Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Niranjan B. Pandey"'
Autor:
Natsuki Furukawa, Wendy Yang, Alex R. Chao, Akash Patil, Adam C. Mirando, Niranjan B. Pandey, Aleksander S. Popel
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide du
Externí odkaz:
https://doaj.org/article/535565cc213d4f06a93b1286166d686d
Autor:
Raquel Lima e Silva, Adam C. Mirando, Stephany Y. Tzeng, Jordan J. Green, Aleksander S. Popel, Niranjan B. Pandey, Peter A. Campochiaro
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106078- (2023)
Summary: AXT107, a collagen-derived peptide that binds integrins αvβ3 and α5β1 with high affinity, suppresses vascular endothelial growth factor (VEGF) signaling, promotes angiopoietin 2-induced Tie2 activation, and suppresses neovascularization
Externí odkaz:
https://doaj.org/article/78fca1949d7a467b812527971c29c555
Autor:
Quan Dong Nguyen, Jeffrey S. Heier, Diana V. Do, Adam C. Mirando, Niranjan B. Pandey, Huan Sheng, Theresa Heah
Publikováno v:
International Journal of Retina and Vitreous, Vol 6, Iss 1, Pp 1-11 (2020)
Abstract Background Retinal vascular diseases such as neovascular age-related macular degeneration, diabetic retinopathy and/or diabetic macular edema, and retinal vein occlusion with macular edema—share several key pathophysiologic aspects includi
Externí odkaz:
https://doaj.org/article/c73aeaa6d0eb4d789f62f0374180f918
Autor:
Adam C. Mirando, Akash Patil, Christine I. Rafie, Brian J. Christmas, Niranjan B. Pandey, Vered Stearns, Elizabeth M. Jaffee, Evanthia T. Roussos Torres, Aleksander S. Popel
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Triple-negative breast cancer (TNBC) is a highly metastatic and aggressive disease with limited treatment options. Recently, the combination of the immune checkpoint inhibitor (ICI) atezolizumab (anti-PD-L1) with nab-paclitaxel was approved following
Externí odkaz:
https://doaj.org/article/d7ce52b28cfc47f195f57a6014ece82b
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-10 (2018)
Abstract Background Metastatic triple-negative breast cancer (TNBC) is a heterogeneous and incurable disease. Numerous studies have been conducted to seek molecular targets to treat TNBC effectively, but chemotherapy is still the main choice for pati
Externí odkaz:
https://doaj.org/article/a0ca607effd5436c986e1e32c1e483e3
Autor:
Adam C. Mirando, Raquel Lima e Silva, Zenny Chu, Peter A. Campochiaro, Niranjan B. Pandey, Aleksander S. Popel
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 5142 (2020)
Persistent inflammation is a complication associated with many ocular diseases. Changes in ocular vessels can amplify disease responses and contribute to vision loss by influencing the delivery of leukocytes to the eye, vascular leakage, and perfusio
Externí odkaz:
https://doaj.org/article/b1f7088a53f64b59a1a90b18e7aad98b
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 2, Pp 112-124 (2013)
Angiogenesis, the formation of new blood vessels from preexisting blood vessels, is a process that supports tumor growth and metastatic dissemination. Lymphangiogenesis also facilitates metastasis by increasing dissemination through the lymphatic ves
Externí odkaz:
https://doaj.org/article/9146ae06be454874875f5d5246dcaaac
Autor:
Raquel Lima e Silva, Adam C. Mirando, Elana Ben-Akiva, Ron B. Shmueli, Peter A. Campochiaro, Jordan J. Green, Niranjan B. Pandey, Jayoung Kim, Aleksander S. Popel, Stephany Y. Tzeng
Publikováno v:
Acta Biomater
Leading causes of vision loss include neovascular age-related macular degeneration (NVAMD) and macular edema (ME), which both require frequent intravitreal injections for treatment. A safe, poly(lactic-co-glycolic acid) (PLGA)-based biodegradable pol
Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma
Autor:
Yu Zhang, Phuoc T. Tran, Aleksander S. Popel, Richard J. Sové, Ludmila Danilova, Elana J. Fertig, Mark Yarchoan, Adam C. Mirando, Mohammad Jafarnejad, Niranjan B. Pandey
Publikováno v:
npj Systems Biology and Applications, Vol 5, Iss 1, Pp 1-14 (2019)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
Hepatocyte growth factor (HGF) signaling through its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and progression. Met interaction with integrins is shown to modulate the downstream signaling to Akt and ERK (extracellula
Autor:
Niranjan B. Pandey, Adam C. Mirando, Jeffrey S. Heier, Diana V. Do, Theresa Heah, Quan Dong Nguyen, Huan Sheng
Publikováno v:
International Journal of Retina and Vitreous
International Journal of Retina and Vitreous, Vol 6, Iss 1, Pp 1-11 (2020)
International Journal of Retina and Vitreous, Vol 6, Iss 1, Pp 1-11 (2020)
Background Retinal vascular diseases such as neovascular age-related macular degeneration, diabetic retinopathy and/or diabetic macular edema, and retinal vein occlusion with macular edema—share several key pathophysiologic aspects including neovas