Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Nirali N Shah"'
Autor:
Guenther Koehne, Benjamin Tomlinson, Hyung Suh, Divya Koura, Christina Cho, Nadia M Bambace, Léa Bernard, Nirali N Shah, Roland Walter, John Dipersio, Miguel-Angel Perales, Michael R Loken, Kyle Breitschwerdt, Sritama Nath, Glen Raffel, Brenda W Cooper
Publikováno v:
HemaSphere, Vol 7, p e24418bc (2023)
Externí odkaz:
https://doaj.org/article/fa33c02ba4ed4d2badc55a26e415090c
Autor:
Hannah Smith, Haneen Shalabi, Bonnie Yates, Nirali N Shah, Hao-Wei Wang, Terry J Fry, Dong Chen, Kevin Parker, Martin Ongkeko, Yanyu Wang, Jennifer Jess, Alina Dulau-Florea, Jon Inglefield, Dan Lichtenstein, Fiorella Schischlik, Shilpa Shahani, Ann Cullinane, Eli Kane, Lauren Little, Ansuman Satpathy, Jay Lozier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background Hematologic toxicities, including coagulopathy, endothelial activation, and cytopenias, with CD19-targeted chimeric antigen receptor (CAR) T-cell therapies correlate with cytokine release syndrome (CRS) and neurotoxicity severity, but litt
Externí odkaz:
https://doaj.org/article/67779dd2b8c74a5ebbccf3603b290777
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
The expansion and persistence of chimeric antigen receptor (CAR) T-cells in patients are associated with response, toxicity, and long-term efficacy. As such, the tools used to detect CAR T-cells following infusion are fundamental for optimizing this
Externí odkaz:
https://doaj.org/article/f9e49f10d3de42d1b40358e956a1a353
Autor:
Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/7341e3e04ef748e4ab7d4e2752aa2b98
Autor:
Aimee C Talleur, Brandon M Triplett, Haneen Shalabi, Bonnie Yates, Nirali N Shah, George Mo, Hao-Wei Wang, Michael G Douvas, Katherine R Calvo, Jack F Shern, Sridhar Chaganti, Katharine Patrick, Young Song, Terry J Fry, Xiaolin Wu, Javed Khan, Rebecca A Gardner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Immunotherapeutic strategies targeting B-cell acute lymphoblastic leukemia (B-ALL) effectively induce remission; however, disease recurrence remains a challenge. Due to the potential for antigen loss, antigen diminution, lineage switch or development
Externí odkaz:
https://doaj.org/article/9165dfbe9bda40b7991cff5cb81c8857
Autor:
Kenneth Cornetta, Jing Yao, Kimberley House, Lisa Duffy, Prasad S. Adusumilli, Rachel Beyer, Claire Booth, Malcolm Brenner, Kevin Curran, Bambi Grilley, Helen Heslop, Christian S. Hinrichs, Rosandra N. Kaplan, Hans-Peter Kiem, James Kochenderfer, Donald B. Kohn, Sham Mailankody, Scott M. Norberg, Roisin E. O'Cearbhaill, Jennifer Pappas, Jae Park, Carlos Ramos, Antonio Ribas, Isabelle Rivière, Steven A. Rosenberg, Craig Sauter, Nirali N. Shah, Susan F. Slovin, Adrian Thrasher, David A. Williams, Tsai-Yu Lin
Publikováno v:
Molecular Therapy. 31:801-809
The clinical impact of any therapy requires the product be safe and effective. Gammaretroviral vectors pose several unique risks, including inadvertent exposure to replication competent retrovirus (RCR) that can arise during vector manufacture. The U
Autor:
Aiman J. Faruqi, John A. Ligon, Paul Borgman, Seth M. Steinberg, Toni Foley, Lauren Little, Crystal L. Mackall, Daniel W. Lee, Terry J. Fry, Haneen Shalabi, Jennifer Brudno, Bonnie Yates, Lekha Mikkilineni, James Kochenderfer, Nirali N. Shah
Publikováno v:
Blood Advances. 6:6040-6050
Cancer outcomes with chemotherapy are inferior in patients of minority racial/ethnic groups and those with obesity. Chimeric antigen receptor (CAR) T-cell therapy has transformed outcomes for relapsed/refractory hematologic malignancies, but whether
Autor:
Akshay Sharma, Stephanie Farnia, Folashade Otegbeye, Amy Rinkle, Jugna Shah, Nirali N. Shah, Saar Gill, Marcela V. Maus
Publikováno v:
Transplantation and Cellular Therapy. 28:795-801
Autor:
Rebecca A. Gardner, Nirali N. Shah
Publikováno v:
Journal of Clinical Oncology. 41:1646-1648
Publikováno v:
Cell
Cell Res
Cell Res
Regulatable CAR platforms could circumvent toxicities associated with CAR-T therapy, but existing systems have shortcomings including leakiness and attenuated activity. Here, we present SNIP CARs, a protease-based platform for regulating CAR activity