Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nita J. Patel"'
Autor:
Nita J Patel, Enaksha Wickremsinhe, Yu-Hua Hui, Alexandar Barr, Nicholas Masterson, Kenneth Ruterbories, Jennifer Weller, Jennifer Hanes, Tom Kern, Everett Perkins
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 19, Iss 4 (2016)
Purpose: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles. The purpose of this work was to evaluate and optimize blood micros
Externí odkaz:
https://doaj.org/article/db21fa830dc445b49911f3b6363578ad
Autor:
Kristy Kikly, Howard Barff Broughton, William Chang, Selma Sapmaz, Richard Morphy, Holly A. Bina, Jim D. Durbin, Sherry Y Guo, Timothy Ivo Richardson, Jimmy P Steele, Ryan Edward Stites, Brian G. Getman, Vaught Grant Matthews, Veavi Ching-Yun Chang, Pamela K. Shetler, Greg L Durst, Denise D Edmondson, Rob Barr, Helene Rudyk, Charles Willis Lugar, Nita J. Patel, Christian Alexander Clarke, Kelly Wayne Furness, Nicole E New, David K. Clawson, Keith R. Stayrook, Mark Chambers, Brian Michael Mathes, Stephanie L. Stout, Wendy H. Gough
Publikováno v:
Journal of Medicinal Chemistry. 64:5470-5484
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Autor:
David T. White, Naijia Huang, Jeffrey S. Tan, Kenneth J. Ruterbories, Jason Liu, Derek Brocksmith, Lee J. Burns, Alain Stricker-Krongrad, Nathan Yumibe, Nita J. Patel, Guy Bouchard
Publikováno v:
International Journal of Pharmacokinetics. 2:81-91
Aim: Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the P
Autor:
Kostas Gavardinas, John G. Luz, Nathan A. Calvert, Vaught Grant Matthews, Pablo Garcia Losada, Heather A Bullock, Ashraf Saeed, Donald P. Matthews, Yong Wang, Nita J. Patel, Venkatesh Krishnan, Judith W. Henck, Jonathan Edward Green, Sweetana Stephanie Ann, Prabhakar Kondaji Jadhav
Publikováno v:
Journal of Medicinal Chemistry. 59:750-755
A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) and liver-mediated decrease in HDL-C. 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)
Publikováno v:
Pharmaceutical Research. 35
One of the authors has his name incorrectly indexed in PubMed and SpringerLink as “Laird Forrest M” (last name “Laird Forrest”). His name should index as “Forrest M. Laird” with last name as “Forrest”.
Publikováno v:
Pharmaceutical Research. 35
PURPOSE: To investigate influence of inflammation on metabolism and pharmacokinetics (PK) of midazolam (MDZ) and construct a semi-physiologically based pharmacokinetic (PBPK) model to predict PK in mice with inflammatory disease. METHODS: Glucose-6-p
Autor:
Everett J. Perkins, Nicholas Masterson, Alexandar Barr, Nita J. Patel, Tom G. Kern, Jennifer M. Weller, Jennifer L Hanes, Yu-hua Hui, Enaksha R Wickremsinhe, Kenneth J. Ruterbories
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 19, Iss 4 (2016)
Purpose: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles. The purpose of this work was to evaluate and optimize blood micros
Publikováno v:
Journal of Pharmaceutical Sciences. 102:2859-2874
Identifying the source of inter- and/or intrasubject variability in pharmacokinetics (PK) provides fundamental information in understanding the pharmacokinetics-pharmacodynamics relationship of a drug and project its efficacy and safety in clinical p
Autor:
Jessica Rehmel, Ping Yi, Jason T. Johnson, Chad E. Hadden, Kristina M. Campanale, Nita J. Patel, Kenneth C. Cassidy
Publikováno v:
Drug Metabolism and Disposition. 40:2354-2364
The disposition and metabolism of isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate (LY2452473; a selective androgen receptor modulator) in humans was characterized after a single 15-mg (100 μCi) oral dos
Autor:
Timothy Ivo Richardson, Chahrzad Montrose-Rafizadeh, Scott Alan Jones, Terry L. Moore, Thomas J. Bleisch, John J. Osborne, Charles Willis Lugar, Yu Kuo-Long, Jeffrey Alan Dodge, Pamela K. Shetler, Nita J. Patel, Christian Alexander Clarke, Andrew G. Geiser, Jose Eduardo Lopez, Rachelle J. Sells Galvin, Brian Stephen Muehl, Ying K. Yee, Norman Earle Hughes, Richard W. Zink
Publikováno v:
ACS Medicinal Chemistry Letters. 2:148-153
We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. These compounds demonstrated excellent selectivity over other