Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nishanth, Kuganesan"'
Autor:
Riddhidev, Banerjee, Endri, Karaj, Sabitri, Lamichhane, Kotsull, Lauren, N., Nishanth, Kuganesan, Dragan, Isailovic, Mary Kay H, Pflum, James, Slama, William, Taylor, L. M. Viranga, Tillekeratne
Publikováno v:
In European Journal of Medicinal Chemistry 15 December 2022 244
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Radhika A. Koranne, Joseph R. Knoff, Antonisamy William James, Yu Fu, Lauren N. Kotsull, Mary Kay Pflum, Zahoor Shah, William R. Taylor, L. M. Viranga Tillekeratne
Publikováno v:
Journal of Medicinal Chemistry. 65:14764-14791
HDAC inhibitors are an attractive class of cytotoxic agents for the design of hybrid molecules. Several HDAC hybrids have emerged over the years, but none combines HDAC inhibition with ferroptosis, a combination which is being extensively studied bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4664fff8226159824204e3ba7728ff
https://doi.org/10.1021/acs.jmedchem.2c01276
https://doi.org/10.1021/acs.jmedchem.2c01276
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Lalith Perera, William Taylor, L. M. Viranga Tillekeratne
Publikováno v:
Journal of Medicinal Chemistry. 65:11788-11817
Once considered potential liabilities, the modern era witnesses a renaissance of interest in covalent inhibitors in drug discovery. The available toolbox of electrophilic warheads is limited by constraints on tuning reactivity and selectivity. Follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc21fb990e1b98b1e826d50ea07298c
https://doi.org/10.1021/acs.jmedchem.2c00909
https://doi.org/10.1021/acs.jmedchem.2c00909
Autor:
Samkeliso Dlamini, William R. Taylor, Viranga Tillekeratne, Jade McDaniel, Nishanth Kuganesan
Publikováno v:
J Cell Biochem
Ferroptosis is a form of iron-dependent cell death characterized by elevated lipid peroxides and reactive oxygen species (ROS). Glutathione (GSH) plays an essential role in scavenging ROS to maintain cell viability and acts as a cofactor of GSH perox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d102fad53158ed0023fa75c66620484d
https://doi.org/10.1002/jcb.29870
https://doi.org/10.1002/jcb.29870
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Lalith Perera, William Taylor, L. M. Viranga Tillekeratne
Covalent inhibitors have historically been considered potential liabilities in medicinal chemistry. The modern era witnesses a renaissance of interest in irreversible binders. The available toolbox of electrophilic warheads is limited with constraint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::119551cc470b4369e3445611d1ac4f33
https://doi.org/10.26434/chemrxiv-2022-h9t07
https://doi.org/10.26434/chemrxiv-2022-h9t07
Publikováno v:
Journal of Biological Chemistry. 299:103928
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5f1f90db3e8fe36a7bc81f88930c616
https://doi.org/10.1016/j.jbc.2023.103928
https://doi.org/10.1016/j.jbc.2023.103928
Publikováno v:
J Biol Chem
p53 is a well-established critical cell cycle regulator. By inducing transcription of the gene encoding p21, p53 inhibits cyclin-dependent kinase (CDK)-mediated phosphorylation of cell cycle inhibitor retinoblastoma (RB) proteins. Phosphorylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9902b3d7779ff522f4b713d201793b
https://doi.org/10.1016/j.jbc.2021.101365
https://doi.org/10.1016/j.jbc.2021.101365
Autor:
Samkeliso Dlamini, Sara R. Fedorka, Maisha S. Rashid, William R. Taylor, Veronika Kholodovych, Radhika Koranne, Mark W. Jackson, Tim Rogers, Ayad A. Al-Hamashi, Ibtissam Gad, Damian J. Junk, L. M. Viranga Tillekeratne, Nishanth Kuganesan, Yusuf Barudi, Hanan D. Alqahtani, Ronit Shah
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Effective management of advanced cancer requires systemic treatment including small molecules that target unique features of aggressive tumor cells. At the same time, tumors are heterogeneous and current evidence suggests that a subpopulation of tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590798b82c669209feb94b0dcf2199c2
https://pubmed.ncbi.nlm.nih.gov/30976078
https://pubmed.ncbi.nlm.nih.gov/30976078