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of 22
pro vyhledávání: '"Niroshini M. Giles"'
Autor:
Gregory I. Giles, James D. Crowley, Dan Preston, Samantha M. McNeill, Niroshini M. Giles, Peter P. Jones
Publikováno v:
Chemical Research in Toxicology. 33:1822-1834
[Pd2(hextrz)4]4+ is a quadruply stranded helicate, a novel bio-inorganic complex designed to mimic the structure and function of proteins due to its high stability and supramolecular size. We have ...
Autor:
Samantha M, McNeill, Niroshini M, Giles, Dan, Preston, Peter P, Jones, James D, Crowley, Gregory I, Giles
Publikováno v:
Chemical research in toxicology. 33(7)
[Pd
Publikováno v:
Data in Brief
Data in Brief, Vol 8, Iss, Pp 207-210 (2016)
Data in Brief, Vol 8, Iss, Pp 207-210 (2016)
We have recently reported SAR data describing the pharmacological activity of a series of phenyl alkyl selenides and tellurides which catalyse the oxidation of thiols by hydrogen peroxide (H2O2), “The design of redox active thiol peroxidase mimics:
Autor:
Niroshini M. Giles, Chun W. W. Yuen, Emilie M. F. Billaud, Gregory I. Giles, Sweta Kumari, Bevan P. Gang
Publikováno v:
Chemical Biology & Drug Design. 80:471-478
Nitric oxide is a small messenger molecule utilized by nature in cell signalling and the non-specific immune response. At present, nitric oxide releasing prodrugs cannot be efficiently targeted towards a specific body compartment, which restricts the
Publikováno v:
Anticancer research. 35(9)
Synthetic cannabinoid WIN55,212-2 (WIN) has shown a promise as an anticancer agent but causes psychoactive side-effects. In the present study, nano-micelles of styrene maleic acid (SMA)-conjugated WIN were synthesized to reduce side-effects and incre
Autor:
Joo Yeun Oh, Jaroslaw W. Zmijewski, Nobuo Watanabe, Victor M Darley–Usmar, Aimee Landar, Niroshini M. Giles
Publikováno v:
Future Lipidology. 1:203-211
The full characterization of the lipid content of the cell, the lipidome, is now emerging as a new approach to understand how lipid molecules modulate cellular function. As with the proteome, the lipidome can be extended by modification of the lipid
Publikováno v:
Biochemical Pharmacology. 66:2021-2028
Tumor cells proliferate under conditions of oxidative stress. A novel therapeutic approach would be to enhance the cellular effects of the reactive oxygen species formed under these conditions by supplementation with a redox catalyst. This provides a
Publikováno v:
Angewandte Chemie. 115:4890-4907
Schwefel und Selen kommen in Proteinen als Bestandteile der Aminosauren Cystein, Methionin, Selenocystein und Selenomethionin vor, deren Ausnahmestellung in neueren Arbeiten unterstrichen wird. Ihre Redoxeigenschaften unter physiologischen Bedingunge
Autor:
Jennifer A. Littlechild, Niroshini M. Giles, Gregory I. Giles, Aaron B. Watts, Claus Jacob, Fiona H. Fry
Publikováno v:
Chemistry & Biology. 10:677-693
In biological systems, the amino acid cysteine combines catalytic activity with an extensive redox chemistry and unique metal binding properties. The interdependency of these three aspects of the thiol group permits the redox regulation of proteins a
Publikováno v:
FEBS Letters. 535:179-182
The predominance of oxidative stress in many tumour cell environments provides a means to selectively target these cells via protein oxidation. The zinc fingers of transcription factors utilise cysteine thiols for structural zinc coordination. Redox