Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Nirav Malani"'
Autor:
Joseph A Giovinazzo, Russell P Thomson, Nailya Khalizova, Patrick J Zager, Nirav Malani, Enrique Rodriguez-Boulan, Jayne Raper, Ryan Schreiner
Publikováno v:
eLife, Vol 9 (2020)
Recently evolved alleles of Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infectio
Externí odkaz:
https://doaj.org/article/1efab0b621c4423f824ff25de7c99d4e
Autor:
Charles C. Berry, Christopher Nobles, Emmanuelle Six, Yinghua Wu, Nirav Malani, Eric Sherman, Anatoly Dryga, John K. Everett, Frances Male, Aubrey Bailey, Kyle Bittinger, Mary J. Drake, Laure Caccavelli, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 17-26 (2017)
Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take
Externí odkaz:
https://doaj.org/article/f6f59b94b4594769ac2569d51c8c88e1
Autor:
Eric Sherman, Christopher Nobles, Charles C. Berry, Emmanuelle Six, Yinghua Wu, Anatoly Dryga, Nirav Malani, Frances Male, Shantan Reddy, Aubrey Bailey, Kyle Bittinger, John K. Everett, Laure Caccavelli, Mary J. Drake, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 39-49 (2017)
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy. Tracking the distributions of integration sites is important to characteriz
Externí odkaz:
https://doaj.org/article/3427f2d0dfcc4d91928bb6ad271ea637
Autor:
Jan De Rijck, Christine de Kogel, Jonas Demeulemeester, Sofie Vets, Sara El Ashkar, Nirav Malani, Frederic D. Bushman, Bart Landuyt, Steven J. Husson, Katrien Busschots, Rik Gijsbers, Zeger Debyser
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 886-894 (2013)
A hallmark of retroviral replication is integration of the viral genome into host cell DNA. This characteristic makes retrovirus-based vectors attractive delivery vehicles for gene therapy. However, adverse events in gene therapeutic trials, caused b
Externí odkaz:
https://doaj.org/article/b8aafdc87e7a41b4a5bfc8e5be5df5a4
Autor:
Amit Sharma, Alison Slaughter, Nivedita Jena, Lei Feng, Jacques J Kessl, Hind J Fadel, Nirav Malani, Frances Male, Li Wu, Eric Poeschla, Frederic D Bushman, James R Fuchs, Mamuka Kvaratskhelia
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004171 (2014)
The quinoline-based allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are promising candidates for clinically useful antiviral agents. Studies using these compounds have highlighted the role of IN in both early and late stages of virus replication
Externí odkaz:
https://doaj.org/article/7ceda5ee2d6f497c8ecf7da87f9b4d83
Autor:
Josiah Petersen, Mary Jane Drake, Emily A Bruce, Amber M Riblett, Chukwuka A Didigu, Craig B Wilen, Nirav Malani, Frances Male, Fang-Hua Lee, Frederic D Bushman, Sara Cherry, Robert W Doms, Paul Bates, Kenneth Briley
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003911 (2014)
The Bunyaviridae comprise a large family of RNA viruses with worldwide distribution and includes the pathogenic New World hantavirus, Andes virus (ANDV). Host factors needed for hantavirus entry remain largely enigmatic and therapeutics are unavailab
Externí odkaz:
https://doaj.org/article/f0959b3fb26345a8ad77874cb23e408f
Autor:
Lauren E Woodard, Xianghong Li, Nirav Malani, Aparna Kaja, Robert H Hice, Peter W Atkinson, Frederic D Bushman, Nancy L Craig, Matthew H Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e42666 (2012)
Transposons are useful tools for creating transgenic organisms, insertional mutagenesis, and genome engineering. TcBuster, a novel hAT-family transposon system derived from the red flour beetle Tribolium castaneum, was shown to be highly active in pr
Externí odkaz:
https://doaj.org/article/5511c535cd80440f85ae9ef7d8b50f3c
Autor:
Karen E Ocwieja, Troy L Brady, Keshet Ronen, Alyssa Huegel, Shoshannah L Roth, Torsten Schaller, Leo C James, Greg J Towers, John A T Young, Sumit K Chanda, Renate König, Nirav Malani, Charles C Berry, Frederic D Bushman
Publikováno v:
PLoS Pathogens, Vol 7, Iss 3, p e1001313 (2011)
Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358 and the karyopherin Transportin-3/TNPO3. Analysis of the roles of these proteins in the HIV
Externí odkaz:
https://doaj.org/article/f25183735b154f4b95512dccdb88946b
Autor:
Claudia Cattoglio, Giulietta Maruggi, Cynthia Bartholomae, Nirav Malani, Danilo Pellin, Fabienne Cocchiarella, Zulma Magnani, Fabio Ciceri, Alessandro Ambrosi, Christof von Kalle, Frederic D Bushman, Chiara Bonini, Manfred Schmidt, Fulvio Mavilio, Alessandra Recchia
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15688 (2010)
The infusion of donor lymphocytes transduced with a retroviral vector expressing the HSV-TK suicide gene in patients undergoing hematopoietic stem cell transplantation for leukemia/lymphoma promotes immune reconstitution and prevents infections and g
Externí odkaz:
https://doaj.org/article/49f1726fa87446f294982fc3f460ecb0
Autor:
Frederic D Bushman, Nirav Malani, Jason Fernandes, Iván D'Orso, Gerard Cagney, Tracy L Diamond, Honglin Zhou, Daria J Hazuda, Amy S Espeseth, Renate König, Sourav Bandyopadhyay, Trey Ideker, Stephen P Goff, Nevan J Krogan, Alan D Frankel, John A T Young, Sumit K Chanda
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000437 (2009)
We have analyzed host cell genes linked to HIV replication that were identified in nine genome-wide studies, including three independent siRNA screens. Overlaps among the siRNA screens were very modest (
Externí odkaz:
https://doaj.org/article/8367ca4bba4e49f2bad41a3007e87ed2