Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Nis, Halland"'
Autor:
Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, Nis Halland, Kaihui Hu He, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang, Nieng Yan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Human glucose transporters (GLUTs), particularly GLUT1 and GLUT3, are potential anticancer therapy targets. Here, Nan Wang et al. use an engineered GLUT 3 variant to identify an exofacial GLUT3 inhibitor, SA47, and elucidate the drug’s inhibitory m
Externí odkaz:
https://doaj.org/article/838595b279b94ca5b2244bbb0e9ea054
Autor:
Yannis Hara, Viktor T. Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, Samuel Lessard, Alexandra Hicks, David R. Light
Publikováno v:
Blood Advances. 7:2317-2323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b730d75d1f067b3b3c4a1287202013
https://doi.org/10.1182/bloodadvances.2022008710
https://doi.org/10.1182/bloodadvances.2022008710
Autor:
María P. López-Alberca, Rana Alsalim, Marc Nazaré, Sandra Miksche, Werngard Czechtizky, Peter Lindemann, Nis Halland
Publikováno v:
Organic Letters. 22:7393-7396
The development of a novel selective synthesis of 3-amino-2H-indazoles from readily available 2-halobenzonitriles is presented. The reaction proceeds through a domino reaction sequence, consisting of a regioselective palladium-catalyzed coupling of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2731b8b5e01b5fbb7321f900252a0a74
https://doi.org/10.1021/acs.orglett.0c02766
https://doi.org/10.1021/acs.orglett.0c02766
Autor:
Nis Halland, Friedemann Schmidt, Tilo Weiss, Ziyu Li, Jörg Czech, Joachim Saas, Danping Ding-Pfennigdorff, Matthias K. Dreyer, Carsten Strübing, Marc Nazare
Publikováno v:
Journal of medicinal chemistry. 65(2)
The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. Today, no oral disease-modifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0ee7976823a8fb6cc8f2ac1ed92537
https://pubmed.ncbi.nlm.nih.gov/34931844
https://pubmed.ncbi.nlm.nih.gov/34931844
Autor:
Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, Nis Halland, Kaihui Hu He, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang, Nieng Yan
Publikováno v:
Nature communications. 13(1)
Human glucose transporters (GLUTs) are responsible for cellular uptake of hexoses. Elevated expression of GLUTs, particularly GLUT1 and GLUT3, is required to fuel the hyperproliferation of cancer cells, making GLUT inhibitors potential anticancer the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cf0f8ec33788632d037a0b888d3098
https://pubmed.ncbi.nlm.nih.gov/35552392
https://pubmed.ncbi.nlm.nih.gov/35552392
Autor:
Rana, Alsalim, Peter, Lindemann, María Pascual, López-Alberca, Sandra, Miksche, Werngard, Czechtizky, Nis, Halland, Marc, Nazaré
Publikováno v:
Organic letters. 22(18)
The development of a novel selective synthesis of 3-amino-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::438fb3b6b3483e85feaab41e12493f0e
https://pubmed.ncbi.nlm.nih.gov/32870012
https://pubmed.ncbi.nlm.nih.gov/32870012
Publikováno v:
Blood. 138:963-963
Introduction: Novel and safe therapeutic targets to increase expression of fetal hemoglobin (HbF) have potential to treat b-hemoglobinopathies (Platt, Brambilla et al. 1994, Steinberg 2020), including sickle cell disease (SCD) in which red blood cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65183020f63f63e626826998a27c80ac
https://doi.org/10.1182/blood-2021-146071
https://doi.org/10.1182/blood-2021-146071
Publikováno v:
Chemical research in toxicology. 32(11)
One of the most appreciated capabilities of computational toxicology is to support the design of pharmaceuticals with reduced toxicological hazard. To this end, we have strengthened our drug photosafety assessments by applying novel computer models f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9fa03bc6048f3d68d2102dac7290db
https://pubmed.ncbi.nlm.nih.gov/31625387
https://pubmed.ncbi.nlm.nih.gov/31625387
Autor:
Markus Kohlmann, Werngard Czechtizky, Jörg Czech, Andreas Evers, Markus Follmann, Herman Schreuder, Christopher Kallus, Nis Halland
Publikováno v:
Journal of Medicinal Chemistry. 59:9567-9573
Previously disclosed TAFIa inhibitors having a urea zinc-binding motif were used as the starting point for the development of a novel class of highly potent inhibitors having a sulfamide zinc-binding motif. High-resolution X-ray cocrystal structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7411f50d0e65cf500ed64838d3c5009
https://doi.org/10.1021/acs.jmedchem.6b01276
https://doi.org/10.1021/acs.jmedchem.6b01276
Publikováno v:
Journal of Medicinal Chemistry. 59:3579-3592
In this Perspective, recent advances and challenges in the development of GPR119 agonists as new oral antidiabetic drugs will be discussed. Such agonists are expected to exhibit a low risk to induce hypoglycemia as well as to have a beneficial impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684667b796a03b2f75d9d8ba8cb47dd4
https://doi.org/10.1021/acs.jmedchem.5b01198
https://doi.org/10.1021/acs.jmedchem.5b01198