathways in GBM, we investigated whether IGF-1 affects HIF-1α to regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1728c8d1b5e64ec824a6defa869cd60b
https://doi.org/10.1016/j.cellsig.2011.06.024
https://doi.org/10.1016/j.cellsig.2011.06.024
Publikováno v:
Journal of Molecular Medicine. 89:123-136
We observed elevated levels of pro-inflammatory cytokine IL-1β in glioblastoma multiforme tumor samples. Since hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in linking inflammatory and oncogenic pathways, we investigated the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a52b2f4dc587180de41fc1ce5ac9b7e8
https://doi.org/10.1007/s00109-010-0683-5
https://doi.org/10.1007/s00109-010-0683-5
Publikováno v:
Free Radical Biology and Medicine. 47:364-374
The poor prognosis of glioblastoma multiforme and lack of effective therapy have necessitated the identification of new treatment strategies. We have previously reported that elevation of oxidative stress induces apoptosis of glioma cells. Because th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8654ac3fc4f0c80a7221d4a8b6eae7f2
https://doi.org/10.1016/j.freeradbiomed.2009.04.031
https://doi.org/10.1016/j.freeradbiomed.2009.04.031
Publikováno v:
Journal of Cellular and Molecular Medicine
The present study identified a novel mechanism of induction of apoptosis in glioblastoma cells by scriptaid – a histone deacetylase (HDAC) inhibitor. Scriptaid reduced glioma cell viability by increasing Jun N-terminal kinase (JNK) activation. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f1b33d88b01e5ae88fa4e8de5e2f33
https://doi.org/10.1111/j.1582-4934.2009.00844.x
https://doi.org/10.1111/j.1582-4934.2009.00844.x
Autor:
Abhishek Ghosh, Vivek Sharma, Richa Tewari, Ugir Hossain Sk, Nitin Koul, Ellora Sen, Christy Joseph
Publikováno v:
Molecular Oncology. 3:77-83
We investigated the pro-inflammatory response mediated by TNFalpha in glioblastoma and whether treatment with organoselenium Ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]one) can affect TNFalpha induced inflammatory response. Exposure to TNFalpha incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b05aa95858a08a5c0c39699412adb4
https://doi.org/10.1016/j.molonc.2008.10.004
https://doi.org/10.1016/j.molonc.2008.10.004
Autor:
Pankaj Seth, Nitin Koul
Publikováno v:
Journal of Biosciences. 33:405-421
Until recently, the neuroscience community held the belief that glial cells such as astrocytes and oligodendrocytes functioned solely as “support” cells of the brain. In this role, glial cells simply provide physical support and housekeeping func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465fc5e387599ac7a7661b2ff10fd2fb
https://doi.org/10.1007/s12038-008-0060-5
https://doi.org/10.1007/s12038-008-0060-5
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 328 (2010)
BMC Cancer
BMC Cancer
Background The highly resistant nature of glioblastoma multiforme (GBM) to chemotherapy prompted us to evaluate the efficacy of bicyclic triterpenoid Iripallidal against GBM in vitro. Methods The effect of Iripallidal on proliferation and apoptosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adf30261dcc30f6e8cf7d7bac567530
https://doi.org/10.1186/1471-2407-10-328
https://doi.org/10.1186/1471-2407-10-328
Publikováno v:
Journal of neurochemistry. 107(3)
The anti-neoplastic property of alkyl phospholipids has been tested for the treatment of several malignancies. In this study, we evaluated the efficacy of miltefosine (Hexadecylphosphocholine--an alkyl phospholipids analogue) on glioblastoma multifor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca26cc051920a079324bcd393526df7
https://pubmed.ncbi.nlm.nih.gov/18710416
https://pubmed.ncbi.nlm.nih.gov/18710416
Publikováno v:
Scopus-Elsevier
Polyphenol epigallocatechin-3-gallate (EGCG) induced apoptosis in glioma cells by elevating oxidative stress through increased reactive oxygen species (ROS) generation. Signs of apoptosis included altered mitochondrial membrane potential and elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8970eb3dd67c0dd97342fd51238d8f
https://doi.org/10.3892/mmr.1.4.511
https://doi.org/10.3892/mmr.1.4.511
Publikováno v:
Cancer Research. 69:A50-A50
Purpose: We observed elevated levels of the pro-inflammatory cytokine IL-1β in glioblastoma multiforme (GBM) tumor samples. Since Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in linking inflammatory and oncogenic pathways, we investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a068d4fbdcde62370cec42fa64087c02
https://doi.org/10.1158/0008-5472.fbcr09-a50
https://doi.org/10.1158/0008-5472.fbcr09-a50