Metagenomic features of bioburden serve as outcome indicators in combat extremity wounds

Autor: Aram Avila-Herrera, James B. Thissen, Nisha Mulakken, Seth A. Schobel, Michael D. Morrison, Xiner Zhou, Scott F. Grey, Felipe A. Lisboa, Desiree Unselt, Shalini Mabery, Meenu M. Upadhyay, Crystal J. Jaing, Eric A. Elster, Nicholas A. Be

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract Battlefield injury management requires specialized care, and wound infection is a frequent complication. Challenges related to characterizing relevant pathogens further complicates treatment. Applying metagenomics to wounds offers a comprehe

Externí odkaz: https://doaj.org/article/071e4af3fffd4b6ca0ac969213e2a999

Multiple Mutations Associated with Emergent Variants Can Be Detected as Low-Frequency Mutations in Early SARS-CoV-2 Pandemic Clinical Samples

Autor: Jeffrey Kimbrel, Joseph Moon, Aram Avila-Herrera, Jose Manuel Martí, James Thissen, Nisha Mulakken, Sarah H. Sandholtz, Tyshawn Ferrell, Chris Daum, Sara Hall, Brent Segelke, Kathryn T. Arrildt, Sharon Messenger, Debra A. Wadford, Crystal Jaing, Jonathan E. Allen, Monica K. Borucki

Publikováno v: Viruses, Vol 14, Iss 12, p 2775 (2022)

Genetic analysis of intra-host viral populations provides unique insight into pre-emergent mutations that may contribute to the genotype of future variants. Clinical samples positive for SARS-CoV-2 collected in California during the first months of t

Externí odkaz: https://doaj.org/article/7c6bb0b59fab4de1938f30df1584448c

A functional gene array for detection of bacterial virulence elements.

Autor: Crystal Jaing, Shea Gardner, Kevin McLoughlin, Nisha Mulakken, Michelle Alegria-Hartman, Phillip Banda, Peter Williams, Pauline Gu, Mark Wagner, Chitra Manohar, Tom Slezak

Publikováno v: PLoS ONE, Vol 3, Iss 5, p e2163 (2008)

Emerging known and unknown pathogens create profound threats to public health. Platforms for rapid detection and characterization of microbial agents are critically needed to prevent and respond to disease outbreaks. Available detection technologies

Externí odkaz: https://doaj.org/article/e22c83e6c86a44558a049c5b58680793

Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases

Autor: Jia Lu, Isaac Boateng, Donatus I Adomeh, Margaret Lamunu, Oliver G. Pybus, Brima Kargbo, Patrick Otim, Andreas Kurth, Nuno R. Faria, Alimamy Tarawalie, Abdul Kamara, Patience Akhilomen, Elisabetta Groppelli, John T. Redd, Esther Vitto, Matthew Newport, Umaru Jah, Daniel Cooper, Tim Brooks, Andrew J. H. Simpson, Lucy Thorne, Ekaete Alice Tobin, Jake Dunning, Lawrence Okoror, Solomon Ehikhiametalor, Brima Osaio Kamara, Dhamari Naidoo, Sahr Sm Gevao, Guoying Liu, Chris Aire, Martin Gabriel, Andrew Rambaut, Zabulon Yoti, Armando Arias, Peter Horby, Kate Rhodes, Ian Goodfellow, Roman Wölfel, Jan Baumann, Jennifer Oyakhilome, Miles W. Carroll, Racheal Omiunu, Paul Kellam, James Akpablie, Stephan Günther, Raoul Emeric Guetiya Wadoum, Nisha Mulakken, Gytis Dudas, Simon J. Watson, Simon Dellicour, Foday Sahr, Matthew Cotten, Luke Meredith, Emmanuel Omomoh, My V. T. Phan, Collins Owilli, Ighodalo Yemisis, Pinky Langat, Danny Asogun, Antonino Di Caro, Nicola Cook, Sarah Sl Caddy

Publikováno v: Virus Evolution
Virus evolution, 2 (1
Arias, A, Watson, S J, Asogun, D, Tobin, E A, Lu, J, Phan, M V T, Jah, U, Wadoum, R E G, Meredith, L, Thorne, L, Caddy, S, Tarawalie, A, Langat, P, Dudas, G, Faria, N R, Dellicour, S, Kamara, A, Kargbo, B, Kamara, B O, Gevao, S, Cooper, D, Newport, M, Horby, P, Dunning, J, Sahr, F, Brooks, T, Simpson, A J H, Groppelli, E, Liu, G, Mulakken, N, Rhodes, K, Akpablie, J, Yoti, Z, Lamunu, M, Vitto, E, Otim, P, Owilli, C, Boateng, I, Okoror, L, Omomoh, E, Oyakhilome, J, Omiunu, R, Yemisis, I, Adomeh, D, Ehikhiametalor, S, Akhilomen, P, Aire, C, Kurth, A, Cook, N & Rambaut, A 2016, ' Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases ', Virus Evolution, vol. 2, no. 1, vew016 . https://doi.org/10.1093/ve/vew016

To end the largest known outbreak of Ebola virus disease (EVD) in West Africa and to prevent new transmissions, rapid epidemiological tracing of cases and contacts was required. The ability to quickly identify unknown sources and chains of transmissi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f856ed52e0bdfadd17ee8c186117bd

The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is predictive of colon DNA adducts after a low-dose exposure in humans

Autor: Nisha Mulakken, Susan Nowell-Kadlubar, Karen H. Dingley, Nicholas P. Lang, Kenneth W. Turteltaub, Michael A. Malfatti, David O. Nelson, Esther A. Ubick, James S. Felton

Publikováno v: Cancer research. 66(21)

Epidemiologic evidence indicates that exposure to heterocyclic amines in the diet is an important risk factor for the development of colon cancer. Well-done cooked meats contain significant levels of heterocyclic amines, which have been shown to caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd598a56ab454a0e7125953ad8669e6
https://pubmed.ncbi.nlm.nih.gov/17079477