Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nirit Z. Kara"'
Autor:
S. Natour, H. Einat, Nirit Z. Kara, Serena Asslih, Nofar Shemesh, A. Daraushe, G. Las, O. Noori, Odeya Damri, Galila Agam
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
We mimicked mild mitochondrial-distress robustly reported in bipolar-disorder (BD) by chronic exposure to uniquely low doses of inhibitors of mitochondrial-respiration complexes in vitro and in vivo. Exposure of the neuronal-originating SH-SY5Y cells
Publikováno v:
Journal of neuroscience methods. 346
Background There is a desperate need for in-vivo behavioral screening tests for anti-manic effects. The frequently used psychostimulant-induced hyperactivity test appears to have lower validity than previously described, but other quick, simple and h
Publikováno v:
Pharmacology. 102:281-286
Background: Lithium (Li) is the prototypic mood-stabilizing drug, but the individual response to Li is highly heterogeneous. Some evidence suggest interactions between Li and stress, and it is possible to hypothesize that lithium’s effects are modi
Publikováno v:
Behavioural Brain Research. 317:576-580
The acute antidepressant effects of ketamine provide hope for the development of a fast acting approach to treat depression but the consequences of chronic treatment with ketamine are still unclear. One theory regarding the acute effect is that ketam
Publikováno v:
Pharmacological Reports. 67:928-933
Background AMPA receptors are highly expressed throughout the central nervous system and are suggested to be involved in mood regulation. Studies found changes in glutamate, its metabolites and receptors in patients with bipolar disorder (BPD) or maj
Publikováno v:
Behavioural Pharmacology. 26:331-337
Asenapine is indicated for the treatment of schizophrenia and manic episodes in bipolar disorder (BPD). There is a paucity of information on the effects of asenapine in animal models of BPD, but such work is essential to discover its scope of effects
Publikováno v:
Psychopharmacology. 229:367-375
The disaccharide trehalose protects cells from hypoxic and anoxic injury and suppresses protein aggregation. In vivo studies with trehalose show cellular and behavioral beneficial effects in animal models of neurodegenerative diseases. Moreover, treh
Autor:
Haim Einat, Nirit Z. Kara
Publikováno v:
Cell and Tissue Research. 354:191-201
The scarcity of good animal models for bipolar disorder (BPD) and especially for mania is repeatedly mentioned as one of the rate-limiting factors in the process of gaining a better understanding into its pathophysiology and of developing better trea
Publikováno v:
Acta neuropsychiatrica. 28(2)
ObjectiveA number of atypical antipsychotic drugs were demonstrated to have anxiolytic effects in patients and in animal models. These effects were mostly suggested to be the consequence of the drugs’ affinity to the serotonin system and its recept