Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.

Autor: Pantsar T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland. Electronic address: tatu.pantsar@uef.fi., Singha P; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern 5 Finland, 70211 Kuopio, Finland., Nevalainen TJ; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland., Koshevoy I; Department of Chemistry, University of Eastern Finland, P.O. Box 111, FIN-80101 Joensuu, Finland., Leppänen J; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland., Poso A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland; Department of Internal Medicine VIII, University Hospital Tuebingen, 72076 Tuebingen, Germany., Niskanen JMA; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern 5 Finland, 70211 Kuopio, Finland., Pasonen-Seppänen S; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern 5 Finland, 70211 Kuopio, Finland., Savinainen JR; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern 5 Finland, 70211 Kuopio, Finland., Laitinen T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland., Laitinen JT; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern 5 Finland, 70211 Kuopio, Finland.

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2017 Sep 30; Vol. 107, pp. 97-111. Date of Electronic Publication: 2017 Jul 05.