Passive transfer of fibromyalgia symptoms from patients to mice

Autor: Joana Menezes, Yuki Nomura, Camilla I. Svensson, Angelica Sandström, Stuart Bevan, Margot Maurer, Azar Baharpoor, Nisha Vastani, David Andersson, Alexandra Jurczak, Lisbet Haglund, Clive Gentry, Andreas Goebel, Mathilde R. Israel, Louisa Brieskorn, Diana Kadetoff, Emerson Krock, Carlos Morado Urbina, Ulku Cuhadar, Eva Kosek, Serena Sensi, Katalin Sandor, Jeanette Tour

Publikováno v: The Journal of Clinical Investigation
JOURNAL OF CLINICAL INVESTIGATION

Fibromyalgia syndrome (FMS) is a chronic pain condition characterized by widespread pain, augmented pain sensitivity to mechanical pressure and cold temperatures (1–4), as well as fatigue and emotional distress (5–7). The prevalence of FMS is at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982f4dcd7a5ec19ca02f5fa47b889a4b

Methylglyoxal evokes pain by stimulating TRPA1.

Autor: David A Andersson, Clive Gentry, Emily Light, Nisha Vastani, Julie Vallortigara, Angelika Bierhaus, Thomas Fleming, Stuart Bevan

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77986 (2013)

Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound methyl

Externí odkaz: https://doaj.org/article/3e1624368ac4447fa95f002ffdc217ec

Autoantibodies produce pain in complex regional pain syndrome by sensitizing nociceptors

Autor: Nisha Vastani, Ulku Cuhadar, Andreas Goebel, Stuart Bevan, Serena Sensi, David Andersson, Clive Gentry

Publikováno v: Cuhadar, U, Gentry, C, Vastani, N, Sensi, S, Bevan, S, Goebel, A & Andersson, D 2019, ' Autoantibodies produce pain in Complex Regional Pain Syndrome by sensitizing nociceptors ', Pain, vol. 160, no. 12, pp. 2855-2865 . https://doi.org/10.1097/j.pain.0000000000001662
Pain

Complex regional pain syndrome (CRPS) is a post-traumatic pain condition with an incompletely understood pathophysiological basis. Here, we have examined the cellular basis of pain in CRPS using behavioral and electrophysiological methods in mice tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e7f4fdb4ab16673c2f3b5ae8bbc93a
https://pubmed.ncbi.nlm.nih.gov/31343542

Streptozotocin Stimulates the Ion Channel TRPA1 Directly

Autor: David Andersson, Nisha Vastani, Stuart Bevan, Andreas Leffler, Milos R. Filipovic, Peter W. Reeh, Mirjam Eberhardt, Clive Gentry

Publikováno v: Journal of Biological Chemistry. 290:15185-15196

Streptozotocin (STZ)-induced diabetes is the most commonly used animal model of diabetes. Here, we have demonstrated that intraplantar injections of low dose STZ evoked acute polymodal hypersensitivities in mice. These hypersensitivities were inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3b6f150e4fff70586bc2b7dce645890
https://doi.org/10.1074/jbc.m115.644476

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel

Autor: Gregory Dussor, Nisha Vastani, Romina Nassini, Pierangelo Geppetti, Gaetano De Siena, Federica Pollastro, Xiaomei Wei, Giovanni Appendino, Silvia Benemei, Riccardo Patacchini, David Andersson, Roberta Gualdani, Gabriela Trevisan, Serena Materazzi, Camilla Fusi, Maria Rosa Moncelli

Publikováno v: Pain. 154:2750-2758

Although feverfew has been used for centuries to treat pain and headaches and is recommended for migraine treatment, the mechanism for its protective action remains unknown. Migraine is triggered by calcitonin gene-related peptide (CGRP) release from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df34f173167d7cf174e29afef406873
https://doi.org/10.1016/j.pain.2013.08.002