Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Nishant Singhal"'
Autor:
Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-20 (2023)
Abstract Background Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberrant activation of signa
Externí odkaz:
https://doaj.org/article/498fc8f55a7740ddb406c597bd1c777b
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/18b246f84d774fe29465e6013ff81ae7
Publikováno v:
Stem Cell Research, Vol 67, Iss , Pp 103041- (2023)
A pair of Down syndrome (DS) human iPSCs (hiPSCs) and isogenic euploid hiPSCs generated by using an integration-free Sendai viral vector system showed trisomy 21 (47; XY) and typical (46; XY) karyotype respectively. Pluripotency of both hiPSC lines w
Externí odkaz:
https://doaj.org/article/0c6cef5290cd4564b202b4a674f6cc15
Autor:
Vishi Sharma, Sunita Nehra, Long H. Do, Anwesha Ghosh, Aniruddha J. Deshpande, Nishant Singhal
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Impaired neurogenesis in Down syndrome (DS) is characterized by reduced neurons, increased glial cells, and delayed cortical lamination. However, the underlying cause for impaired neurogenesis in DS is not clear. Using both human and mouse iPSCs, we
Externí odkaz:
https://doaj.org/article/5fc1e41d38dd486bb2101ef0df8c8705
Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102890- (2022)
Human mouse chimeric models are valuable tools to develop in-vivo disease models. However, in-vivo detection of human cells limits their analysis. To facilitate in-vivo modeling of Down syndrome (DS), we generated a stable AAVS1-EGFP isogenic pair of
Externí odkaz:
https://doaj.org/article/a4a16b0d66524ffaba7f2f4f12e47c26
Publikováno v:
Stem Cell Research, Vol 61, Iss , Pp 102771- (2022)
Human-induced pluripotent stem cells (hiPSCs) clones NSi001-A, NSi001-B, and NSi001-C were generated from a female individual of Indian origin having Robertsonian translocation down syndrome (DS) by reprogramming peripheral blood mononuclear cells (P
Externí odkaz:
https://doaj.org/article/805c3e82041d4910a6d796bd8baca472
Autor:
Gabriele Wagner, Nishant Singhal, Dario Nicetto, Tobias Straub, Elisabeth Kremmer, Ralph A W Rupp
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006757 (2017)
Zygotic gene expression programs control cell differentiation in vertebrate development. In Xenopus, these programs are initiated by local induction of regulatory genes through maternal signaling activities in the wake of zygotic genome activation (Z
Externí odkaz:
https://doaj.org/article/984f0d6506b64663b5e8539ef6b9aa45
Autor:
Pavel V Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, Adeline Plassard, Stephanie Vuillermot, Valérie Giriens, Rachel L Nosheny, Alexander M Kleschevnikov, Janice S Valletta, Sara K S Bengtsson, Gordon R Linke, Michael T Maloney, David T Hickman, Pedro Reis, Anne Granet, Dorin Mlaki, Maria Pilar Lopez-Deber, Long Do, Nishant Singhal, Eliezer Masliah, Matthew L Pearn, Andrea Pfeifer, Andreas Muhs, William C Mobley
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152471 (2016)
In Down syndrome (DS) or trisomy of chromosome 21, the β-amyloid (Aβ) peptide product of the amyloid precursor protein (APP) is present in excess. Evidence points to increased APP gene dose and Aβ as playing a critical role in cognitive difficulti
Externí odkaz:
https://doaj.org/article/e6e5615e619c41a0ad64eafb049c71c7
Publikováno v:
F1000Research, Vol 4 (2015)
Recently, in studies examining fibroblasts obtained from the tissues of one set of monozygotic twins (i.e. fetuses derived from the same egg) discordant for trisomy 21 (Down syndrome; DS), Letourneau et al., reported the presence of a defined pattern
Externí odkaz:
https://doaj.org/article/14aa2431486849859941d4f5d6fefbad
Publikováno v:
BioResearch Open Access, Vol 3, Iss 1, Pp 1-8 (2014)
BioResearch Open Access
BioResearch Open Access
BAF chromatin remodeling complexes containing the BRG1 protein have been shown to be not only essential for early embryonic development, but also paramount in enhancing the efficiency of reprogramming somatic cells to pluripotency mediated by four tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70885739ad05e0d5ae3f0eacdb05836e
https://www.liebertpub.com/doi/full/10.1089/BIORES.2013.0047
https://www.liebertpub.com/doi/full/10.1089/BIORES.2013.0047