Výsledky vyhledávání - "Niramol, Savaraj"

Akademický článek

Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer

Autor: Chunjing Wu, Sydney A. Spector, George Theodoropoulos, Dan J. M. Nguyen, Emily Y. Kim, Ashley Garcia, Niramol Savaraj, Diane C. Lim, Ankita Paul, Lynn G. Feun, Michael Bickerdike, Medhi Wangpaichitr

Publikováno v: Cancer & Metabolism, Vol 11, Iss 1, Pp 1-22 (2023)

Abstract Background The impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum resistance. We have identified crucial metabolic differences between cisplatin-resistant (CR) and ci

Externí odkaz: https://doaj.org/article/a0383d87afed462586cb405c53f2010f

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Akademický článek

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Autor: Macus Tien Kuo, Yan Long, Wen-Bin Tsai, Ying-Ying Li, Helen H.W. Chen, Lynn G. Feun, Niramol Savaraj

Publikováno v: Translational Oncology, Vol 13, Iss 2, Pp 355-364 (2020)

Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular

Externí odkaz: https://doaj.org/article/2c25683ce0994692a0113e9213b5adda

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Akademický článek

Degradation of AMPK‐α1 sensitizes BRAF inhibitor‐resistant melanoma cells to arginine deprivation

Autor: Ying‐Ying Li, Chunjing Wu, Sumedh S. Shah, Shu‐Mei Chen, Medhi Wangpaichitr, Macus T. Kuo, Lynn G. Feun, Xiaoqing Han, Miguel Suarez, Jeffrey Prince, Niramol Savaraj

Publikováno v: Molecular Oncology, Vol 11, Iss 12, Pp 1806-1825 (2017)

Melanomas harboring BRAF mutation (V600E) are known to recur frequently following treatment with BRAF inhibitors (BRAFi) despite a high initial response rate. Our previous study has uncovered that BRAFi‐resistant melanoma (BR) cells are vulnerable

Externí odkaz: https://doaj.org/article/0ce0038e157442c390f27ac569a49769

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