Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Niru B. Soni"'
Autor:
Gary G. Chiang, Masoud Vedadi, Alberto Martin, Dalia Barsyte-Lovejoy, William N. Pappano, Cheryl H. Arrowsmith, Alexander Nuber, Vijayaratnam Santhakumar, Kenneth M. Comess, Judd C. Rice, Maricel Torrent, Gunnar Schotta, Peter Brown, Conglei Li, Anup K. Upadhyay, Fengling Li, Alex R Shoemaker, Ramzi F. Sweis, Mikkel Algire, Yujia Dai, Loren M. Lasko, Taylor R H Mitchell, Creighton T. Tuzon, Kenneth D. Bromberg, Mohammad S. Eram, Michael R. Michaelides, Niru B. Soni, Clarissa G. Jakob, Chaohong Sun, Manisha A Jhala, Vlasios Manaves
Publikováno v:
Nature Chemical Biology. 13:317-324
Protein lysine methyltransferases (PKMTs) regulate diverse physiological processes including transcription and the maintenance of genomic integrity. Genetic studies suggest that the PKMTs SUV420H1 and SUV420H2 facilitate proficient nonhomologous end-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa83d9f95eebf4a7288c158fbe1c7aaf
https://doi.org/10.1038/nchembio.2282
https://doi.org/10.1038/nchembio.2282
Autor:
Niru B. Soni, Eric F. Johnson, Joel D. Leverson, Thomas D. Penning, Keith W. Woods, Yan Shi, Loren M. Lasko, Julie M. Miyashiro, Alan S. Florjancic, E. K.-H. Han, Chunqiu Lai, Alexander R. Shoemaker, Yunsong Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1940-1943
We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (K(i)) less than 1nM. Kinase selectivity is reasonable and cytotoxicity corresponds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf3f74c76d9ced20f6761e60f152a42
https://doi.org/10.1016/j.bmcl.2012.01.041
https://doi.org/10.1016/j.bmcl.2012.01.041
Autor:
David R. Reuter, Patrick A. Marcotte, Niru B. Soni, Amanda M. Olson, Jennifer J. Bouska, Yujia Dai, Lori J. Pease, Donald J. Osterling, Kresna Hartandi, Daniel H. Albert, Keith B. Glaser, Stella Z. Doktor, Kent D. Stewart, Steven K. Davidsen, Michael R. Michaelides
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:386-390
Tumor angiogenesis is mediated by KDR and other VEGFR and PDGFR kinases. Their inhibition presents an attractive approach for developing anticancer therapeutics. Here, we report a series of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitarge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1fe6f2e83f5001005ed414b7c94447
https://doi.org/10.1016/j.bmcl.2007.10.018
https://doi.org/10.1016/j.bmcl.2007.10.018
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5518c2506c2d9a00a67d68a32abac6
https://doi.org/10.1111/j.1747-0285.2007.00521.x
https://doi.org/10.1111/j.1747-0285.2007.00521.x
Autor:
Melinda Yates, Lori J. Pease, Patrick A. Marcotte, Jennifer J. Bouska, Niru B. Soni, Daniel H. Albert, Robin R. Frey, Steven K. Davidsen, Michael L. Curtin, Keith B. Glaser, Michael R. Michaelides, Peter J. Dandliker, Asma A Ahmed, Paul Rafferty, Kent D. Stewart, Maria D Moskey, Candace Black-Schaefer, Peter F. Bousquet, H. Robin Heyman, George A. Cunha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1246-1249
A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0affa478acc38849cf981621ca7094cd
https://doi.org/10.1016/j.bmcl.2006.12.015
https://doi.org/10.1016/j.bmcl.2006.12.015
Autor:
Niru B. Soni, Rolf Wagner, Steve D. Pratt, Teresa A. Rosenberg, Linda E. Chovan, Darlene J. Balli, Candace Black-Schaefer, Angela M. Nilius, Philip J. Merta, Moshe Weitzberg, Mira M. Hinman, Bruce A. Beutel, Frank L. Wagenaar, Douglas Kalvin
Publikováno v:
Journal of Medicinal Chemistry. 49:4842-4856
We describe the synthesis and antibacterial activity of a series of tetracyclic naphthyridones. The members of this series act primarily via inhibition of bacterial translation and belong to the class of novel ribosome inhibitors (NRIs). In this pape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3055d76c6d0264564a99b3d72a37d9
https://doi.org/10.1021/jm060010w
https://doi.org/10.1021/jm060010w
Autor:
Richard F. Clark, Xiaoan Ruan, Xiaoling Xuei, Rolf Wagner, Ping Zhong, Caroline A. David, Steve D. Pratt, Moshe Weitzberg, Candace Black-Schaefer, Linus L. Shen, Peter J. Dandliker, Yingna Cai, Erika E. Englund, Stephan J. Kakavas, Angela M. Nilius, Niru B. Soni, Mai Bui, Melissa M. Daly, Philip J. Merta, Danli L. Towne, Bruce A. Beutel, Linda E. Chovan, Zhensheng Cao, Robert K. Hickman, Anne Y. Saiki, Claude G. Lerner
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:3831-3839
We report the discovery and characterization of a novel ribosome inhibitor (NRI) class that exhibits selective and broad-spectrum antibacterial activity. Compounds in this class inhibit growth of many gram-positive and gram-negative bacteria, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552703c8ab33220cee707975bca5b007
https://doi.org/10.1128/aac.47.12.3831-3839.2003
https://doi.org/10.1128/aac.47.12.3831-3839.2003
Publikováno v:
Nature Chemical Biology. 7:200-202
Although it is increasingly being recognized that drug-target interaction networks can be powerful tools for the interrogation of systems biology and the rational design of multitargeted drugs, there is no generalized, statistically validated approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3950f6d694e94d2c5a40fdd4a0e1aaf6
https://doi.org/10.1038/nchembio.530
https://doi.org/10.1038/nchembio.530
Autor:
Yan Luo, Kent D. Stewart, Owen McCall, Vincent L. Giranda, Sheela A. Thomas, Thomas J. Sowin, Yunsong Tong, Eric F. Johnson, Joel D. Leverson, Thomas D. Penning, Nan-Horng Lin, Vered Klinghofer, Magdalena Przytulinska, Niru B. Soni
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5206-5208
A series of isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones were synthesized as potent inhibitors against Pim-1 and Pim-2 kinases. The structure–activity-relationship studies started from a high-throughput screening hit and was guided by molecular mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034d8e47d27135c914eb9d720432ec04
https://doi.org/10.1016/j.bmcl.2008.08.079
https://doi.org/10.1016/j.bmcl.2008.08.079
Autor:
Niru B. Soni, Steven K. Davidsen, Lori J. Pease, Zhiwen Guan, H. Robin Heyman, Patrick A. Marcotte, Amanda M. Olson, James S. Polakowski, Jennifer J. Bouska, Kent D. Stewart, Robin R. Frey, Michael R. Michaelides, Daniel H. Albert, Chris Tse, Michael L. Curtin, Lee C. Preusser, Donald J. Osterling, Terrance J. Magoc, Keith B. Glaser, Paul Tapang
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
In an effort to identify multi-targeted kinase inhibitors with a novel spectrum of kinase activity, a screen of Abbott proprietary KDR inhibitors against a broad panel of kinases was conducted and revealed a series of thienopyridine ureas with promis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c99d66a1972bb151f3489fd31cd6e73
https://pubmed.ncbi.nlm.nih.gov/22465635
https://pubmed.ncbi.nlm.nih.gov/22465635