New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project

Autor: Ramhøj, Louise, Axelstad, Marta, Baert, Yoni, Cañas-Portilla, Ana I, Chalmel, Frédéric, Dahmen, Lars, De La Vieja, Antonio, Evrard, Bertrand, Haigis, Ann-Cathrin, Hamers, Timo, Heikamp, Kim, Holbech, Henrik, Iglesias-Hernandez, Patricia, Knapen, Dries, Marchandise, Lorna, Morthorst, Jane E, Nikolov, Nikolai Georgiev, Nissen, Ana C V E, Oelgeschlaeger, Michael, Renko, Kostja, Rogiers, Vera, Schüürmann, Gerrit, Stinckens, Evelyn, Stub, Mette H, Torres-Ruiz, Monica, Van Duursen, Majorie, Vanhaecke, Tamara, Vergauwen, Lucia, Wedebye, Eva Bay, Svingen, Terje

Publikováno v: Frontiers in Toxicology
Frontiers in Toxicology, 2023, 5, pp.1189303. ⟨10.3389/ftox.2023.1189303⟩
Frontiers in toxicology
Ramhøj, L, Axelstad, M, Baert, Y, Cañas-Portilla, A I, Chalmel, F, Dahmen, L, De La Vieja, A, Evrard, B, Haigis, A-C, Hamers, T, Heikamp, K, Holbech, H, Iglesias-Hernandez, P, Knapen, D, Marchandise, L, Morthorst, J E, Nikolov, N G, Nissen, A C V E, Oelgeschlaeger, M, Renko, K, Rogiers, V, Schüürmann, G, Stinckens, E, Stub, M H, Torres-Ruiz, M, Van Duursen, M, Vanhaecke, T, Vergauwen, L, Wedebye, E B & Svingen, T 2023, ' New approach methods to improve human health risk assessment of thyroid hormone system disruption-a PARC project ', Frontiers in Toxicology, vol. 5, 1189303 . https://doi.org/10.3389/ftox.2023.1189303

Current test strategies to identify thyroid hormone (TH) system disruptors are inadequate for conducting robust chemical risk assessment required for regulation. The tests rely heavily on histopathological changes in rodent thyroid glands or measurin

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https://doi.org/10.3389/ftox.2023.1189303