Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nirmesh Patel"'
Autor:
Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita Grigoriadis, Spiros Linardopoulos, Pierfrancesco Marra, Andrew N. J. Tutt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions a
Externí odkaz:
https://doaj.org/article/5040e6ddb1d140d09e37fbc06a8ca400
Autor:
Ionut Dragomir, Adnan Akbar, John W. Cassidy, Nirmesh Patel, Harry W. Clifford, Gianmarco Contino
Publikováno v:
Cancers, Vol 13, Iss 11, p 2779 (2021)
Sporadic cancer develops from the accrual of somatic mutations. Out of all small-scale somatic aberrations in coding regions, 95% are base substitutions, with 90% being missense mutations. While multiple studies focused on the importance of this muta
Externí odkaz:
https://doaj.org/article/925c18df3044497b8ef511f1fc3abadd
Autor:
Sophia N. Karagiannis, Andrew N.J. Tutt, Anita Grigoriadis, James F. Spicer, Cheryl Gillett, Frank O. Nestle, Sarah Pinder, Mariangela Figini, Silvana Canevari, Debra H. Josephs, Daniel Larcombe-Young, Gyula Petranyi, Silvia Crescioli, Heather J. Bax, Giulia Pellizzari, Silvia Mele, Nirmesh Patel, Luned Badder, Angela Clifford, Diana Dominguez Rodriguez, Matthew Fittall, Erika Francesch-Domenech, Rebecca Marlow, Hasan Mirza, Ricarda M. Hoffmann, Patrycja Gazinska, Kristina M. Ilieva, James Opzoomer, Anthony Cheung
Purpose: Highly aggressive triple-negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeced1d042d1dc7c01723a2468cd543
https://doi.org/10.1158/1078-0432.c.6529226
https://doi.org/10.1158/1078-0432.c.6529226
Autor:
Sophia N. Karagiannis, Andrew N.J. Tutt, Anita Grigoriadis, James F. Spicer, Cheryl Gillett, Frank O. Nestle, Sarah Pinder, Mariangela Figini, Silvana Canevari, Debra H. Josephs, Daniel Larcombe-Young, Gyula Petranyi, Silvia Crescioli, Heather J. Bax, Giulia Pellizzari, Silvia Mele, Nirmesh Patel, Luned Badder, Angela Clifford, Diana Dominguez Rodriguez, Matthew Fittall, Erika Francesch-Domenech, Rebecca Marlow, Hasan Mirza, Ricarda M. Hoffmann, Patrycja Gazinska, Kristina M. Ilieva, James Opzoomer, Anthony Cheung
Supplementary Figure Legends, Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1364e8eabda189fe66060ac2fce20e20
https://doi.org/10.1158/1078-0432.22475951.v1
https://doi.org/10.1158/1078-0432.22475951.v1
Autor:
Sophia N. Karagiannis, Andrew N.J. Tutt, Anita Grigoriadis, James F. Spicer, Cheryl Gillett, Frank O. Nestle, Sarah Pinder, Mariangela Figini, Silvana Canevari, Debra H. Josephs, Daniel Larcombe-Young, Gyula Petranyi, Silvia Crescioli, Heather J. Bax, Giulia Pellizzari, Silvia Mele, Nirmesh Patel, Luned Badder, Angela Clifford, Diana Dominguez Rodriguez, Matthew Fittall, Erika Francesch-Domenech, Rebecca Marlow, Hasan Mirza, Ricarda M. Hoffmann, Patrycja Gazinska, Kristina M. Ilieva, James Opzoomer, Anthony Cheung
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d20174849139c56758152834cf2e36
https://doi.org/10.1158/1078-0432.22475948
https://doi.org/10.1158/1078-0432.22475948
Autor:
Adnan Akbar, Nirmesh Patel, Ionut Dragomir, Harry W. Clifford, John W. Cassidy, Gianmarco Contino
Publikováno v:
Cancers, Vol 13, Iss 2779, p 2779 (2021)
Cancers
Volume 13
Issue 11
Cancers
Volume 13
Issue 11
Simple Summary Genes dictate the grounds of life by comprising molecular bases which encode proteins. A mutation represents a gene modification that may influence the protein function. Cancer occurs when the mutation triggers uncontrolled cellular gr
Autor:
Anthony Cheung, Diana Dominguez Rodriguez, Mariangela Figini, James Spicer, Anita Grigoriadis, Cheryl Gillett, Nirmesh Patel, James W. Opzoomer, Angela Clifford, Matthew Fittall, Giulia Pellizzari, Patrycja Gazinska, Hasan Mirza, Luned M. Badder, Andrew Tutt, Frank O. Nestle, Daniel Larcombe-Young, Silvia Mele, Debra H. Josephs, Rebecca Marlow, Sophia N. Karagiannis, Silvia Crescioli, Sarah E Pinder, Heather J. Bax, Gyula M. Petranyi, Erika Francesch-Domenech, Silvana Canevari, Ricarda M. Hoffmann, Kristina M. Ilieva
Publikováno v:
Cheung, A, Opzoomer, J W, Ilieva, K M, Gazinska, P, Hoffmann, R M, Mirza, H, Marlow, R, Francesch-Domenech, E, Fittall, M W, Dominguez Rodriguez, D, Clifford, A, Badder, L, Patel, N, Mele, S, Pellizzari, G, Bax, H J, Crescioli, S, Petranyi, G, Larcombe-Young, D, Josephs, D H, Canevari, S, Figini, M, Pinder, S E, Nestle, F O, Gillett, C, Spicer, J, Grigoriadis, A, Tutt, A & Karagiannis, S N 2018, ' Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer ', Clinical Cancer Research, vol. 24, no. 20, pp. 5098-5111 . https://doi.org/10.1158/1078-0432.CCR-18-0652
Purpose: Highly aggressive triple-negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3bf16519826e1575a3ac479dab144a
https://kclpure.kcl.ac.uk/en/publications/8d47713f-0302-4f11-8ad1-211948bd6f02
https://kclpure.kcl.ac.uk/en/publications/8d47713f-0302-4f11-8ad1-211948bd6f02
Autor:
Nirmesh, Patel, Daniel, Weekes, Konstantinos, Drosopoulos, Patrycja, Gazinska, Elodie, Noel, Mamun, Rashid, Hasan, Mirza, Jelmar, Quist, Fara, Brasó-Maristany, Sumi, Mathew, Riccardo, Ferro, Ana Mendes, Pereira, Cynthia, Prince, Farzana, Noor, Erika, Francesch-Domenech, Rebecca, Marlow, Emanuele, de Rinaldis, Anita, Grigoriadis, Spiros, Linardopoulos, Pierfrancesco, Marra, Andrew N J, Tutt
Publikováno v:
Patel, N, Weekes, D, Drosopoulos, K, Gazinska, P, Noel, E, Rashid, M, Mirza, H, Quist, J, Brasó-Maristany, F, Mathew, S, Ferro, R, Pereira, A M, Prince, C, Noor, F, Francesch-Domenech, E, Marlow, R, de Rinaldis, E, Grigoriadis, A, Linardopoulos, S, Marra, P & Tutt, A N J 2018, ' Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer ', Nature Communications, vol. 9, no. 1, 1044 . https://doi.org/10.1038/s41467-018-03283-z
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Triple negative breast cancers (TNBCs) lack recurrent targetable driver mutations but demonstrate frequent copy number aberrations (CNAs). Here, we describe an integrative genomic and RNAi-based approach that identifies and validates gene addictions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::364282ebfd9cfb5866f824e8e053da52
https://kclpure.kcl.ac.uk/ws/files/111402468/Integrated_genomics_and_functional_PATEL_Accepted_1_February_2018_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/111402468/Integrated_genomics_and_functional_PATEL_Accepted_1_February_2018_GOLD_VoR_CC_BY_.pdf
Autor:
Zakka L, Pascal Meier, Pierfrancesco Marra, Plumb Da, Maurizio Scaltriti, Patrycja Gazinska, Anita Grigoriadis, Steven Catchpole, Erika Francesch-Domenech, McEachern K, Johnathan Watkins, Fara Braso-Maristany, Sumi Mathew, Simone Filosto, Andrew Tutt, Nirmesh Patel, Pau Castel, Perdrix-Rosell A, Elodie Noel, Rebecca Marlow, Gianmaria Liccardi, Maggie C.U. Cheang, Albert Gris-Oliver, Manar S. Shafat, Jelmar Quist, Serra, Farzana Noor, Richard Buus
Publikováno v:
Nature medicine. 22(11)
Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with TNBC. TNBC cells, but not nonmalignant ma
Autor:
Ana Mendes Pereira, Virinder Reen, Fara Braso' Maristany, Hasan Mirza, Riccardo Ferro, Dragomir B. Krastev, Farzana Noor, Anita Grigoriadis, Pierfrancesco Marra, Tencho Tenev, Alessandra Facchetti, David Robertson, Priyanka Ghongane-Salpe, Patrycja Gazinska, Nirmesh Patel, Andrew Tutt, Sedigeh Kareemaghay, Daniel Weekes, Sumi Mathew, Cynthia Prince
Publikováno v:
Cancer Research. 78:443-443
In order to identify novel tumor drivers and gene addictions in breast cancer we have recently completed an integrated in silico/in vitro analysis of gene copy-number alterations and gene-expression profiles in a Triple Negative Breast Cancer-enriche