Tunable intracellular transport on converging microtubule morphologies

Autor: Niranjan Sarpangala, Brooke Randell, Ajay Gopinathan, Oleg Kogan

Publikováno v: Biophysical Reports, Vol 4, Iss 3, Pp 100171- (2024)

A common type of cytoskeletal morphology involves multiple microtubules converging with their minus ends at the microtubule organizing center (MTOC). The cargo-motor complex will experience ballistic transport when bound to microtubules or diffusive

Externí odkaz: https://doaj.org/article/fc0aa3bd620f45ff8107d9f34af8a256

Active nematic order and dynamic lane formation of microtubules driven by membrane-bound diffusing motors

Autor: Fereshteh L. Memarian, Joseph D. Lopes, Fabian Jan Schwarzendahl, Madhuvanthi Guruprasad Athani, Niranjan Sarpangala, Ajay Gopinathan, Daniel A. Beller, Kinjal Dasbiswas, Linda S. Hirst

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 52
Proceedings of the National Academy of Sciences of the United States of America

Significance Active nematics are ordered liquid crystalline fluids that exhibit spontaneous persistent flows and collective dynamics. The development of motile biopolymer systems inspired by nature has recently attracted considerable attention to out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2de98985cc34083d645e5fd4892a2db
https://escholarship.org/uc/item/7d15j2hf

Cargo surface fluidity can reduce inter-motor mechanical interference, promote load-sharing and enhance processivity in teams of molecular motors

Autor: Ajay Gopinathan, Niranjan Sarpangala

Publikováno v: PLOS Computational Biology. 18:e1010217

In cells, multiple molecular motors work together as teams to carry cargoes such as vesicles and organelles over long distances to their destinations by stepping along a network of cytoskeletal filaments. How motors that typically mechanically interf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3758746825a515091b3bcce2d5ff36e3
https://doi.org/10.1371/journal.pcbi.1010217