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Autor:
Neill R. Graff-Radford, Jelena Mojsilovic-Petrovic, Fadia Ibrahim, Zamia Diaz, Kelly L. Williams, Garth A. Nicholson, Ashley Chiang, John Q. Trojanowski, Lauren Elman, Nancy M. Bonini, Oliver D. King, Dennis W. Dickson, James Epstein, Rosa Rademakers, Hyung-Jun Kim, Robert G. Kalb, Rachel Oristano, Dana Clay-Falcone, Jennifer A. Solski, Tadashi Nakaya, Leo McCluskey, Ian P. Blair, Divya Hosangadi, Caroline Ingre, Michael P. Hart, Albert C. Ludolph, Zissimos Mourelatos, Robert W. Greene, Annie X. Liu, Virginia M.-Y. Lee, Aaron D. Gitler, Daniel M. Ramos, Julien Couthouis, Renske Erion, Kevin B. Boylan, Niti Jethava, Mariely DeJesus-Hernandez, Peter M. Andersen, James Shorter, Wim Robberecht, Vivianna M. Van Deerlin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Amyotrophic lateral sclerosis (ALS) is a devastating and universally fatal neurodegenerative disease. Mutations in two related RNA-binding proteins, TDP-43 and FUS, that harbor prion-like domains, cause some forms of ALS. There are at least 213 human