Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nirjal Mainali"'
Autor:
Meenakshisundaram Balasubramaniam, Akshatha Ganne, Nirjal Mainali, Sonu Pahal, Srinivas Ayyadevara, Robert J. Shmookler Reis
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108745- (2024)
Summary: Alzheimer’s disease (AD) is characterized by peri-neuronal amyloid plaque and intra-neuronal neurofibrillary tangles. These aggregates are identified by the immunodetection of “seed” proteins (Aβ1–42 and hyperphosphorylated tau, res
Externí odkaz:
https://doaj.org/article/0fe45e0d266e41429a8d9af0ceeefb36
Autor:
Samuel Kakraba, Srinivas Ayyadevara, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Suresh Bowroju, Narsimha Reddy Penthala, Ramani Atluri, Steven W. Barger, Sue T. Griffin, Peter A. Crooks, Robert J. Shmookler Reis
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1498 (2023)
Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer’s disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which
Externí odkaz:
https://doaj.org/article/5ef6117e54514590994189c991ada0a2
Autor:
Suresh K. Bowroju, Nirjal Mainali, Srinivas Ayyadevara, Narsimha R. Penthala, Sesha Krishnamachari, Samuel Kakraba, Robert J. Shmookler Reis, Peter A. Crooks
Publikováno v:
Molecules, Vol 25, Iss 16, p 3610 (2020)
A series of novel hybrid 8-hydroxyquinoline-indole derivatives (7a–7e, 12a–12b and 18a–18h) were synthesized and screened for inhibitory activity against self-induced and metal-ion induced Aβ1–42 aggregation as potential treatments for Alzhe
Externí odkaz:
https://doaj.org/article/1b439427331f4c8ab52a9e002f075f26
Autor:
Narsimha Reddy Penthala, Robert J. Shmookler Reis, Srinivas Ayyadevera, Nirjal Mainali, Peter A. Crooks, Suresh K. Bowroju, Paavan Atluri, Meenakshisundaram Balasubramaniam
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Glycogen synthase kinase-3β (GSK3β) controls many physiological pathways, and is implicated in many diseases including Alzheimer’s and several cancers. GSK3β-mediated phosphorylation of target residues in microtubule-associated protein tau (MAPT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ddce38dcaa1db1ecc7f864852fee78
https://doi.org/10.1038/s41598-020-75020-w
https://doi.org/10.1038/s41598-020-75020-w
Autor:
Peter A. Crooks, Narsimha Reddy Penthala, Samuel Kakraba, Robert J. Shmookler Reis, Nirjal Mainali, Srinivas Ayyadevara, Suresh K. Bowroju, Sesha Krishnamachari
Publikováno v:
Molecules, Vol 25, Iss 3610, p 3610 (2020)
Molecules
Volume 25
Issue 16
Molecules
Volume 25
Issue 16
A series of novel hybrid 8-hydroxyquinoline-indole derivatives (7a–7e, 12a–12b and 18a–18h) were synthesized and screened for inhibitory activity against self-induced and metal-ion induced Aβ1–42 aggregation as potential treatments for Alzhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683025fdddee8c8cd34da02e3a8a71b8
https://www.mdpi.com/1420-3049/25/16/3610
https://www.mdpi.com/1420-3049/25/16/3610