Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions.

Autor: Gregory S Honda, Robert G Pearce, Ly L Pham, R W Setzer, Barbara A Wetmore, Nisha S Sipes, Jon Gilbert, Briana Franz, Russell S Thomas, John F Wambaugh

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217564 (2019)

Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologic

Externí odkaz: https://doaj.org/article/dd304bfaf4ec40dcb06257731d4d94e3

Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay.

Autor: Kelly J Chandler, Marianne Barrier, Susan Jeffay, Harriette P Nichols, Nicole C Kleinstreuer, Amar V Singh, David M Reif, Nisha S Sipes, Richard S Judson, David J Dix, Robert Kavlock, Edward S Hunter, Thomas B Knudsen

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e18540 (2011)

The vast landscape of environmental chemicals has motivated the need for alternative methods to traditional whole-animal bioassays in toxicity testing. Embryonic stem (ES) cells provide an in vitro model of embryonic development and an alternative me

Externí odkaz: https://doaj.org/article/5d5d41f27bda48b6a63e677cabf91696

Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium

Autor: Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N Hardwick, Stephen S Ferguson, Jason P Stanko, Piyush Bajaj, Karissa Adkins, Nisha S Sipes, E Sidney Hunter, Maria T Baltazar, Paul L Carmichael, Kritika Sadh, Richard A Becker

Publikováno v: Toxicol Sci

Much has been written and said about the promise and excitement of microphysiological systems, miniature devices that aim to recreate aspects of human physiology on a chip. The rapid explosion of the offerings and persistent publicity placed high exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fe00b5247331ff1b276233e30fd420
https://pubmed.ncbi.nlm.nih.gov/35689632

NAM-supported read-across: From case studies to regulatory guidance in safety assessment

Autor: Martijn J Moné, Takashi Yamada, Costanza Rovida, Andrew White, Bob van de Water, Leon van Aerts, Susanne Hougaard Bennekou, Grace Patlewicz, Matthias Herzler, Lidka Maslankiewicz, Sylvia Escher, Dinant Kroese, Hennicke Kamp, Nisha S. Sipes

Publikováno v: ALTEX
Rovida, C, Escher, S E, Herzler, M, Bennekou, S H, Kamp, H, Kroese, D E, Maslankiewicz, L, Moné, M J, Patlewicz, G, Sipes, N, Van Aerts, L, White, A, Yamada, T & Van de Water, B 2021, ' NAM-supported read-across : From case studies to regulatory guidance in safety assessment ', A L T E X. Alternatives to Animal Experimentation, vol. 38, no. 1, pp. 140-150 . https://doi.org/10.14573/altex.2010062
ALTEX : Alternatives to Animal Experimentation, 38(1), 140-150

The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project. To bring this forward, EU-ToxRisk partners convened a workshop in close collaboration with regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1118af309a713f8d5af8271a36a175f8
https://doi.org/10.14573/altex.2010062

Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature

Autor: Barbara D. Abbott, David G. Belair, Nisha S. Sipes, Nancy C. Baker, Thomas B. Knudsen, Richard S. Judson, Jill A Franzosa

Publikováno v: Birth Defects Res

Cleft palate has been linked to both genetic and environmental factors that perturb key events during palatal morphogenesis. As a developmental outcome, it presents a challenging, mechanistically complex endpoint for predictive modeling. A data set o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a66a6629ca1957bb977fe961e5aeff7
https://doi.org/10.1002/bdr2.1581