Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Nisha, Padmanabhan"'
Autor:
Taotao Sheng, Shamaine Wei Ting Ho, Wen Fong Ooi, Chang Xu, Manjie Xing, Nisha Padmanabhan, Kie Kyon Huang, Lijia Ma, Mohana Ray, Yu Amanda Guo, Ngak Leng Sim, Chukwuemeka George Anene-Nzelu, Mei Mei Chang, Milad Razavi-Mohseni, Michael A. Beer, Roger Sik Yin Foo, Raghav Sundar, Yiong Huak Chan, Angie Lay Keng Tan, Xuewen Ong, Anders Jacobsen Skanderup, Kevin P. White, Sudhakar Jha, Patrick Tan
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-25 (2021)
Abstract Background Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity—however, most p
Externí odkaz:
https://doaj.org/article/38cedd9ca8014168bc07ffb9aa64af83
Autor:
Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-O K Lee, Vineeth T. Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J. Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A. Luftig, Dennis Kappei, Warren D. Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen, Patrick Tan
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype, observed in multiple malignancies and associated with the epigenetic silencing of tumor suppressors. Currently, for most cancers including gastric cancer (
Externí odkaz:
https://doaj.org/article/9fe03d39024a4581867a3f4455dc22c4
Autor:
Kie Kyon Huang, Jiawen Huang, Jeanie Kar Leng Wu, Minghui Lee, Su Ting Tay, Vikrant Kumar, Kalpana Ramnarayanan, Nisha Padmanabhan, Chang Xu, Angie Lay Keng Tan, Charlene Chan, Dennis Kappei, Jonathan Göke, Patrick Tan
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background Deregulated gene expression is a hallmark of cancer; however, most studies to date have analyzed short-read RNA sequencing data with inherent limitations. Here, we combine PacBio long-read isoform sequencing (Iso-Seq) and Illumina
Externí odkaz:
https://doaj.org/article/3769f999db7f45c5ba41d9dc617249e6
Autor:
Alice P. Sowton, Nisha Padmanabhan, Simon J. Tunster, Ben D. McNally, Antonio Murgia, Aisha Yusuf, Julian L. Griffin, Andrew J. Murray, Erica D. Watson
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 23, Iss , Pp - (2020)
Nonalcoholic fatty liver disease (NAFLD) is associated with dietary folate deficiency and mutations in genes required for one‑carbon metabolism. However, the mechanism through which this occurs is unclear. To improve our understanding of this link,
Externí odkaz:
https://doaj.org/article/b828d8c6f0654a398e8fa0e34097c012
Autor:
Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-Ok Lee, Vineeth T. Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J. Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A. Luftig, Dennis Kappei, Warren D. Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen, Patrick Tan
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/a15ba86b39964ee19473ec85a8dc3eb7
Autor:
Patrick Tan, Jimmy Bok Yan So, Wei Peng Yong, Ming Teh, Huey Yew Jeffrey Lum, Kong-Peng Lam, Shengli Xu, Biyan Zhang, Qingfeng Chen, Asim Shabbir, Guowei Kim, Takatsugu Ishimoto, Angie Lay Keng Tan, Shamaine Wei Ting Ho, Su Ting Tay, Kie Kyon Huang, Vivien Koh, Tadahito Yasuda, Mayu Koiwa, Supriya Srivastava, Nisha Padmanabhan, Raghav Sundar, Kalpana Ramnarayanan, Vikrant Kumar
Gastric cancer heterogeneity represents a barrier to disease management. We generated a comprehensive single-cell atlas of gastric cancer (>200,000 cells) comprising 48 samples from 31 patients across clinical stages and histologic subtypes. We ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933ffc56e0e6a3c0e3446453cd9e102e
https://doi.org/10.1158/2159-8290.c.6549613.v1
https://doi.org/10.1158/2159-8290.c.6549613.v1
Autor:
Patrick Tan, Jimmy Bok Yan So, Wei Peng Yong, Ming Teh, Huey Yew Jeffrey Lum, Kong-Peng Lam, Shengli Xu, Biyan Zhang, Qingfeng Chen, Asim Shabbir, Guowei Kim, Takatsugu Ishimoto, Angie Lay Keng Tan, Shamaine Wei Ting Ho, Su Ting Tay, Kie Kyon Huang, Vivien Koh, Tadahito Yasuda, Mayu Koiwa, Supriya Srivastava, Nisha Padmanabhan, Raghav Sundar, Kalpana Ramnarayanan, Vikrant Kumar
Supplementary Data from Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c138bf982558607d1cdca0dea4a776
https://doi.org/10.1158/2159-8290.22541323.v1
https://doi.org/10.1158/2159-8290.22541323.v1
Autor:
Patrick Tan, Bin Tean Teh, Chawalit Pairojkul, Tatsuhiro Shibata, Steven G. Rozen, Raluca Gordân, Ludmil B. Alexandrov, Young Nyun Park, Hyungjin Rhee, André Luiz Vettore, André Lopes Carvalho, Di-Xian Luo, Jiaming Lai, Aldo Scarpa, Ming-Chin Yu, Sen-Yung Hsieh, Philippe Broet, Irinel Popescu, Dan G. Duda, Simona Dima, Kiat Hon Lim, London Lucien Peng Jin Ooi, Alexander Yaw Fui Chung, Pierce Kah-Hoe Chow, Satoshi Yamasaki, Yasuhito Arai, Hiromi Nakamura, Yasushi Totoki, Sopit Wongkham, Puangrat Yongvanit, Vajaraphongsa Bhudhisawasdi, Narong Khuntikeo, John R. McPherson, Jia Liang Loh, Jing Tan, Tse Hui Lim, Alvin Soon Tiong Lim, Stefanus Lie, Vikneswari Rajasegaran, Choon Kiat Ong, Mo Liu, Arnoud Boot, Cedric Chuan Young Ng, Weng Khong Lim, Sanjanaa Nagarajan, Raynoo Thanan, Swe Swe Myint, Su Pin Choo, Ley Moy Ng, Alvin Wei Tian Ng, Sarinya Kongpetch, Vishwa Nellore, Nisha Padmanabhan, Mi Ni Huang, Jing Quan Lim, Chern Han Yong, Ioana Cutcutache, Apinya Jusakul
Summary of Patients and Clinical Data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31eb3f353835bcfd1c8a3cf3c52e2f9d
https://doi.org/10.1158/2159-8290.22532000.v1
https://doi.org/10.1158/2159-8290.22532000.v1
Autor:
Patrick Tan, Bin Tean Teh, Chawalit Pairojkul, Tatsuhiro Shibata, Steven G. Rozen, Raluca Gordân, Ludmil B. Alexandrov, Young Nyun Park, Hyungjin Rhee, André Luiz Vettore, André Lopes Carvalho, Di-Xian Luo, Jiaming Lai, Aldo Scarpa, Ming-Chin Yu, Sen-Yung Hsieh, Philippe Broet, Irinel Popescu, Dan G. Duda, Simona Dima, Kiat Hon Lim, London Lucien Peng Jin Ooi, Alexander Yaw Fui Chung, Pierce Kah-Hoe Chow, Satoshi Yamasaki, Yasuhito Arai, Hiromi Nakamura, Yasushi Totoki, Sopit Wongkham, Puangrat Yongvanit, Vajaraphongsa Bhudhisawasdi, Narong Khuntikeo, John R. McPherson, Jia Liang Loh, Jing Tan, Tse Hui Lim, Alvin Soon Tiong Lim, Stefanus Lie, Vikneswari Rajasegaran, Choon Kiat Ong, Mo Liu, Arnoud Boot, Cedric Chuan Young Ng, Weng Khong Lim, Sanjanaa Nagarajan, Raynoo Thanan, Swe Swe Myint, Su Pin Choo, Ley Moy Ng, Alvin Wei Tian Ng, Sarinya Kongpetch, Vishwa Nellore, Nisha Padmanabhan, Mi Ni Huang, Jing Quan Lim, Chern Han Yong, Ioana Cutcutache, Apinya Jusakul
Supplementary Figure 1. Unsupervised Clustering on CCA samples. Supplementary Figure 2. Alterations Found in CCA Clusters. Supplementary Figure 3. MAP2K4 Homozygous Deletions and ERBB2 Amplifications. Supplementary Figure 4. Alterations Related to St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b64d72f5acb72a6b0f7f7ad8dac7ea0
https://doi.org/10.1158/2159-8290.22532006.v1
https://doi.org/10.1158/2159-8290.22532006.v1
Autor:
Patrick Tan, Bin Tean Teh, Chawalit Pairojkul, Tatsuhiro Shibata, Steven G. Rozen, Raluca Gordân, Ludmil B. Alexandrov, Young Nyun Park, Hyungjin Rhee, André Luiz Vettore, André Lopes Carvalho, Di-Xian Luo, Jiaming Lai, Aldo Scarpa, Ming-Chin Yu, Sen-Yung Hsieh, Philippe Broet, Irinel Popescu, Dan G. Duda, Simona Dima, Kiat Hon Lim, London Lucien Peng Jin Ooi, Alexander Yaw Fui Chung, Pierce Kah-Hoe Chow, Satoshi Yamasaki, Yasuhito Arai, Hiromi Nakamura, Yasushi Totoki, Sopit Wongkham, Puangrat Yongvanit, Vajaraphongsa Bhudhisawasdi, Narong Khuntikeo, John R. McPherson, Jia Liang Loh, Jing Tan, Tse Hui Lim, Alvin Soon Tiong Lim, Stefanus Lie, Vikneswari Rajasegaran, Choon Kiat Ong, Mo Liu, Arnoud Boot, Cedric Chuan Young Ng, Weng Khong Lim, Sanjanaa Nagarajan, Raynoo Thanan, Swe Swe Myint, Su Pin Choo, Ley Moy Ng, Alvin Wei Tian Ng, Sarinya Kongpetch, Vishwa Nellore, Nisha Padmanabhan, Mi Ni Huang, Jing Quan Lim, Chern Han Yong, Ioana Cutcutache, Apinya Jusakul
Structural Variations across 71 WGS CCAs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f33883e0358096b689b53a975afae90
https://doi.org/10.1158/2159-8290.22531985
https://doi.org/10.1158/2159-8290.22531985