Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nirupama B. Soni"'
Autor:
Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. Modification of the isoindoline and/or the terminal func
Autor:
Lisa A. Hasvold, Steven W. Elmore, Nirupama B. Soni, Leiming Li, Yu Shen, George S. Sheppard, Terrance J. Magoc, Carol K. Wada, Dachun Liu, Sanjay C. Panchal, Scott E. Warder, Chaohong Sun, Keith F. McDaniel, Lauren Smithee, Xiaoyu Lin, Daniel H. Albert, Xiaoli Huang, Chang H. Park, Le Wang, Peter Kovar, F. Greg Buchanan, Warren M. Kati, Robert A. Mantei, Robbert Hubbard, Andrew M. Petros, Steven D. Fidanze, Denise Wilcox, John K. Pratt
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(10)
An NMR fragment screen for binders to the bromodomains of BRD4 identified 2-methyl-3-ketopyrroles 1 and 2. Elaboration of these fragments guided by structure-based design provided lead molecules with significant activity in a mouse tumor model. Furth
Autor:
Philip J. Merta, Amanda M. Olson, Fritz G. Buchanan, Nirupama B. Soni, Donald J. Osterling, Alan S. Florjancic, Debra Ferguson, David Maag, Eric F. Johnson, Yunsong Tong, Alexander R. Shoemaker, Maricel Torrent, Kenneth D. Bromberg, Thomas D. Penning, Loren M. Lasko
Publikováno v:
ACS Medicinal Chemistry Letters. 6:58-62
Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure-activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for b
Autor:
Kerren K. Swinger, Magdalena Przytulinska, Yunsong Tong, Alan S. Florjancic, Eric F. Johnson, Philip J. Merta, Kent D. Stewart, Thomas D. Penning, Nirupama B. Soni, Alexander R. Shoemaker, John E. Harlan, Haizhong Zhu
Publikováno v:
ACS Medicinal Chemistry Letters. 4:211-215
To investigate the role played by the unique pre-DFG residue Val 195 of Cdc7 kinase on the potency of azaindole-chloropyridines (1), a series of novel analogues with various chloro replacements were synthesized and evaluated for their inhibitory acti
Autor:
Mai-Ha Bui, Nirupama B. Soni, Jennifer B. Donnelly, Eric F. Johnson, Keith B. Glaser, Zehan Chen, Sujatha M. Gopalakrishnan, Usha Warrior
Publikováno v:
Journal of Biological Chemistry. 286:43951-43958
Eukaryotic elongation factor-2 kinase (eEF2K) relays growth and stress signals to protein synthesis through phosphorylation and inactivation of eukaryotic elongation factor 2 (eEF2). 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) is a widely acc
Autor:
Xuesong Liu, Vincent L. Giranda, Luis E. Rodriguez, Paul A. Ellis, Donald J. Osterling, Magdalena Przytulinska, David Frost, Thomas D. Penning, Jason Stavropoulos, Cherrie K. Donawho, Yunsong Tong, Eric F. Johnson, Joel D. Leverson, Jennifer J. Bouska, Yan Shi, Patrick A. Marcotte, Amanda M. Olson, Sheela A. Thomas, Nirupama B. Soni, Yan Luo
Publikováno v:
Journal of Medicinal Chemistry. 52:6803-6813
Small molecule inhibitors of PARP-1 have been pursued by various organizations as potential therapeutic agents either capable of sensitizing cytotoxic treatments or acting as stand-alone agents to combat cancer. As one of the strategies to expand our
Autor:
Kent D. Stewart, Saul H. Rosenberg, Thomas D. Penning, Zhi-Fu Tao, Vincent S Giranda, Lisa A. Hasvold, Jennifer J. Bouska, Thomas J. Sowin, Eric F. Johnson, Joel D. Leverson, Vincent S. Stoll, Edward K. Han, Geoff Stamper, Nan-Horng Lin, Ran Guan, Nirupama B. Soni, Yan Luo
Publikováno v:
Journal of Medicinal Chemistry. 52:6621-6636
Pim-1, Pim-2, and Pim-3 are a family of serine/threonine kinases which have been found to be overexpressed in a variety of hematopoietic malignancies and solid tumors. Benzothienopyrimidinones were discovered as a novel class of Pim inhibitors that p
Autor:
Bailin Shaw, David Maag, Clarissa G. Jakob, Zhi Wang, Gary G. Chiang, Peter Brown, Fengling Li, Nirupama B. Soni, Mikkel Algire, Steven Kennedy, Jun Guo, Masoud Vedadi, Cheryl H. Arrowsmith, William N. Pappano, Ramzi F. Sweis
A lack of useful small molecule tools has precluded thorough interrogation of the biological function of SMYD2, a lysine methyltransferase with known tumor-suppressor substrates. Systematic exploration of the structure–activity relationships of a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230cd6a551a6ef053ea9ced96756b5c3
https://europepmc.org/articles/PMC4468393/
https://europepmc.org/articles/PMC4468393/
Autor:
Gary G. Chiang, Masoud Vedadi, Michael R. Michaelides, William N. Pappano, Nirupama B. Soni, Jun Guo, David Maag, Andrew M. Petros, Chris Tse, Fengling Li, Marina A. Pliushchev, Ramzi F. Sweis, Peter Brown
Publikováno v:
ACS medicinal chemistry letters. 5(2)
G9a is a histone lysine methyltransferase responsible for the methylation of histone H3 lysine 9. The discovery of A-366 arose from a unique diversity screening hit, which was optimized by incorporation of a propyl-pyrrolidine subunit to occupy the e
Autor:
Yujia Dai, Cele Abad-Zapatero, Steve K. Davidsen, Kent D. Stewart, Ru-Qi Wei, Keith B. Glaser, Zhiqin Ji, Nirupama B. Soni, Terry Magoc, Michael R. Michaelides, Jennifer J. Bouska, Daniel H. Albert, Patrick A. Marcotte
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
Four hinge-binding scaffolds have been explored for novel selective Aurora kinase inhibitors. The structure activity relationship, selectivity and pharmacokinetic profiles have been evaluated.