Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nisha A. Cavanaugh"'
Autor:
William A. Beard, Vinod K. Batra, Nisha A. Cavanaugh, David D. Shock, Michael J. Howard, Samuel H. Wilson
Publikováno v:
J Biol Chem
DNA polymerase β has two DNA-binding domains that interact with the opposite sides of short DNA gaps. These domains contribute two activities that modify the 5' and 3' margins of gapped DNA during base excision repair. DNA gaps greater than 1 nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0d86b0e11f91053f7d932430f16540
https://pubmed.ncbi.nlm.nih.gov/31801827
https://pubmed.ncbi.nlm.nih.gov/31801827
Autor:
Mary Alexander, Adriana Bankston, Fabian Cannizzo, Montserrat Castelló, Nisha A. Cavanaugh, Bennett B. Goldberg, Karen J. Haley, Sarah C. Hokanson, Karri Holley, Tara D. Hudson, Audrey J. Jaeger, Aliya Kuzhabekova, Christian Mauri, Lynn McAlpine, Gary S. McDowell, Keith Micoli, Nick Osbaldiston, Kirsi Pyhältö, Shan Simmonds, Xuhong Su, Christine Teelken, Inge van der Weijden, Steve Wendell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a2e60a037d5bad20059923543736d73
https://doi.org/10.1016/b978-0-12-813169-5.01002-8
https://doi.org/10.1016/b978-0-12-813169-5.01002-8
Autor:
William A. Beard, Thomas W. Kirby, Samuel H. Wilson, David D. Shock, Geoffrey A. Mueller, Eugene F. DeRose, Nisha A. Cavanaugh, Robert E. London
Publikováno v:
Nucleic Acids Research
Binding of the catalytic divalent ion to the ternary DNA polymerase β/gapped DNA/dNTP complex is thought to represent the final step in the assembly of the catalytic complex and is consequently a critical determinant of replicative fidelity. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddd60ea5f4260e736dfd280204a2e4f
http://europepmc.org/articles/PMC3326329
http://europepmc.org/articles/PMC3326329
Publikováno v:
Journal of Biological Chemistry. 285:24457-24465
DNA polymerases must select nucleotides that preserve Watson-Crick base pairing rules and choose substrates with the correct (deoxyribose) sugar. Sugar discrimination represents a great challenge because ribonucleotide triphosphates are present at mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1192294bc1ca9227ae7935049917b6a
https://doi.org/10.1074/jbc.m110.132407
https://doi.org/10.1074/jbc.m110.132407
Publikováno v:
Biochemistry. 48:10199-10207
The helicase-primase complex from herpes simplex virus-1 contains three subunits, UL5, UL52, and UL8. We generated each of the potential two-subunit complexes, UL5-UL52, UL5-UL8, and UL52-UL8, and used a series of kinetic and photo-cross-linking stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae52bbed2a4755c38c021a94ef5dc6e5
https://doi.org/10.1021/bi9010144
https://doi.org/10.1021/bi9010144
Autor:
Robert D. Kuchta, Nisha A. Cavanaugh
Publikováno v:
Journal of Biological Chemistry. 284:1523-1532
A key set of reactions for the initiation of new DNA strands during herpes simplex virus-1 replication consists of the primase-catalyzed synthesis of short RNA primers followed by polymerase-catalyzed DNA synthesis (i.e. primase-coupled polymerase ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4448c484f2fe40d5501d6db8fb8648
https://doi.org/10.1074/jbc.m805476200
https://doi.org/10.1074/jbc.m805476200
Autor:
Nicolas Joubert, Travis J. Lund, Jennifer N. Patro, Michal Hocek, Robert D. Kuchta, Milan Urban, Nisha A. Cavanaugh
Accurate replication of genomic DNA is critical for cellular survival and proliferation. Despite the complexity of the cellular DNA replication process, the overall error rates are remarkably low. Three discrete processes contribute to the accuracy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52b1ee8b031f0a4fa788e8072212062
https://europepmc.org/articles/PMC3156867/
https://europepmc.org/articles/PMC3156867/
Autor:
Lee G. Pedersen, Vinod K. Batra, William A. Beard, Samuel H. Wilson, Nisha A. Cavanaugh, Lalith Perera
DNA polymerases can misinsert ribonucleotides that lead to genomic instability. DNA polymerase β discourages ribonucleotide insertion with the backbone carbonyl of Tyr-271; alanine substitution of Tyr-271, but not Phe-272, resulted in a >10-fold los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b2e01b1ffa2b527e0af3a77bd63a71
https://europepmc.org/articles/PMC3173102/
https://europepmc.org/articles/PMC3173102/
Publikováno v:
The Journal of biological chemistry. 285(32)
DNA polymerases must select nucleotides that preserve Watson-Crick base pairing rules and choose substrates with the correct (deoxyribose) sugar. Sugar discrimination represents a great challenge because ribonucleotide triphosphates are present at mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77f4c893f0c65fe2ea7197253d74cf27
https://pubmed.ncbi.nlm.nih.gov/20519499
https://pubmed.ncbi.nlm.nih.gov/20519499
To accurately replicate its viral genome, the Herpes Simplex Virus 1 (HSV-1) DNA polymerase usually polymerizes the correct natural 2'-deoxy-5'-triphosphate (dNTP) opposite the template base being replicated. We employed a series of purine-dNTP analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bba8638f9f3be6b511c71b75ad8e0c
https://europepmc.org/articles/PMC2670348/
https://europepmc.org/articles/PMC2670348/