Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nisintha Mahendrarajah"'
Autor:
Miriam Pons, Yanira Zeyn, Stella Zahn, Nisintha Mahendrarajah, Brent D. G. Page, Patrick T. Gunning, Richard Moriggl, Walburgis Brenner, Falk Butter, Oliver H. Krämer
Publikováno v:
Cancers, Vol 13, Iss 14, p 3464 (2021)
The ribonucleotide reductase inhibitor hydroxyurea suppresses de novo dNTP synthesis and attenuates the hyperproliferation of leukemic blasts. Mechanisms that determine whether cells undergo apoptosis in response to hydroxyurea are ill-defined. We us
Externí odkaz:
https://doaj.org/article/fb7d0bb0a27d40dca6ec34bb309cb40a
Autor:
Miriam, Pons, Yanira, Zeyn, Stella, Zahn, Nisintha, Mahendrarajah, Brent D G, Page, Patrick T, Gunning, Richard, Moriggl, Walburgis, Brenner, Falk, Butter, Oliver H, Krämer
Publikováno v:
Cancers, Vol 13, Iss 3464, p 3464 (2021)
Cancers
Volume 13
Issue 14
Cancers
Volume 13
Issue 14
Simple Summary Leukemic cells show differential sensitivity to apoptosis induction by the clinically relevant drug hydroxyurea. Since resistance to hydroxyurea can pose a therapeutic problem, we searched for mechanisms that protect such cells from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb92f89167806dab887297e5dbe08cc
Autor:
Nisintha Mahendrarajah, Oliver H. Krämer, Christian Wichmann, Nicole Kiweler, Christoph Englert, Claudia M Reichardt, Dorle Hennig, Carol Stocking, Miriam Pons, Thorsten Heinzel, Sigrid Reichardt, Abinaya Nathan, Jörg Hartkamp, Günter Schneider, Markus Christmann, Falk Butter
Publikováno v:
Pons, M, Reichardt, C M, Hennig, D, Nathan, A, Kiweler, N, Stocking, C, Wichmann, C, Christmann, M, Butter, F, Reichardt, S, Schneider, G, Heinzel, T, Englert, C, Hartkamp, J, Krämer, O H & Mahendrarajah, N 2018, ' Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells ', Archives of Toxicology, vol. 92, no. 6, pp. 2119-2135 . https://doi.org/10.1007/s00204-018-2202-3
A remaining expression of the transcription factor Wilms tumor 1 (WT1) after cytotoxic chemotherapy indicates remaining leukemic clones in patients. We determined the regulation and relevance of WT1 in leukemic cells exposed to replicative stress and
Autor:
Anja Göder, Claudia Schäfer, Jürgen Sonnemann, Nisintha Mahendrarajah, Thorsten Heinzel, Natasa Stojanovic, Andreas Sellmer, Oliver H. Krämer, Sascha Dietrich, Martin Wieczorek, Teodora Nikolova, Maja T. Tomicic, Siavosh Mahboobi, Mandy Beyer, Günter Schneider, Anke Rauch, Thomas R. Reich, Michael Linnebacher, Nicole Kiweler
Publikováno v:
Cellular Signalling. 29:218-225
The transcription factors NF-κB and p53 as well as their crosstalk determine the fate of tumor cells upon therapeutic interventions. Replicative stress and cytokines promote signaling cascades that lead to the co-regulation of p53 and NF-κB. Conseq
Autor:
Oliver H. Krämer, Nisintha Mahendrarajah, Katharina Schmid, Andreas Sellmer, Marina E. Borisova, Sigrid Reichardt, Thorsten Heinzel, Andrea Haitel, Petra Beli, Siavosh Mahboobi, Lukas Kenner, Maren Godmann
Publikováno v:
Cellular signalling. 39
Signal transducers and activators of transcription (STATs) are latent, cytoplasmic transcription factors. Janus kinases (JAKs) and activated CDC42-associated kinase-1 (ACK1/TNK2) catalyse the phosphorylation of STAT1 and the expression of its target
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1510
Autophagy is a lysosome-dependent, intracellular pathway for the recycling of cellular components. It plays a pivotal role in both cancer development and the response to chemotherapy. Here we describe how autophagy can be monitored in living cells by
Publikováno v:
Methods in Molecular Biology ISBN: 9781493965250
Autophagy is a lysosome-dependent, intracellular pathway for the recycling of cellular components. It plays a pivotal role in both cancer development and the response to chemotherapy. Here we describe how autophagy can be monitored in living cells by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2152b7d1d57f8ef695d1f3aa3cc1a0e1
https://doi.org/10.1007/978-1-4939-6527-4_1
https://doi.org/10.1007/978-1-4939-6527-4_1
Publikováno v:
Journal of cancer research and clinical oncology. 142(11)
Activated CDC42-associated kinase-1 (ACK1/TNK2) and epigenetic regulators of the histone deacetylase (HDAC) family regulate the proliferation and survival of leukemic cells. 18 HDACs fall into four classes (I–IV). We tested the impact of clinically
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. An increasing body of evidence suggests that the E3 ubiquitin ligases SIAH1 and SIAH2 are able to dictate the growth, development, and chemo-/radios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d87c7da86f00ed1bdf4f4bda9d5f6a
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=84938294159
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=84938294159
Autor:
Dagmar Hildebrand, Katharina F. Kubatzky, Bernd Kaina, Markus Christmann, Nisintha Mahendrarajah, Oliver H. Krämer, Siavosh Mahboobi, Florian Grebien, Katrin Noack, Dorle Hennig, Thorsten Heinzel, Luisa Schmidt, Andreas Sellmer
Publikováno v:
Archives of Toxicology
Noack, K, Mahendrarajah, N, Hennig, D, Schmidt, L, Grebien, F, Hildebrand, D, Christmann, M, Kaina, B, Sellmer, A, Mahboobi, S, Kubatzky, K, Heinzel, T & Krämer, O H 2017, ' Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells ', Archives of Toxicology, vol. 91, no. 5, pp. 2191-2208 . https://doi.org/10.1007/s00204-016-1878-5
Noack, K, Mahendrarajah, N, Hennig, D, Schmidt, L, Grebien, F, Hildebrand, D, Christmann, M, Kaina, B, Sellmer, A, Mahboobi, S, Kubatzky, K, Heinzel, T & Krämer, O H 2017, ' Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells ', Archives of Toxicology, vol. 91, no. 5, pp. 2191-2208 . https://doi.org/10.1007/s00204-016-1878-5
The treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) induces granulocytic differentiation. This process renders APL cells resistant to cytotoxic chemotherapies. Epigenetic regulators of the histone deacetylases (HDA