Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nisha S. Ninan"'
Autor:
Gregory D. Van Duyne, Amanda C. Raimer, Kathryn L. Sarachan, Nisha S. Ninan, Kushol Gupta, Meghan C. Johnson, Ying Wen, Ashlyn M. Spring, Robert Sharp, A. Gregory Matera
Publikováno v:
Nucleic Acids Research
Protein oligomerization is one mechanism by which homogenous solutions can separate into distinct liquid phases, enabling assembly of membraneless organelles. Survival Motor Neuron (SMN) is the eponymous component of a large macromolecular complex th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb68e0ccfc19747212d4c76bcd9533c2
https://doi.org/10.1101/2020.11.07.336172
https://doi.org/10.1101/2020.11.07.336172
Autor:
Kathryn L. Sarachan, Robert Sharp, Gregory D. Van Duyne, Nisha S. Ninan, Kushol Gupta, Renee Martin
Publikováno v:
Journal of Biological Chemistry. 290:20185-20199
The survival motor neuron (SMN) protein forms the oligomeric core of a multiprotein complex required for the assembly of spliceosomal small nuclear ribonucleoproteins. Deletions and mutations in the SMN1 gene are associated with spinal muscular atrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1dd6457717ee4a36b00f29a804fb473
https://doi.org/10.1074/jbc.m115.667279
https://doi.org/10.1074/jbc.m115.667279
Autor:
Jeremy M. Travins, Carl Crysler, Hufnagel Heather Rae, Karen DiLoreto, Norman Huebert, Michael X. Kolpak, Nalin L. Subasinghe, Jennifer Kirkpatrick, Stephen H. Eisennagel, Bruce E. Tomczuk, Wenxi Pan, Christopher J. Molloy, Ehab Khalil, Nisha S. Ninan, Shelley K. Ballentine, Kristi A. Leonard, Roger F. Bone, Richard Soll, Farah Ali, Michael D. Gaul
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5303-5307
Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44891a19d07c75d5617cf44b0ba3e337
https://doi.org/10.1016/j.bmcl.2012.06.030
https://doi.org/10.1016/j.bmcl.2012.06.030
Autor:
Renee L. DesJarlais, Hui Huang, Jennifer Kirkpatrick, Nalin L. Subasinghe, Norman Huebert, Gaul Michael David, Nisha S. Ninan, Joan Gushue, Jeremy M. Travins, Bruce E. Tomczuk, Roger F. Bone, Shelley K. Ballentine, Christopher J. Molloy, Kristi A. Leonard, Ehab Khalil, Hufnagel Heather Rae, Farah Ali, Maxwell D. Cummings, Richard M. Soll, Wenxi Pan, Carl Crysler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1603-1606
Complement activation has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury, acute respiratory distress syndrome, and acute transplant rejection. Even though the complement cascade provides several protein t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06eefcfefc962ecd7776e95a4980fdd8
https://doi.org/10.1016/j.bmcl.2008.01.064
https://doi.org/10.1016/j.bmcl.2008.01.064
Autor:
Evan J. Weiner, Nisha S. Ninan, Ronen Marmorstein, Xinmin Li, Frank J. Rauscher, Jesus M. Lopez-Guisa
Publikováno v:
Journal of Biological Chemistry. 272:27324-27329
The BTB/POZ domain defines a conserved region of about 120 residues and has been found in over 40 proteins to date. It is located predominantly at the N terminus of Zn-finger DNA-binding proteins, where it may function as a repression domain, and les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a4c8b65f9e39b4ec22243c112d27b9
https://doi.org/10.1074/jbc.272.43.27324
https://doi.org/10.1074/jbc.272.43.27324
Autor:
Bruce P. Damiano, Tho V Thieu, Thomas P. Markotan, Tianbao Lu, Yu-Kai Lee, Karen L. Milkiewicz, Nisha S. Ninan, David F. McComsey, Daniel J. Parks, Mark R. Player, Bruce E. Maryanoff, Wenxi Pan, Edward C. Giardino, Marta C. Abad, Carl Crysler
Publikováno v:
Journal of medicinal chemistry. 51(2)
We have developed a novel series of potent and selective factor Xa inhibitors that employ a key 7-fluoroindazolyl moiety. The 7-fluoro group on the indazole scaffold replaces the carbonyl group of an amide that is found in previously reported factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b58da6624a5c78fdfd45cb53da201e6
https://pubmed.ncbi.nlm.nih.gov/18159923
https://pubmed.ncbi.nlm.nih.gov/18159923
Autor:
Christopher J. Molloy, Nisha S. Ninan, Jeremy M. Travins, Hui Huang, Carl Crysler, Renee L. DesJarlais, Shelley K. Ballentine, Ehab Khalil, Juan J. Marugan, Farah Ali, Nalin L. Subasinghe, Bruce E. Tomczuk, Hufnagel Heather Rae, Maxwell D. Cummings, Roger F. Bone
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(8)
Inhibiting the classical pathway of complement activation by attenuating the proteolytic activity of the serine protease C1s is a potential strategy for the therapeutic intervention in disease states such as hereditary angioedema, ischemia-reperfusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a587fbead37071b080459e0c763d4a
https://pubmed.ncbi.nlm.nih.gov/16460935
https://pubmed.ncbi.nlm.nih.gov/16460935
Autor:
Lei Qiao, Kevin J. Moriarty, Renee L. DesJarlais, Rolanda L. Reed, John C. Spurlino, Norman Huebert, Bruce E. Tomczuk, Mike P. Neeper, Nisha S. Ninan, Marta C. Abad, Carl Crysler, Ingrid Deckman, Robyn Williams, Christian Andrew Baumann, Malini Dasgupta, Jukka Kervinen, Shariff Bayoumy
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(1)
The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f84d4dc30b1cbb1577577c88b052729
https://pubmed.ncbi.nlm.nih.gov/16236500
https://pubmed.ncbi.nlm.nih.gov/16236500
Publikováno v:
Structure. (11):1929-1939
Summary The survival motor neuron (SMN) protein forms the oligomeric core of a multiprotein complex that functions in spliceosomal snRNP biogenesis. Loss of function mutations in the SMN gene cause spinal muscular atrophy (SMA), a leading genetic cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86beaa332fffd9c32730b0319a908b14