Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nitesh Kumar Khandelwal"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Yeast Cadmium Factor 1 (Ycf1) sequesters glutathione and glutathione-heavy metal conjugates into yeast vacuoles as a cellular detoxification mechanism. Ycf1 belongs to the C subfamily of ATP Binding Cassette (ABC) transporters characterized
Externí odkaz:
https://doaj.org/article/6821288c06054450bec9a5b11d854742
Autor:
Nitesh Kumar Khandelwal, Cinthia R. Millan, Samantha I. Zangari, Samantha Avila, Dewight Williams, Tarjani M. Thaker, Thomas M. Tomasiak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Ycf1, a C-family member ATP Binding Cassette (ABC) transporter, transports glutathione and glutathione-metal complexes in yeast. Here the authors use cryo-EM and biochemical analysis to show how an intrinsically-disordered regulatory domain (R-domain
Externí odkaz:
https://doaj.org/article/1b1ddd945c58459bbc161a3c5f0f4886
Autor:
Sonam Kumari, Mohit Kumar, Brooke D. Esquivel, Mohd Wasi, Ajay Kumar Pandey, Nitesh Kumar Khandelwal, Alok K. Mondal, Theodore C. White, Rajendra Prasad, Naseem A. Gaur
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT In this study, 18 predicted membrane-localized ABC transporters of Candida glabrata were deleted individually to create a minilibrary of knockouts (KO). The transporter KOs were analyzed for their susceptibility toward antimycotic drugs. Alt
Externí odkaz:
https://doaj.org/article/f10bed7c48c4410ea6c6ada83ec2dc52
Autor:
Garima Shahi, Mohit Kumar, Nitesh Kumar Khandelwal, Atanu Banerjee, Parijat Sarkar, Sonam Kumari, Brooke D. Esquivel, Neeraj Chauhan, Amitabha Chattopadhyay, Theodore C. White, Naseem A. Gaur, Ashutosh Singh, Rajendra Prasad
Publikováno v:
Journal of Fungi, Vol 8, Iss 7, p 651 (2022)
In this study, we have specifically blocked a key step of sphingolipid (SL) biosynthesis in Candida glabrata by disruption of the orthologs of ScIpt1 and ScSkn1. Based on their close homology with S. cerevisiae counterparts, the proteins are predicte
Externí odkaz:
https://doaj.org/article/042d099b74d3401890bb9f48bc56b6e7
Autor:
Mohd Wasi, Nitesh Kumar Khandelwal, Alexander J. Moorhouse, Remya Nair, Poonam Vishwakarma, Gustavo Bravo Ruiz, Zoe K. Ross, Alexander Lorenz, Shivaprakash M. Rudramurthy, Arunaloke Chakrabarti, Andrew M. Lynn, Alok K. Mondal, Neil A. R. Gow, Rajendra Prasad
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
ATP-binding cassette (ABC) superfamily members have a key role as nutrient importers and exporters in bacteria. However, their role as drug exporters in eukaryotes brought this superfamily member to even greater prominence. The capacity of ABC transp
Externí odkaz:
https://doaj.org/article/3c8c88fc2ef04f649c4f31dc3da61b1c
Autor:
Sonam Kumari, Mohit Kumar, Nitesh Kumar Khandelwal, Priya Kumari, Mahendra Varma, Poonam Vishwakarma, Garima Shahi, Suman Sharma, Andrew M Lynn, Rajendra Prasad, Naseem A Gaur
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202993 (2018)
ATP-binding cassette (ABC) is one of the two major superfamilies of transporters present across the evolutionary scale. ABC superfamily members came to prominence due to their ability to extrude broad spectrum of substrates and to confer multi drug r
Externí odkaz:
https://doaj.org/article/ad732fe984bf42029de54364917c6ba2
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Fungal pathogens have a robust array of multidrug transporters which aid in active expulsion of drugs and xenobiotics to help them evade toxic effects of drugs. Thus, these transporters impose a major impediment to effective chemotherapy. Although th
Externí odkaz:
https://doaj.org/article/7b5297eb04b2488a810af1afe28a047c
Autor:
Kaushal Kumar Mahto, Ashutosh Singh, Nitesh Kumar Khandelwal, Nitin Bhardwaj, Jaykar Jha, Rajendra Prasad
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113664 (2014)
A critical question among the researchers working on fungal lipid biology is whether the use of an enriched growth medium can affect the lipid composition of a cell and, therefore, contribute to the observed phenotypes. One presumption is that enrich
Externí odkaz:
https://doaj.org/article/5579e9b8eb144e87b572a8d89a242f08
Autor:
Sanjiveeni Dhamgaye, Frédéric Devaux, Patrick Vandeputte, Nitesh Kumar Khandelwal, Dominique Sanglard, Gauranga Mukhopadhyay, Rajendra Prasad
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104554 (2014)
Candida albicans causes superficial to systemic infections in immuno-compromised individuals. The concomitant use of fungistatic drugs and the lack of cidal drugs frequently result in strains that could withstand commonly used antifungals, and displa
Externí odkaz:
https://doaj.org/article/156fddb79b5a48a49cda1c47ccbb782b
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2517
The recently emerged human pathogenic yeast Candida auris has become a major global threat. As compared to other Candida species, C. auris often displays a high level of resistance to commonly used antifungals and poses additional therapeutic challen