Výsledky vyhledávání - "Nirmala D. Kanika"

Smooth muscle myosin expression, isoform composition, and functional activities in rat corpus cavernosum altered by the streptozotocin-induced type 1 diabetes

Autor: Arnold Melman, Xinhua Zhang, Michael E. DiSanto, Nirmala D. Kanika

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 302:E32-E42

Diabetes mellitus (DM) is a quite common chronic disease, and the prevalence of erectile dysfunction (ED) is three times higher in this large population. Although diabetes-related ED has been studied extensively, the actin-myosin contractile apparatu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf6a4c974abb3827102b19f41b2d64f
https://doi.org/10.1152/ajpendo.00231.2011

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Reversal of diabetic vasculopathy in a rat model of type 1 diabetes by opiorphin-related peptides

Autor: Yuehong Tong, Moses Tar, Catherine Rougeot, Arnold Melman, Sylvia O. Suadicani, Giulia Calenda, Nirmala D. Kanika, Kelvin P. Davies, Xinhua Zhang

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 301:H1353-H1359

Diabetes results in a myriad of vascular complications, often referred to as diabetic vasculopathy, which encompasses both microvascular [erectile dysfunction (ED), retinopathy, neuropathy, and nephropathy] and macrovascular complications (hypertensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2cd248f9b2e25c540fc016f472ab64
https://doi.org/10.1152/ajpheart.00383.2011

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Experimental Priapism is Associated with Increased Oxidative Stress and Activation of Protein Degradation Pathways in Corporal Tissue

Autor: Arnold Melman, Nirmala D. Kanika, Kelvin P. Davies

Publikováno v: International journal of impotence research

Priapism is a debilitating disease for which there is at present no clinically accepted pharmacologic intervention. It has been estimated that priapism lasting more than 24 hours in patients is associated with a 44–90% rate of erectile dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b327b0b7940a1734e55f20f6e450a4ab
http://europepmc.org/articles/PMC3058910

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Oxidative stress status accompanying diabetic bladder cystopathy results in the activation of protein degradation pathways

Autor: Scott I. Tiplitsky, Yuehong Tong, Mark R. Chance, Arnold Melman, George J. Christ, Kelvin Davies, Nirmala D. Kanika, Juan Lin, Elizabeth Yohannes, Moses Tar, Jinsook Chang

Publikováno v: BJU International. 107:1676-1684

What’s known on the subject? and What does the study add? Diabetes is a common precursor for ladder pathology, including detrusor overactivity and cystopathy. There is preliminary, but increasing evidence, suggesting that oxidative stress plays a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c01813a05a7f81af92f2837f7dd71bd
https://doi.org/10.1111/j.1464-410x.2010.09655.x

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The mechanism of opiorphin-induced experimental priapism in rats involves activation of the polyamine synthetic pathway

Autor: Yuehong Tong, Nirmala D. Kanika, Kelvin P. Davies, Arnold Melman, Dwaraka Kuppam, Moses Tar

Publikováno v: American Journal of Physiology-Cell Physiology. 297:C916-C927

Intracorporal injection of plasmids encoding opiorphins into retired breeder rats can result in animals developing a priapic-like condition. Microarray analysis demonstrated that following intracorporal gene transfer of plasmids expressing opiorphins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4e07ccf22da5ebb20f55d60af9515a
https://doi.org/10.1152/ajpcell.00656.2008

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Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation

Autor: Seetharama A. Acharya, Marcos Intaglietta, Belur N. Manjula, Amy G. Tsai, Vivek N. Acharya, Nirmala D. Kanika

Publikováno v: Biochemical Journal. 405:503-511

TetraPEGylated canine Hb, [SP (succinimidophenyl)-PEG5K]4-canine-Hb, with PEGylation at its four reactive cysteine residues (α111 and β93) has been prepared and characterized. The hydrodynamic volume and the molecular radius of (SP-PEG5K)4-canine-H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeab9d5a71c2c02c0dc61f1eb09cb39
https://doi.org/10.1042/bj20070238

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AB302. SPR-29 Sphingosine-1-phosphate in vitro and in vivo modulates corpus cavernosum smooth muscle tone

Autor: Michael E. DiSanto, Arnold Melman, Yuehong Tong, Guillermo Villegas, Nirmala D. Kanika, Jing Yin, Xinhua Zhang

Publikováno v: Translational Andrology and Urology

Objective The bioactive lipid sphingosine-1-phosphate (S1P) regulates smooth muscle (SM) contractility predominantly via three G protein-coupled receptors. The S1P1 receptor is associated with nitric oxide-mediated SM relaxation while S1P2 & S1P3 rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9aeedfd0be0ecd4f49474614da7cb83
https://doi.org/10.21037/tau.2016.s302

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