Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nisha Narayan"'
Autor:
J. Julie Wu, Jie Liu, Edmund B. Chen, Jennifer J. Wang, Liu Cao, Nisha Narayan, Marie M. Fergusson, Ilsa I. Rovira, Michele Allen, Danielle A. Springer, Cory U. Lago, Shuling Zhang, Wendy DuBois, Theresa Ward, Rafael deCabo, Oksana Gavrilova, Beverly Mock, Toren Finkel
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 913-920 (2013)
We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse model. Mice with two hypomorphic (mTORΔ/Δ) alleles are viable but express mTOR at approximately 25% of wild-type levels. These animals demonstrate reduced
Externí odkaz:
https://doaj.org/article/8213b697016544c1aff5a5dfc267de9f
Autor:
Oliver M. Dovey, Pedro Madrigal, Paolo Gallipoli, George S. Vassiliou, Haiyang Yun, Cameron S. Osborne, Shuchi Agrawal-Singh, Annalisa Mupo, Shabana Vohra, David Lara-Astiaso, Aracely Castillo-Venzor, Faisal Basheer, Sarah J. Horton, Brian J. P. Huntly, Ludovica Marando, Malgorzata Gozdecka, Eshwar Meduri, Carsten Müller-Tidow, Daniel Sasca, George Giotopoulos, Xiaonan Wang, Nisha Narayan
Publikováno v:
Nature Genetics. 53:1443-1455
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic appro
Autor:
Nisha Narayan, Brian Huntly
Publikováno v:
Science Signaling. 15
Mutations in multiple cancers may synergize to alter the cellular epigenetic and transcriptional state and corrupt key signaling pathways. In this issue of Science Signaling , Pedicona et al. illustrate how the two processes intersect to regulate cel
Publikováno v:
Experimental Hematology. 62:1-6
Acute myeloid leukemia (AML) arises when immature myeloid blast cells acquire multiple, recurrent genetic and epigenetic changes that result in dysregulated proliferation. Acute leukemia is the most common form of pediatric cancer, with AML accountin
Autor:
Harshal Hanumant Nandurkar, Meaghan Wall, Heung-Chin Cheng, Carl R. Walkley, Nisha Narayan, Matthew Ku, Louise E. Purton, Ruth N. MacKinnon, Lynda J. Campbell
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological malignancies. It is detected in 10% of myeloproliferative neoplasms, 4–5% of myelodysplastic syndromes, and 1–2% of ac
Autor:
Laura E. Edgington, Lahiru Gangoda, Hamsa Puthalakath, Rahul Srivastava, Christine J. Hawkins, Nisha Narayan, Andreas Strasser, Paul G Ekert, Jacqueline M. Orian, Marcel Doerflinger, Matthew Bogyo, Lorraine A. O'Reilly, H Gu
Publikováno v:
Cell Death & Differentiation. 21:1815-1824
Loss of function mutations in the Prkar1a gene are the cause of most cases of Carney complex disorder. Defects in Prkar1a are thought to cause hyper-activation of PKA signalling, which drives neoplastic transformation, and Prkar1a is therefore consid
Autor:
Ilsa I. Rovira, J. Julie Wu, Rafael deCabo, Marie M. Fergusson, Nisha Narayan, Toren Finkel, Oksana Gavrilova, Danielle A. Springer, Jennifer J. Wang, Michele D. Allen, Edmund Chen, Liu Cao, Cory U. Lago, Beverly A. Mock, Wendy Dubois, Shuling Zhang, Theresa H. Ward, Jie Liu
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 913-920 (2013)
We analyzed a new hypomorphic mouse model containing a targeted intronic insertion of a neomycin cassette within the mechanistic target of rapamycin (mTOR) locus. Mice with two hypomorphic (mTORΔ/Δ) alleles are viable but express mTOR at approximat
Autor:
Fredrick W. Alt, Marjan Gucek, Elizabeth Murphy, Guanghui Wang, Guang Tong, In Hye Lee, Renee Wong, Ilsa I. Rovira, Nisha Narayan, Jie Liu, Ronen Borenstein, Toren Finkel, Hwei Ling Cheng, Michael N. Sack, Junhui Sun, Maria M. Fergusson, Liu Cao, David B. Lombard
Publikováno v:
Nature. 492:199-204
Although initially viewed as unregulated, increasing evidence suggests that cellular necrosis often proceeds through a specific molecular program. In particular, death ligands such as tumour necrosis factor (TNF)-α activate necrosis by stimulating t
Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 biogenesis, is overexpressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8fd4f42d97a89dc95f9707126a680e
https://europepmc.org/articles/PMC5136483/
https://europepmc.org/articles/PMC5136483/
Publikováno v:
Journal of Cell Science. 122:65-74
The Discs Large (Dlg) protein is known to be involved in the regulation of cellular proliferation and polarity in a variety of tissues. The human homologue DLG1 is thought to be a tumour suppressor, through formation of a complex with the APC (adenom