Výsledky vyhledávání - "Nishanth E. Sunny"

Akademický článek

Long-chain fatty acids mediate hepatic metabolic flux in preruminating dairy calves fed flaxseed oil, high oleic soybean oil, or milk fat

Autor: Linda M. Beckett, Victor M.R. Malacco, Kyrstin M. Gouveia, Adrianna Mann, Chaylen J. Andolino, KaLynn Harlow, Nishanth E. Sunny, Rafael C. Neves, John R. Burgess, Jaquelyn P. Boerman, Theresa.M. Casey, Shawn S. Donkin

Publikováno v: Journal of Dairy Science, Vol 107, Iss 10, Pp 7932-7950 (2024)

ABSTRACT: Nutrition and physiological state affect hepatic metabolism. Our objective was to determine whether feeding flaxseed oil (∼50% C18:3n-3 cis), high oleic soybean oil (∼70% C18:1 cis-9), or milk fat (∼50% C16:0) alters hepatic expressio

Externí odkaz: https://doaj.org/article/f6f829d891504842b5fe24c0f3af1d36

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Akademický článek

Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD

Autor: Marc McLeod, Mario C. Chang, Anna Rushin, Mukundan Ragavan, Rohit Mahar, Gaurav Sharma, Arshee Badar, Anthony Giacalone, Max E. Glanz, Vinay R. Malut, Dalton Graham, Nishanth E. Sunny, James A. Bankson, Kenneth Cusi, Matthew E. Merritt

Publikováno v: Cell Reports Medicine, Vol 5, Iss 9, Pp 101714- (2024)

Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe

Externí odkaz: https://doaj.org/article/c5f37c219a1342b59cc8a63717b98100

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Akademický článek

Non-Alcoholic Fatty Liver Disease Induced by Feeding Medium-Chain Fatty Acids Upregulates Cholesterol and Lipid Homeostatic Genes in Skeletal Muscle of Neonatal Pigs

Autor: Samuel D. Gerrard, Fernando H. Biase, Joseph A. Yonke, Ravi Yadav, Anthony J. Shafron, Nishanth E. Sunny, David E. Gerrard, Samer W. El-Kadi

Publikováno v: Metabolites, Vol 14, Iss 7, p 384 (2024)

Non-alcoholic fatty liver disease (NAFLD) is a range of disorders characterized by lipid accumulation in hepatocytes. Although this spectrum of disorders is associated with adult obesity, recent evidence suggests that this condition could also occur

Externí odkaz: https://doaj.org/article/98e9e199f55d4f209e3678c5ab6bde47

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Akademický článek

Remodeling of Hepatocyte Mitochondrial Metabolism and De Novo Lipogenesis During the Embryonic-to-Neonatal Transition in Chickens

Autor: Chaitra Surugihalli, Linda S. Farley, Ronique C. Beckford, Boonyarit Kamkrathok, Hsiao-Ching Liu, Vaishna Muralidaran, Kruti Patel, Tom E. Porter, Nishanth E. Sunny

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Embryonic-to-neonatal development in chicken is characterized by high rates of lipid oxidation in the late-term embryonic liver and high rates of de novo lipogenesis in the neonatal liver. This rapid remodeling of hepatic mitochondrial and cytoplasmi

Externí odkaz: https://doaj.org/article/4e3d1b26238e4805aec3d10210af60a6

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Akademický článek

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insul

Externí odkaz: https://doaj.org/article/27c33827aff94d8b88865b49e3ea384d

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Akademický článek

Dietary Macronutrient Composition Differentially Modulates the Remodeling of Mitochondrial Oxidative Metabolism during NAFLD

Autor: Nathan Kattapuram, Christine Zhang, Muhammed S. Muyyarikkandy, Chaitra Surugihalli, Vaishna Muralidaran, Tabitha Gregory, Nishanth E. Sunny

Publikováno v: Metabolites, Vol 11, Iss 5, p 272 (2021)

Diets rich in fats and carbohydrates aggravate non-alcoholic fatty liver disease (NAFLD), of which mitochondrial dysfunction is a central feature. It is not clear whether a high-carbohydrate driven ‘lipogenic’ diet differentially affects mitochon

Externí odkaz: https://doaj.org/article/84c54e448c914686b6e505878ac2c233

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Akademický článek

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver[S]

Autor: Santhosh Satapati, Nishanth E. Sunny, Blanka Kucejova, Xiaorong Fu, Tian Teng He, Andrés Méndez-Lucas, John M. Shelton, Jose C. Perales, Jeffrey D. Browning, Shawn C. Burgess

Publikováno v: Journal of Lipid Research, Vol 53, Iss 6, Pp 1080-1092 (2012)

The manner in which insulin resistance impinges on hepatic mitochondrial function is complex. Although liver insulin resistance is associated with respiratory dysfunction, the effect on fat oxidation remains controversial, and biosynthetic pathways t

Externí odkaz: https://doaj.org/article/ba94d3a6be124555b8986617945852ef

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Branched-chain amino acids alter cellular redox to induce lipid oxidation and reduce de novo lipogenesis in the liver

Autor: Chaitra Surugihalli, Vaishna Muralidaran, Caitlin E. Ryan, Kruti Patel, David Zhao, Nishanth E. Sunny

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 324:E299-E313

Branched-chain amino acids (BCAAs) have been shown to modulate lipid metabolic networks in various tissues, especially during insulin resistance. In this study we show that the dietary supplementation of BCAAs to normal, insulin-sensitive mice result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::090350552dcd3af524a119428e26dee9
https://doi.org/10.1152/ajpendo.00307.2022

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