Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nisharnthi M Duggan"'
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming
Autor:
Daniel J Ford, Henri M. H. Spronk, Wenyu Liu, Vishnu M. Sasi, Colin J. Jackson, Tilman M. Hackeng, Nisharnthi M Duggan, Pedro Pereira, Hiroaki Suga, Stijn M. Agten, Anneliese S. Ashhurst, Rene van Oerle, Jorge Ripoll-Rozada, Richard J. Payne, Joe A. Kaczmarski, Leo Corcilius, Toby Passioura, Sarah E. Fry
Publikováno v:
Journal of Medicinal Chemistry, 64(11), 7853-7876. American Chemical Society
The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. Inhibition of Factor XIIa (FXIIa), an initiator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0a2fcd6f50b94b3bfc83aa64363fc4
https://doi.org/10.1021/acs.jmedchem.1c00651
https://doi.org/10.1021/acs.jmedchem.1c00651
Autor:
David W. Lupton, Martin Breugst, Yuji Nakano, Lydia Scott, Nisharnthi M. Duggan, Xuan B. Nguyen
Publikováno v:
Angewandte Chemie International Edition. 58:11483-11490
Direct polarity inversion of conjugate acceptors provides a valuable entry to homoenolates. N-heterocyclic carbene (NHC) catalyzed reactions, in which β-unsubstituted conjugate acceptors undergo homoenolate formation and C-C bond formation twice, ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e8e0aeefff25faf2ea17dc4c8d0e6e
https://doi.org/10.1002/anie.201905475
https://doi.org/10.1002/anie.201905475
Autor:
Nguyen, Xuan B.1 (AUTHOR), Nakano, Yuji1 (AUTHOR), Duggan, Nisharnthi M.1 (AUTHOR), Scott, Lydia1 (AUTHOR), Breugst, Martin2 (AUTHOR), Lupton, David W.1 (AUTHOR) david.lupton@monash.edu
Publikováno v:
Angewandte Chemie. 8/12/2019, Vol. 131 Issue 33, p11607-11614. 8p.