Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Nirav Dhanesha"'
Autor:
Richa Aishwarya, Chowdhury S. Abdullah, Naznin Sultana Remex, Mohammad Alfrad Nobel Bhuiyan, Xiao-Hong Lu, Nirav Dhanesha, Karen Y. Stokes, A. Wayne Orr, Christopher G. Kevil, Md. Shenuarin Bhuiyan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Alzheimer's Disease (AD) is a progressive neurodegenerative disease caused by the deposition of Aβ aggregates or neurofibrillary tangles. AD patients are primarily diagnosed with the concurrent development of several cardiovascular dysfunct
Externí odkaz:
https://doaj.org/article/48fd05b784bd4ac59164a45065a5bc38
Autor:
Prakash Doddapattar, Rishabh Dev, Madankumar Ghatge, Rakeshkumar Patel, Manish Jain, Nirav Dhanesha, Steven R. Lentz, Anil K. Chauhan
Publikováno v:
JVS - Vascular Science, Vol 3, Iss , Pp 420- (2022)
Externí odkaz:
https://doaj.org/article/0d167df5b5434a58b0f90583dd06b1b8
Autor:
Manish Jain, Rishabh Dev, Prakash Doddapattar, Shigeyuki Kon, Nirav Dhanesha, Anil K. Chauhan
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Excessive proliferation of vascular smooth muscle cells (SMCs) remains a significant cause of in-stent restenosis. Integrins, which are heterodimeric transmembrane receptors, play a crucial role in SMC biology by binding to the extracellular matrix p
Externí odkaz:
https://doaj.org/article/12712e6ca6e9479eada3274d2c28b3c0
Autor:
Manasa K. Nayak, Nirav Dhanesha, Prakash Doddapattar, Omar Rodriguez, Vijay K. Sonkar, Sanjana Dayal, Anil K. Chauhan
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 2029-2038 (2018)
Abstract: Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis (conversion of glucose to lactate in the presence of oxygen) to generate adenosine triphosphate, whereas activated platelets exhibit a high level of aerobic
Externí odkaz:
https://doaj.org/article/0dc783ca8a2c4854901e37d2f8243550
Publikováno v:
Archives of Pharmacal Research. 46:361-388
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26c78db1fff77b0c14902c916128c2ea
https://doi.org/10.1007/s12272-023-01447-0
https://doi.org/10.1007/s12272-023-01447-0
Autor:
Patrick D. Lyden, Francesca Bosetti, Márcio A. Diniz, André Rogatko, James I. Koenig, Jessica Lamb, Karisma A. Nagarkatti, Ryan P. Cabeen, David C. Hess, Pradip K. Kamat, Mohammad B. Khan, Kristofer Wood, Krishnan Dhandapani, Ali S. Arbab, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Andreia Morais, Takahiko Imai, Tao Qin, Cenk Ayata, Ligia S.B. Boisserand, Alison L. Herman, Hannah E. Beatty, Sofia E. Velazquez, Sebastian Diaz-Perez, Basavaraju G. Sanganahalli, Jelena M. Mihailovic, Fahmeed Hyder, Lauren H. Sansing, Raymond C. Koehler, Steven Lannon, Yanrong Shi, Senthilkumar S. Karuppagounder, Adnan Bibic, Kazi Akhter, Jaroslaw Aronowski, Louise D. McCullough, Anjali Chauhan, Andrew Goh, Shahneela Siddiqui, Kevin Sheth, Charles Matouk, Charles Dela Cruz, Jiangbing Zhou, Valina L. Dawson, Ted M. Dawson, Jian Liang, Peter C.M. van Zijl, Steven R. Zeiler, W. Taylor Kimberly, Taylan Erdogan, Lili Yu, Joseph Mandeville, Jonah Patrick Weigand Whittier
Publikováno v:
Stroke
Cerebral ischemia and reperfusion initiate cellular events in brain that lead to neurological disability. Investigating these cellular events provides ample targets for developing new treatments. Despite considerable work, no such therapy has transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944cca2f8b27c9045b9c0d613dc0b39c
https://doi.org/10.1161/strokeaha.121.038047
https://doi.org/10.1161/strokeaha.121.038047
Autor:
Rakeshkumar Patel, Nirav Dhanesha, Brijesh Sutariya, Madankumar Ghatge, Mariia Kumskova, Enrique C Leira, Anil K Chauhan
Publikováno v:
Stroke. 54
Background: Obesity-induced hyperglycemia is one of the significant risk factors for stroke. Integrin α9β1 is highly expressed on activated neutrophils and stabilizes adhesion to the endothelium via ligands, including tenascin C. While myeloid dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f702a466fa9a0fb269005ac4680aa0c1
https://doi.org/10.1161/str.54.suppl_1.39
https://doi.org/10.1161/str.54.suppl_1.39
Autor:
Andreia Morais, Joseph J. Locascio, Lauren H. Sansing, Jessica Lamb, Karisma Nagarkatti, Takahiko Imai, Klaus van Leyen, Jaroslaw Aronowski, James I. Koenig, Francesca Bosetti, Patrick Lyden, Cenk Ayata, Patrick D. Lyden, David C. Hess, Pradip K. Kamat, Mohammad Badruzzaman Khan, Krishnan Dhandapani, Ali S. Arbab, Shahneela Siddiqui, Cameron Smith, Mohammad Nisar, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Kai Wang, Tao Qin, Xuyan Jin, Taylan Denis Erdogan, Lili Yu, Joseph B. Mandeville, William Taylor Kimberly, Jonah Patrick Weigand Whittier, Eng Lo, Ken Arai, Klaus Van Leyen, Fahmeed Hyder, Jelena M. Mihailovic, Basavaraju G. Sanganahalli, Sebastian Diaz-Perez, Sofia E. Velazquez, Hannah E. Beatty, Conor Johnson, Alison L. Herman, Ligia S. B. Boisserand, Emma Immakavar, Raymond C. Koehler, Ted Dawson, Valina Dawson, Yanrong Shi, Brooklyn Avery, Steven Lannon, Adnan Bibic, Kazi Akhter, Senthilkumar S. Karuppagounder, Louise D. McCullough, Lidiya Obertas, Andrew Goh, Shuning Huang, Anjali Chauhan
Publikováno v:
Stroke.
The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In addition to centralized randomization an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f659344b670d29ae7ba3de319dbc2dcf
https://pubmed.ncbi.nlm.nih.gov/36601951
https://pubmed.ncbi.nlm.nih.gov/36601951
Autor:
Anil K. Chauhan, Steven R. Lentz, Manasa K. Nayak, Manish Jain, Prakash Doddapattar, Liang Guo, Anne Cornelissen, Nirav Dhanesha, Aloke V. Finn
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41:1724-1737
Objective: The role of glycolytic enzyme PKM2 (pyruvate kinase muscle 2) in smooth muscle cell (SMC) phenotype switching and neointimal hyperplasia is poorly understood. We determined the role of PKM2 in SMC phenotype switching and neointimal hyperpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc44984babce518c7cfea3be32c0c17
https://doi.org/10.1161/atvbaha.121.316021
https://doi.org/10.1161/atvbaha.121.316021
Autor:
Nirav Dhanesha, Madankumar Ghatge, Manasa K. Nayak, Steven R. Lentz, Gagan D. Flora, Matthew J. Potthoff, Kathleen R. Markan, Anil K. Chauhan, Manish Jain
Publikováno v:
Blood
Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ac31c11b1b31d3b0df4861e454c06
https://doi.org/10.1182/blood.2020007140
https://doi.org/10.1182/blood.2020007140