Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

Autor: Ryan S D'Souza, Jun Y Lim, Alper Turgut, Kelly Servage, Junmei Zhang, Kim Orth, Nisha G Sosale, Matthew J Lazzara, Jeremy Allegood, James E Casanova

Publikováno v: eLife, Vol 9 (2020)

Coordinated assembly and disassembly of integrin-mediated focal adhesions (FAs) is essential for cell migration. Many studies have shown that FA disassembly requires Ca2+ influx, however our understanding of this process remains incomplete. Here, we

Externí odkaz: https://doaj.org/article/ccb351f40ae24823b1c3f79d2970f156

CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer

Autor: Danielle C. Llaneza, Matthew J. Lazzara, Nisha G. Sosale, Robert Cornelison, Charles N. Landen, Alexandra R. Harris, Kuntal Biswas

Publikováno v: Cancers, Vol 13, Iss 5056, p 5056 (2021)
Cancers
Volume 13
Issue 20

Epithelial ovarian cancer (EOC) is the deadliest of the gynecologic malignancies, with an overall survival rate of <
30%. Recent research has suggested that targeting RNA polymerase I (POL I) with small-molecule inhibitors may be a viable ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0331dc90657b4ad6a680e542d0545a51
https://doi.org/10.3390/cancers13205056

Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

Autor: Aizhen Xiao, Nisha G. Sosale, Evan K. Day, Qing Zhong, Benjamin Purow, Matthew J. Lazzara

Publikováno v: Cell Rep
Cell Reports, Vol 30, Iss 10, Pp 3383-3396.e7 (2020)

Summary: SPRY2 is a purported tumor suppressor in certain cancers that promotes tumor growth and resistance to receptor tyrosine kinase inhibitors in glioblastoma. Here, we identify a SPRY2-dependent bypass signaling mechanism in glioblastoma that dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a84b12effdd7a4b5fae979782fb3d84
https://pubmed.ncbi.nlm.nih.gov/32160544

'Marker of Self' CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors

Autor: Jake Hsu, Richard K. Tsai, Joe Swift, Irena I. Ivanovska, Dennis E. Discher, Nisha G. Sosale, Cory Alvey, Philip W. Zoltick

Publikováno v: Sosale, N G, Ivanovska, I, Tsai, R K, Swift, J, Hsu, J W, Alvey, C M, Zoltick, P W & Discher, D E 2016, ' "Marker of Self" CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors ', Molecular Therapy-Methods & Clinical Development . https://doi.org/10.1038/mtm.2016.80
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development

Lentiviruses infect many cell types and are now widely used for gene delivery in vitro, but in vivo uptake of these foreign vectors by macrophages is a limitation. Lentivectors are produced here from packaging cells that overexpress “Marker of Self

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deefb76771c9db6faae26cb3c80d0fca
https://doi.org/10.1038/mtm.2016.80

Cell rigidity and shape override CD47’s 'self'-signaling in phagocytosis by hyperactivating myosin-II

Autor: Nisha G. Sosale, Rumiana Dimova, Dennis E. Discher, Andrew Bradshaw, Reinhard Lipowsky, Tahereh Rouhiparkouhi

A macrophage engulfs another cell or foreign particle in an adhesive process that often activates myosin-II, unless the macrophage also engages “marker of self” CD47 that inhibits myosin. For many cell types, adhesion-induced activation of myosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc0bf7ad96eb426ab8522e9b76bcd78
https://europepmc.org/articles/PMC4296014/