Asciminib monotherapy in patients with CML-CP without BCR::ABL1 T315I mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results

Autor: Michael J. Mauro, Timothy P. Hughes, Dong-Wook Kim, Delphine Rea, Jorge E. Cortes, Andreas Hochhaus, Koji Sasaki, Massimo Breccia, Moshe Talpaz, Oliver Ottmann, Hironobu Minami, Yeow Tee Goh, Daniel J. DeAngelo, Michael C. Heinrich, Valle Gómez-García de Soria, Philipp le Coutre, Francois-Xavier Mahon, Jeroen J. W. M. Janssen, Michael Deininger, Naranie Shanmuganathan, Mark B. Geyer, Silvia Cacciatore, Fotis Polydoros, Nithya Agrawal, Matthias Hoch, Fabian Lang

Publikováno v: Mauro, M J, Hughes, T P, Kim, D-W, Rea, D, Cortes, J E, Hochhaus, A, Sasaki, K, Breccia, M, Talpaz, M, Ottmann, O, Minami, H, Goh, Y T, DeAngelo, D J, Heinrich, M C, Gómez-García de Soria, V, le Coutre, P, Mahon, F-X, Janssen, J J W M, Deininger, M, Shanmuganathan, N, Geyer, M B, Cacciatore, S, Polydoros, F, Agrawal, N, Hoch, M & Lang, F 2023, ' Asciminib monotherapy in patients with CML-CP without BCR : :ABL1 T315I mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results ', Leukemia, vol. 37, no. 5, pp. 1048-1059 . https://doi.org/10.1038/s41375-023-01860-w
Leukemia, 37(5), 1048-1059. Nature Publishing Group

Asciminib is approved for patients with Philadelphia chromosome–positive chronic-phase chronic myeloid leukemia (CML-CP) who received ≥2 prior tyrosine kinase inhibitors or have the T315I mutation. We report updated results of a phase 1, open-lab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437d3c00079171293194868f1b37fa7b
https://research.vumc.nl/en/publications/6d526334-4128-4e79-a87b-30d3fb304c73

Poster: CML-466 Asciminib Provides Durable Molecular Responses in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With the T315I Mutation: Updated Efficacy and Safety Data From a Phase I Trial

Autor: Timothy P. Hughes, Jorge E. Cortes, Delphine Réa, Michael J. Mauro, Andreas Hochhaus, Dong-Wook Kim, Koji Sasaki, Fabian Lang, Michael C. Heinrich, Massimo Breccia, Michael Deininger, Yeow-Tee Goh, Jeroen J.W.M Janssen, Moshe Talpaz, Philipp le Coutre, Shruti Kapoor, Silvia Cacciatore, Fotis Polydoros, Nithya Agrawal, Francois-Xavier Mahon

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 22:S146

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05215951f14c123e7febaeb253961968
https://doi.org/10.1016/s2152-2650(22)00882-5