Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nischay Rege"'
Autor:
Pamela Itkin-Ansari, Peter Arvan, Nalinda P. Wickramasinghe, Saiful A. Mir, Arfah Anjum, Michael A. Weiss, Xin Li, Leena Haataja, Yi Xiong, Nischay Rege, Li Lv, Wei Chen, David A. Ostrov, Randal J. Kaufman, Balamurugan Dhayalan, Rachel Madley, Dennis Larkin, Ming Liu, Jinhong Sun
Publikováno v:
Diabetes. 69:954-964
Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin (PI) in the endoplasmic reticulum (ER) drive the molecular pathogenesis of mutant INS gene–induced diabetes of youth (MIDY). How these abnormal interactions are initiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2e6fa1101a6b91c5b06ef2264636ac
https://doi.org/10.2337/db19-1106
https://doi.org/10.2337/db19-1106
Autor:
Peter Arvan, Nischay Rege, Anoop Arunagiri, Jinhong Sun, Randal J. Kaufman, Jing Yong, Michael A. Weiss, Ming Liu, Leena Haataja
Publikováno v:
Diabetes, Obesity and Metabolism. 20:28-50
Insulin synthesis in pancreatic β-cells is initiated as preproinsulin. Prevailing glucose concentrations, which oscillate pre- and postprandially, exert major dynamic variation in preproinsulin biosynthesis. Accompanying upregulated translation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7132a9dfb4cbe41cff2d79bc9cee8a29
https://doi.org/10.1111/dom.13378
https://doi.org/10.1111/dom.13378
Autor:
Michael A. Weiss, Nischay Rege, Nalinda P. Wickramasinghe, Faramarz Ismail-Beigi, Alisar N. Tustan, Vivien C. Yee, Nelson B. Phillips
Publikováno v:
Journal of Biological Chemistry. 293:10895-10910
Key contributions to protein structure and stability are provided by weakly polar interactions, which arise from asymmetric electronic distributions within amino acids and peptide bonds. Of particular interest are aromatic side chains whose direction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1920c66b3e553caf1ac3c0983e89c908
https://doi.org/10.1074/jbc.ra118.003650
https://doi.org/10.1074/jbc.ra118.003650
Autor:
Jinhong, Sun, Yi, Xiong, Xin, Li, Leena, Haataja, Wei, Chen, Saiful A, Mir, Li, Lv, Rachel, Madley, Dennis, Larkin, Arfah, Anjum, Balamurugan, Dhayalan, Nischay, Rege, Nalinda P, Wickramasinghe, Michael A, Weiss, Pamela, Itkin-Ansari, Randal J, Kaufman, David A, Ostrov, Peter, Arvan, Ming, Liu
Publikováno v:
Diabetes
Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin (PI) in the endoplasmic reticulum (ER) drive the molecular pathogenesis of mutant INS gene–induced diabetes of youth (MIDY). How these abnormal interactions are initiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0655fd6cab56bca04ffbdb08a0fc1836
https://pubmed.ncbi.nlm.nih.gov/32139596
https://pubmed.ncbi.nlm.nih.gov/32139596
Autor:
Saiful A. Mir, Michael A. Weiss, Randal J. Kaufman, Peter Arvan, Arfah Anjum, David A. Ostrov, Balamurugan Dhayalan, Yi Xiong, Pamela Itkin-Ansari, Wei Chen, Rachel Madley, Xin Li, Nischay Rege, Jinhong Sun, Dennis Larkin, Nalinda P. Wickramasinghe, Leena Haataja, Ming Liu
Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin in the endoplasmic reticulum (ER) drive the molecular pathogenesis of Mutant-INS-gene induced Diabetes of Youth (MIDY). How these abnormal interactions are initiated remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d4c1addac9176e86a1d13a444b185d
Autor:
Michael C. Lawrence, Manijeh Phillips, Nalinda P. Wickramasinghe, Faramarz Ismail-Beigi, Nelson B. Phillips, Jonathan Whittaker, Kelley Carr, Michael D. Glidden, Yanwu Yang, Khadijah Aldabbagh, Nischay Rege, Yen Shan Chen, Michael A. Weiss, Mamuni Swain, Yi Peng, Vivien C. Yee
Thermal degradation of insulin complicates its delivery and use. Previous efforts to engineer ultra-stable analogs were confounded by prolonged cellular signaling in vivo, of unclear safety and complicating mealtime therapy. We therefore sought an ul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f08dc8ce4ba088ce3c8e664fec15372
https://europepmc.org/articles/PMC5766902/
https://europepmc.org/articles/PMC5766902/
Autor:
Orit Weil‐Ktorza, Nischay Rege, Shifra Lansky, Deborah E. Shalev, Gil Shoham, Michael A. Weiss, Norman Metanis
Publikováno v:
Chemistry – A European Journal. 25:8430-8430
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21c0dbc8a5e9d4da465c186ba721fa86
https://doi.org/10.1002/chem.201901974
https://doi.org/10.1002/chem.201901974