Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Nisha Jain Garg"'
Autor:
Lizette Elaine Rios, Nandadeva Lokugamage, Subhadip Choudhuri, Imran Hussain Chowdhury, Nisha Jain Garg
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract This study investigated a candidate vaccine effect against maternal Trypanosoma cruzi (Tc) infection and improved pregnancy outcomes. For this, TcG2 and TcG4 were cloned in a nanoplasmid optimized for delivery, antigen expression, and regula
Externí odkaz:
https://doaj.org/article/da8a948a474542299f999812a3b2f2f7
Autor:
Nandadeva Lokugamage, Imran H. Chowdhury, Ronald J. Biediger, Robert V. Market, Sayadeth Khounlo, Navin D. Warier, Shen-An Hwang, Jeffrey K. Actor, Darren G. Woodside, Upendra Marathi, Peter Vanderslice, Nisha Jain Garg
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract The development of suitable safe adjuvants to enhance appropriate antigen-driven immune responses remains a challenge. Here we describe the adjuvant properties of a small molecule activator of the integrins αLβ2 and α4β1, named 7HP349, w
Externí odkaz:
https://doaj.org/article/fa56993f549b4cbda0b8eb8236c01b18
Autor:
Subhadip Choudhuri, Suresh K. Bhavnani, Weibin Zhang, Valentina Botelli, Natalia Barrientos, Facundo Iñiguez, Maria Paola Zago, Nisha Jain Garg
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT Biomarkers for prognosis-based detection of Trypanosoma cruzi-infected patients presenting no clinical symptoms to cardiac Chagas disease (CD) are not available. In this study, we examined the performance of seven biomarkers in prognosis and
Externí odkaz:
https://doaj.org/article/60ab577184df4a03afe3259d76fc6a18
Autor:
Xianxiu Wan, Nisha Jain Garg
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Trypanosoma cruzi is a digenetic parasite that requires triatomines and mammalian host to complete its life cycle. T. cruzi replication in mammalian host induces immune-mediated cytotoxic proinflammatory reactions and cellular injuries, which are the
Externí odkaz:
https://doaj.org/article/1c979c5a6d404f558cbc70c84e6ecf8a
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Innate immune cells play the first line of defense against pathogens. Phagocytosis or invasion by pathogens can affect mitochondrial metabolism in macrophages by diverse mechanisms and shape the macrophage response (proinflammatory vs. immunomodulato
Externí odkaz:
https://doaj.org/article/e3b6da54f71c49658c2e168c18ed2d20
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
A parasitic protozoan Trypanosoma cruzi (T. cruzi) is the etiologic agent of Chagas disease. Previously, we have identified T. cruzi antigens TcG2 and TcG4 as potential vaccine candidates, cloned in eukaryotic expression vector pCDNA3.1 (referred as
Externí odkaz:
https://doaj.org/article/19152b1d08fa41c281c2356ed198968b
Autor:
Subhadip Choudhuri, Nisha Jain Garg
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Chagas disease (CD), caused by Trypanosoma cruzi, is a degenerative heart condition. In the present study, we investigated the role of poly [ADP-ribose] polymerase 1/activator protein 1 (PARP1/AP-1) in upregulation of profibrotic macrophages
Externí odkaz:
https://doaj.org/article/a95f59a9256c410c8c53072444f27831
Autor:
Subhadip Choudhuri, Nisha Jain Garg
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008474 (2020)
Trypanosoma cruzi (T. cruzi) is the etiological agent of Chagas cardiomyopathy. In the present study, we investigated the role of extracellular vesicles (Ev) in shaping the macrophage (Mφ) response in progressive Chagas disease (CD). We purified T.
Externí odkaz:
https://doaj.org/article/1dcb997e3e4c4fc5a2f4a86c21034ab9
Autor:
Shivali Gupta, Berenice Salgado-Jiménez, Nandadeva Lokugamage, Juan Carlos Vázquez-Chagoyán, Nisha Jain Garg
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). Two antigenic candidates, TcG2 and TcG4, are recognized by antibodies in naturally infected dogs and humans; and these vaccine candidates provided protection from Tc infection in
Externí odkaz:
https://doaj.org/article/c455e81e63cb4a1887fb49f3c8204497
Autor:
Maria Paola Zago, John E. Wiktorowicz, Heidi Spratt, Sue-Jie Koo, Natalia Barrientos, Aida Nuñez Burgos, Julio Nuñez Burgos, Facundo Iñiguez, Valentina Botelli, Ricardo Leon de la Fuente, Nisha Jain Garg
Publikováno v:
Frontiers in Microbiology, Vol 9 (2019)
Trypanosoma cruzi (Tc) infection causes Chagas disease (ChD) presented by dilated cardiomyopathy and heart failure. During infection, oxidative and nitrosative stresses are elicited by the immune cells for control the pathogen; however, excess nitric
Externí odkaz:
https://doaj.org/article/ba9f0c8e141844b595928b17e99679d8