Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Nisharnthi M Duggan"'
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming
Autor:
Daniel J Ford, Henri M. H. Spronk, Wenyu Liu, Vishnu M. Sasi, Colin J. Jackson, Tilman M. Hackeng, Nisharnthi M Duggan, Pedro Pereira, Hiroaki Suga, Stijn M. Agten, Anneliese S. Ashhurst, Rene van Oerle, Jorge Ripoll-Rozada, Richard J. Payne, Joe A. Kaczmarski, Leo Corcilius, Toby Passioura, Sarah E. Fry
Publikováno v:
Journal of Medicinal Chemistry, 64(11), 7853-7876. American Chemical Society
The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. Inhibition of Factor XIIa (FXIIa), an initiator
Autor:
David W. Lupton, Martin Breugst, Yuji Nakano, Lydia Scott, Nisharnthi M. Duggan, Xuan B. Nguyen
Publikováno v:
Angewandte Chemie International Edition. 58:11483-11490
Direct polarity inversion of conjugate acceptors provides a valuable entry to homoenolates. N-heterocyclic carbene (NHC) catalyzed reactions, in which β-unsubstituted conjugate acceptors undergo homoenolate formation and C-C bond formation twice, ha