Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.

Autor: Chaitali Misra, Nita Sachan, Caryn Rothrock McNally, Sara N Koenig, Haley A Nichols, Anuradha Guggilam, Pamela A Lucchesi, William T Pu, Deepak Srivastava, Vidu Garg

Publikováno v: PLoS Genetics, Vol 8, Iss 5, p e1002690 (2012)

Defects of atrial and ventricular septation are the most frequent form of congenital heart disease, accounting for almost 50% of all cases. We previously reported that a heterozygous G296S missense mutation of GATA4 caused atrial and ventricular sept

Externí odkaz: https://doaj.org/article/8e619ecf80d14f26a44be5766806ce46

Wound-induced gene expression of putrescine N-methyltransferase in leaves of Nicotiana tabacum

Autor: Nita Sachan, Deane L. Falcone

Publikováno v: Phytochemistry. 61:797-805

Putrescine N-methyltransferase (PMT) catalyzes the first committed step in the biosynthesis of pyrrolinium ring-containing alkaloids. Earlier studies have indicated that PMT gene expression is restricted to root tissue in Solanaceus plant species. Du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea944c12b075e08b184a432805a1827d
https://doi.org/10.1016/s0031-9422(02)00427-2

Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo

Autor: Sara N. Koenig, William T. Pu, Vidu Garg, Chaitali Misra, Caryn Rothrock McNally, Pamela A. Lucchesi, Nita Sachan, Deepak Srivastava, Haley A. Nichols, Anuradha Guggilam

Publikováno v: Misra, C; Sachan, N; McNally, CR; Koenig, SN; Nichols, HA; Guggilam, A; et al.(2012). Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genetics, 8(5). doi: 10.1371/journal.pgen.1002690. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2hw8b3rx
PLoS genetics, vol 8, iss 5
PLoS Genetics, Vol 8, Iss 5, p e1002690 (2012)
PLoS Genetics

Defects of atrial and ventricular septation are the most frequent form of congenital heart disease, accounting for almost 50% of all cases. We previously reported that a heterozygous G296S missense mutation of GATA4 caused atrial and ventricular sept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a55935dbfd1491aa2f545302fad73bb
http://www.escholarship.org/uc/item/2hw8b3rx

Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart

Autor: James A. Bibb, David Rotter, John M. Shelton, Beverly A. Rothermel, Misook Oh, Joseph A. Hill, Victoria Copeland, Devanjan Sikder, Pavan K. Battiprolu, Erik Bush, D. Bennett Grinsfelder, Nita Sachan, Asim Dey

Publikováno v: Circulation research. 108(4)

Rationale: Despite overwhelming evidence of the importance of circadian rhythms in cardiovascular health and disease, little is known regarding the circadian regulation of intracellular signaling pathways controlling cardiac function and remodeling.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df36270b51092c612282b7f1bb33b13
https://pubmed.ncbi.nlm.nih.gov/21233454

FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases

Autor: Joseph A. Hill, Na Wang, Nita Sachan, Makoto Kuro-o, Dian J. Cao, Beverly A. Rothermel, Robert D. Gerard, David J. Morris, Yan G. Ni

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 104(51)

Insulin resistance and metabolic syndrome are rapidly expanding public health problems. Acting through the PI3K/Akt pathway, insulin and insulin-like growth factor-1 (IGF-1) inactivate FoxO transcription factors, a class of highly conserved proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad11182ca67d41dd536014409e915ce1
https://pubmed.ncbi.nlm.nih.gov/18077353