Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Nissim Hay"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Metabolic rewiring during the proliferation-to-quiescence transition is poorly understood. Here, using a model of contact inhibition-induced quiescence, we conducted 13C-metabolic flux analysis in proliferating (P) and quiescent (Q) mouse em
Externí odkaz:
https://doaj.org/article/27d4f9ef5fda478ca28215773e9b8a91
Autor:
Mitsugu Shimobayashi, Amandine Thomas, Sunil Shetty, Irina C Frei, Bettina K Wölnerhanssen, Diana Weissenberger, Anke Vandekeere, Mélanie Planque, Nikolaus Dietz, Danilo Ritz, Anne Christin Meyer-Gerspach, Timm Maier, Nissim Hay, Ralph Peterli, Sarah-Maria Fendt, Nicolas Rohner, Michael N Hall
Publikováno v:
eLife, Vol 12 (2023)
Chronically high blood glucose (hyperglycemia) leads to diabetes and fatty liver disease. Obesity is a major risk factor for hyperglycemia, but the underlying mechanism is unknown. Here, we show that a high-fat diet (HFD) in mice causes early loss of
Externí odkaz:
https://doaj.org/article/c1e2768af6504e0cbd38f53c60cca042
Autor:
Catherine S. Blaha, Gopalakrishnan Ramakrishnan, Sang-Min Jeon, Veronique Nogueira, Hyunsoo Rho, Soeun Kang, Prashanth Bhaskar, Alexander R. Terry, Alexandre F. Aissa, Maxim V. Frolov, Krushna C. Patra, R. Brooks Robey, Nissim Hay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Hexokinase 2 expression is markedly induced in cancer cells and contributes to cancer cell metabolism. Here, the authors show that hexokinase 2 can contribute to the metastatic spread of cancer cells independently of its glycolytic function via inhib
Externí odkaz:
https://doaj.org/article/78bfbaa457e843ebaad6087dacfee23a
Autor:
Milad J Alasady, Alexander R Terry, Adam D Pierce, Michael C Cavalier, Catherine S Blaha, Kaylin A Adipietro, Paul T Wilder, David J Weber, Nissim Hay
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256238 (2021)
S100B is frequently elevated in malignant melanoma. A regulatory mechanism was uncovered here in which elevated S100B lowers mRNA and secreted protein levels of interleukin-6 (IL6) and inhibits an autocrine loop whereby IL6 activates STAT3 signaling.
Externí odkaz:
https://doaj.org/article/9e8cdda96b274951af8b33b4ddfe5607
Autor:
Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay, Navdeep S. Chandel
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-18 (2018)
Abstract Background T cells and cancer cells utilize glycolysis for proliferation. The hexokinase (1–4) family of enzymes catalyze the first step of glycolysis. Hexokinase 2 (HK2) is one of the most highly upregulated metabolic enzymes in both canc
Externí odkaz:
https://doaj.org/article/84278dafdee54bb999a4ec239b5afd5a
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2629-2642 (2018)
Aerobic glycolysis accounts for ∼80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear. Here, we further established the role of aerobic glycolysis in murine r
Externí odkaz:
https://doaj.org/article/916cd834449f41b29b5ee5f1be4232ab
Autor:
Dannielle DeWaal, Veronique Nogueira, Alexander R. Terry, Krushna C. Patra, Sang-Min Jeon, Grace Guzman, Jennifer Au, Christopher P. Long, Maciek R. Antoniewicz, Nissim Hay
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Hexokinase 2 (HK2) is selectively upregulated in hepatocellular carcinoma (HCC). Here the authors show that HK2 ablation decreases glycolysis and triggers oxidative phosphorylation (OXPHO) rendering HCC more susceptible to the OXPHO inhibitor metform
Externí odkaz:
https://doaj.org/article/b4eb4726703e40cea6442db1aeb36e9f
Autor:
Sang-Min Jeon, Nissim Hay
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 4, Pp 1-3 (2018)
Externí odkaz:
https://doaj.org/article/f986666edeb1440ab63ed1576a51235c
Autor:
Bethany A. Kerr, Xiaoxia Z. West, Young-Woong Kim, Yongzhong Zhao, Miroslava Tischenko, Rebecca M. Cull, Timothy W. Phares, Xiao-Ding Peng, Jeremiah Bernier-Latmani, Tatiana V. Petrova, Ralf H. Adams, Nissim Hay, Sathyamangla V. Naga Prasad, Tatiana V. Byzova
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dys
Externí odkaz:
https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af6
Publikováno v:
eLife, Vol 7 (2018)
Akt activation in human cancers exerts chemoresistance, but pan-Akt inhibition elicits adverse consequences. We exploited the consequences of Akt-mediated mitochondrial and glucose metabolism to selectively eradicate and evade chemoresistance of pros
Externí odkaz:
https://doaj.org/article/6d4103e6d02a47d7be5bbd23795abd41