Výsledky vyhledávání - "Niranjana Shashikumar"

Akademický článek

Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging

Autor: Derek B. Archer, Kurt Schilling, Niranjana Shashikumar, Varuna Jasodanand, Elizabeth E. Moore, Kimberly R. Pechman, Murat Bilgel, Lori L. Beason‐Held, Yang An, Andrea Shafer, Luigi Ferrucci, Shannon L. Risacher, Katherine A. Gifford, Bennett A. Landman, Angela L. Jefferson, Andrew J. Saykin, Susan M. Resnick, Timothy J. Hohman, for the Alzheimer's Disease Neuroimaging Initiative

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)

Abstract Introduction It is unclear how rates of white matter microstructural decline differ between normal aging and abnormal aging. Methods Diffusion MRI data from several well‐established longitudinal cohorts of aging (Alzheimer's Disease Neuroi

Externí odkaz: https://doaj.org/article/20540831140341e68e8fcfd1aa55351e

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Akademický článek

White matter microstructural metrics are sensitively associated with clinical staging in Alzheimer's disease

Autor: Yisu Yang, Kurt Schilling, Niranjana Shashikumar, Varuna Jasodanand, Elizabeth E. Moore, Kimberly R. Pechman, Murat Bilgel, Lori L. Beason‐Held, Yang An, Andrea Shafer, Shannon L. Risacher, Bennett A. Landman, Angela L. Jefferson, Andrew J. Saykin, Susan M. Resnick, Timothy J. Hohman, Derek B. Archer, for the Alzheimer's Disease Neuroimaging Initiative

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)

Abstract Introduction White matter microstructure may be abnormal along the Alzheimer's disease (AD) continuum. Methods Diffusion magnetic resonance imaging (dMRI) data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 627), Baltimore L

Externí odkaz: https://doaj.org/article/76b466b757de4ea9a3c9302b583bdeda

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Akademický článek

Associations among executive function Abilities, free Water, and white matter microstructure in early old age

Autor: Daniel E. Gustavson, Derek B. Archer, Jeremy A. Elman, Olivia K. Puckett, Christine Fennema-Notestine, Matthew S. Panizzon, Niranjana Shashikumar, Timothy J. Hohman, Angela L. Jefferson, Lisa T. Eyler, Linda K. McEvoy, Michael J. Lyons, Carol E. Franz, William S. Kremen

Publikováno v: NeuroImage: Clinical, Vol 37, Iss , Pp 103279- (2023)

Background: Studies have investigated white matter microstructure in relation to late-life cognitive impairments, with fractional anisotropy (FA) and mean diffusivity (MD) measures thought to capture demyelination and axonal degradation. However, new

Externí odkaz: https://doaj.org/article/355ebd3acd9a443ea48e863f22872254

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Akademický článek

The relationship between white matter microstructure and self-perceived cognitive decline

Autor: Derek B. Archer, Elizabeth E. Moore, Ujwala Pamidimukkala, Niranjana Shashikumar, Kimberly R. Pechman, Kaj Blennow, Henrik Zetterberg, Bennett A. Landman, Timothy J. Hohman, Angela L. Jefferson, Katherine A. Gifford

Publikováno v: NeuroImage: Clinical, Vol 32, Iss , Pp 102794- (2021)

Subjective cognitive decline (SCD) is a perceived cognitive change prior to objective cognitive deficits, and although it is associated with Alzheimer’s disease (AD) pathology, it likely results from multiple underlying pathologies. We investigated

Externí odkaz: https://doaj.org/article/ce04b5b4e64046d6b765d64df02aaa46

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Axonal Injury Partially Mediates Associations Between Increased Left Ventricular Mass Index and White Matter Damage

Autor: Niranjana Shashikumar, Adam W. Anderson, Timothy J. Hohman, James G. Terry, Kimberly R. Pechman, J. Jeffrey Carr, Bennett A. Landman, Elizabeth E. Moore, Henrik Zetterberg, Dandan Liu, Katherine A. Gifford, Sangeeta Nair, Angela L. Jefferson, Susan P. Bell, Kaj Blennow, Omair A. Khan

Publikováno v: Stroke

Background and Purpose: Left ventricular (LV) mass index is a marker of subclinical LV remodeling that relates to white matter damage in aging, but molecular pathways underlying this association are unknown. This study assessed if LV mass index relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9a3a95e58b7c0c5cfb383ff42b4070
https://doi.org/10.1161/strokeaha.121.034349

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Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline

Autor: Timothy J. Hohman, Niranjana Shashikumar, Angela L. Jefferson, Kimberly R. Pechman, Elizabeth E. Moore, Bennett A. Landman, Logan Dumitrescu, Derek B. Archer, Katherine A. Gifford

Publikováno v: Neurobiol Aging

ObjectiveHippocampal volume is a sensitive marker of neurodegeneration and a well-established predictor of age-related cognitive impairment. Recently, free-water (FW) magnetic resonance imaging (MRI) has shown associations with pathology in Alzheimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39405f49c233748b9d5d814a35679227
https://doi.org/10.1016/j.neurobiolaging.2020.05.001

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The relationship between white matter microstructure and self-perceived cognitive decline

Autor: Bennett A. Landman, Angela L. Jefferson, Niranjana Shashikumar, Ujwala Pamidimukkala, Derek B. Archer, Katherine A. Gifford, Henrik Zetterberg, Timothy J. Hohman, Kaj Blennow, Elizabeth E. Moore, Kimberly R. Pechman

Publikováno v: NeuroImage : Clinical
NeuroImage: Clinical, Vol 32, Iss, Pp 102794-(2021)

Highlights • RDT within several white matter tracts is associated with SCD. • RDT contributes unique variance to SCD beyond that of CSF Aβ42. • Our findings suggest that RDT is a sensitive marker of SCD.
Subjective cognitive decline (SCD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e70ba2a44117b6965f541171a4efe17
https://pubmed.ncbi.nlm.nih.gov/34479171

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