Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nisha Gokul"'
Autor:
Diana L. Moreno, Mikayla S. Borthwick, Leah Peralta, Wai Kin Chan, Brenda Melendez, Qian Zhang, Nisha Gokul, Melinda S. Yates
Publikováno v:
Cancer Prevention Research. 16:P015-P015
Background: Lynch syndrome (LS) is a hereditary cancer syndrome carrying roughly 60% lifetime risk of endometrial cancer (EC) development. LS-EC is caused by mutations in mismatch repair genes (most commonly MSH2), which lead to DNA repair deficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9928e91bca1a2f657e06d05d35786f8a
https://doi.org/10.1158/1940-6215.precprev22-p015
https://doi.org/10.1158/1940-6215.precprev22-p015
Autor:
Yang Xin Fu, Nidhi Gupta, Powel Crosley, Michael Weinfeld, Mary M. Hitt, Abul K. Azad, Stephanie A. Pangas, Nisha Gokul, Lynne-Marie Postovit, Huachen Chen, Zhihua Xu
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 14
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3471 (2019)
Volume 20
Issue 14
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3471 (2019)
Granulosa cell tumors of the ovary (GCT) are the predominant type of ovarian sex cord/stromal tumor. Although prognosis is generally favorable, the outcome for advanced and recurrent GCT is poor. A better understanding of the molecular pathogenesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3ca06c2df4a9bc9cfac008ee43f11d
Autor:
Russell Broaddus, Daniel J. McGrail, Elizabeth M. Whitley, Rosemarie E. Schmandt, Xiaoping Su, Nisha Gokul, Karen H. Lu, Emily Hinchcliff, Melinda S. Yates, Brenda Melendez
Publikováno v:
Clinical Cancer Research. 27:PR008-PR008
Introduction: Microsatellite instability (MSI), caused by defects in DNA mismatch repair genes, including MLH1 and MSH2, occur in 30% of endometrial cancers (EC). High mutational loads associated with MSI have been associated with greater immunogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3dea0d1bdbb2cdf5e043047eddd7137
https://doi.org/10.1158/1557-3265.endomet20-pr008
https://doi.org/10.1158/1557-3265.endomet20-pr008
Autor:
Elizabeth M. Whitley, Rosemarie E. Schmandt, Brenda Melendez, Emily Hinchcliff, Karen H. Lu, Nisha Gokul, Russell Broaddus, Melinda S. Yates
Publikováno v:
Cancer Research. 80:3421-3421
Inherited or sporadic defects in mismatch repair genes (MLH1, MSH2, MSH6, and PSM2) can lead to microsatellite instable (MSI) tumors, most commonly colon, endometrial or gastric tumors. High mutation rates in MSI tumors have been associated with grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4ddfce2ee5bcb17d3698a537bda8e54
https://doi.org/10.1158/1538-7445.am2020-3421
https://doi.org/10.1158/1538-7445.am2020-3421
Autor:
Nisha Gokul, Nadéra Mansouri-Attia, Swamy K. Tripurani, Hermann Piard, Stephanie A. Pangas, Matthew L. Anderson, Karen W. Eldin
Publikováno v:
Molecular Endocrinology. 28:1887-1898
Molecular changes that give rise to granulosa cell tumors of the ovary are not well understood. Previously, we showed that deletion in granulosa cells of the bone morphogenetic protein receptor-signaling transcription factors, Smad1 and Smad5, causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b448a22826d5d05c0e804ce13cb8e6e
https://doi.org/10.1210/me.2014-1217
https://doi.org/10.1210/me.2014-1217
Autor:
Monique Monita, Eric Boerwinkle, Stacy M. Herring, Nisha Gokul, Rebecca Bell, Peter A. Doris, Megan L. Grove
Publikováno v:
Circulation: Cardiovascular Genetics. 4:223-231
Background— The recent development of a large panel of genome-wide single nucleotide polymorphisms (SNPs) provides the opportunity to examine genetic relationships between distinct SHR lines that share hypertension but differ in their susceptibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecf32ad4f03161a01a256fc571b13af
https://doi.org/10.1161/circgenetics.110.958934
https://doi.org/10.1161/circgenetics.110.958934
Autor:
Nisha Gokul, Yaming Zhu, Scott E. Wenderfer, Peter A. Doris, Stacy M. Herring, Manuel L. Gonzalez-Garay, Rebecca Bell, Michael C. Braun, Monique Monita
Background— The spontaneously hypertensive rat (SHR) strain exists in lines that contrast strongly in susceptibility to renal injury in hypertension. These inbred lines share common ancestry, and only 13% of their genomes arise from different ances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44226abd05113b54d7b1f144e3bfc19f
https://europepmc.org/articles/PMC4270933/
https://europepmc.org/articles/PMC4270933/
Autor:
Rebecca Bell, M. John Hicks, Stacy M. Herring, Monique Monita, Scott E. Wenderfer, Michael C. Braun, Peter A. Doris, Nisha Gokul
Publikováno v:
Journal of hypertension. 31(10)
Spontaneously hypertensive rat (SHR) lines differ in their susceptibility to hypertensive end-organ disease and may provide an informative model of genetic risk of disease. Lines derived from the original SHR-B and SHR-C clades are highly resistant t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2895f7ee8e663bb3fd19a81435977c8
https://pubmed.ncbi.nlm.nih.gov/24107734
https://pubmed.ncbi.nlm.nih.gov/24107734
Autor:
Peter A. Doris, Nisha Gokul, Michael C. Braun, Monique Monita, Eric Boerwinkle, Rebecca Bell, Scott E. Wenderfer, Stacy M. Herring
Publikováno v:
Journal of the American Society of Nephrology : JASN. 22(5)
The interaction between IgG and Fc-γ receptors in glomeruli contributes to the development of several types of proteinuric glomerular disease, but the involvement of immunological mechanisms in hypertensive renal injury is incompletely understood. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44253194628795fc7452b8769a49d500
https://pubmed.ncbi.nlm.nih.gov/21454716
https://pubmed.ncbi.nlm.nih.gov/21454716