Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Nisha S. Sipes"'
Publikováno v:
Journal of Statistical Software, Vol 79, Iss 1, Pp 1-26 (2017)
Thousands of chemicals have been profiled by high-throughput screening programs such as ToxCast and Tox21; these chemicals are tested in part because most of them have limited or no data on hazard, exposure, or toxicokinetics. Toxicokinetic models ai
Externí odkaz:
https://doaj.org/article/d0f38d71a0bb4c80b1e23e1196fb56fd
Autor:
Stephanie L. Smith‐Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy, Jamie E. Sly, Xiaoqing Chang, Nisha S. Sipes, Keith R. Shockley, Shawn F. Harris, Sandra J. McBride, Gary J. Larson, Bradley J. Collins, Esra Mutlu, Kristine L. Witt
Publikováno v:
Environmental and Molecular Mutagenesis. 64:202-233
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd2947f3d2db52a359f6a1c16546e9bf
https://doi.org/10.1002/em.22534
https://doi.org/10.1002/em.22534
Autor:
Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N Hardwick, Stephen S Ferguson, Jason P Stanko, Piyush Bajaj, Karissa Adkins, Nisha S Sipes, E Sidney Hunter, Maria T Baltazar, Paul L Carmichael, Kritika Sadh, Richard A Becker
Publikováno v:
Toxicol Sci
Much has been written and said about the promise and excitement of microphysiological systems, miniature devices that aim to recreate aspects of human physiology on a chip. The rapid explosion of the offerings and persistent publicity placed high exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fe00b5247331ff1b276233e30fd420
https://pubmed.ncbi.nlm.nih.gov/35689632
https://pubmed.ncbi.nlm.nih.gov/35689632
Autor:
Gregory S Honda, Robert G Pearce, Ly L Pham, R W Setzer, Barbara A Wetmore, Nisha S Sipes, Jon Gilbert, Briana Franz, Russell S Thomas, John F Wambaugh
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217564 (2019)
Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologic
Externí odkaz:
https://doaj.org/article/dd304bfaf4ec40dcb06257731d4d94e3
Autor:
Stephen S. Ferguson, Julie R. Rice, Bruce Alex Merrick, Paul E Dunlap, Michael J. DeVito, Nisha S. Sipes, David Crizer, Sreenivasa Ramaiahgari, Scott S. Auerbach
Publikováno v:
Toxicol Sci
Interpretation of untargeted metabolomics data from both in vivo and physiologically relevant in vitro model systems continues to be a significant challenge for toxicology research. Potency-based modeling of toxicological responses has served as a pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc5e17d52788dbc270613859209560f
https://doi.org/10.1093/toxsci/kfab036
https://doi.org/10.1093/toxsci/kfab036
Autor:
Martijn J Moné, Takashi Yamada, Costanza Rovida, Andrew White, Bob van de Water, Leon van Aerts, Susanne Hougaard Bennekou, Grace Patlewicz, Matthias Herzler, Lidka Maslankiewicz, Sylvia Escher, Dinant Kroese, Hennicke Kamp, Nisha S. Sipes
Publikováno v:
ALTEX
Rovida, C, Escher, S E, Herzler, M, Bennekou, S H, Kamp, H, Kroese, D E, Maslankiewicz, L, Moné, M J, Patlewicz, G, Sipes, N, Van Aerts, L, White, A, Yamada, T & Van de Water, B 2021, ' NAM-supported read-across : From case studies to regulatory guidance in safety assessment ', A L T E X. Alternatives to Animal Experimentation, vol. 38, no. 1, pp. 140-150 . https://doi.org/10.14573/altex.2010062
ALTEX : Alternatives to Animal Experimentation, 38(1), 140-150
Rovida, C, Escher, S E, Herzler, M, Bennekou, S H, Kamp, H, Kroese, D E, Maslankiewicz, L, Moné, M J, Patlewicz, G, Sipes, N, Van Aerts, L, White, A, Yamada, T & Van de Water, B 2021, ' NAM-supported read-across : From case studies to regulatory guidance in safety assessment ', A L T E X. Alternatives to Animal Experimentation, vol. 38, no. 1, pp. 140-150 . https://doi.org/10.14573/altex.2010062
ALTEX : Alternatives to Animal Experimentation, 38(1), 140-150
The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project. To bring this forward, EU-ToxRisk partners convened a workshop in close collaboration with regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1118af309a713f8d5af8271a36a175f8
https://doi.org/10.14573/altex.2010062
https://doi.org/10.14573/altex.2010062
Autor:
John F. Wambaugh, Mark Sfeir, Heather A. Pangburn, Jeffery M. Gearhart, Risa Sayre, Nisha S. Sipes, Matthew W. Linakis, Robert G. Pearce
Publikováno v:
Journal of exposure science & environmental epidemiology
Currently it is difficult to prospectively estimate human toxicokinetics (particularly for novel chemicals) in a high-throughput manner. The R software package httk has been developed, in part, to address this deficiency, and the aim of this investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b756c8b757a187c506f828907ae6b8
http://europepmc.org/articles/PMC7483974
http://europepmc.org/articles/PMC7483974
Autor:
Barbara D. Abbott, David G. Belair, Nisha S. Sipes, Nancy C. Baker, Thomas B. Knudsen, Richard S. Judson, Jill A Franzosa
Publikováno v:
Birth Defects Res
Cleft palate has been linked to both genetic and environmental factors that perturb key events during palatal morphogenesis. As a developmental outcome, it presents a challenging, mechanistically complex endpoint for predictive modeling. A data set o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a66a6629ca1957bb977fe961e5aeff7
https://doi.org/10.1002/bdr2.1581
https://doi.org/10.1002/bdr2.1581
Autor:
Caroline, Ring, Nisha S, Sipes, Jui-Hua, Hsieh, Celeste, Carberry, Lauren E, Koval, William D, Klaren, Mark A, Harris, Scott S, Auerbach, Julia E, Rager
Publikováno v:
Computational toxicology (Amsterdam, Netherlands)
Computational methods are needed to more efficiently leverage data from in vitro cell-based models to predict what occurs within whole body systems after chemical insults. This study set out to test the hypothesis that in vitro high-throughput screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::320d5f493e50f1e82e26e09db01f38e3
https://pubmed.ncbi.nlm.nih.gov/34013136
https://pubmed.ncbi.nlm.nih.gov/34013136
Autor:
Menghang Xia, Kristen Ryan, Nisha S. Sipes, Masato Ooka, Jinghua Zhao, Michael F. Santillo, Jui-Hua Hsieh, Fengtian Xue, Srilatha Sakamuru, Wenbo Yu, Alexander D. MacKerell, Ruili Huang, Carleen Klumpp-Thomas, Shuaizhang Li, Jameson Travers, Anton Simeonov
Publikováno v:
Environmental Health Perspectives
Background: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. So far, many environmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ee889b061b989962669b29903cce31
https://pubmed.ncbi.nlm.nih.gov/33844597
https://pubmed.ncbi.nlm.nih.gov/33844597