Zobrazeno 1 - 10
of 362
pro vyhledávání: '"Nirali N Shah"'
Autor:
Michaela Prochazkova, Alexandra Dreyzin, Lipei Shao, Pam Garces, Yihua Cai, Rongye Shi, Alejandra Pelayo, Yong Soo Kim, Victoria Pham, Sue Ellen Frodigh, Shannon Fenton, Catherine Karangwa, Yan Su, Kathryn Martin, Nan Zhang, Steven L. Highfill, Robert P. Somerville, Nirali N. Shah, David F. Stroncek, Ping Jin
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Chimeric antigen receptor (CAR) T-cells have demonstrated significant efficacy in targeting hematological malignancies, and their use continues to expand. Despite substantial efforts spent on the optimization of protocols for CAR
Externí odkaz:
https://doaj.org/article/e76402ef6dbc4cf19d5cc3bcdffbfcd6
Autor:
Jack J. Scala, Michael J. Eckrich, Keagan Lipak, Bonnie Yates, Constance Yuan, Hao-Wei Wang, Saurabh Dahiya, Jan-Inge Henter, Jeffrey S. Huo, Matthew J. Frank, Nirali N. Shah
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/8474808afc2e4128abfe0545d3777d57
Autor:
Hannah W. Song, Mehdi Benzaoui, Alka Dwivedi, Sarah Underwood, Lipei Shao, Sooraj Achar, Vesna Posarac, Victoria A. Remley, Michaela Prochazkova, Yihua Cai, Ping Jin, Robert P. Somerville, David F. Stroncek, Grégoire Altan-Bonnet, Nirali N. Shah, Christopher D. Chien, Naomi Taylor, Steven L. Highfill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101171- (2024)
Chimeric antigen receptor T cells (CART) have demonstrated curative potential for hematological malignancies, but the optimal manufacturing has not yet been determined and may differ across products. The first step, T cell selection, removes contamin
Externí odkaz:
https://doaj.org/article/e203f324125d46899b74298138fef026
Autor:
Alexandra Dreyzin, Sandhya R. Panch, Haneen Shalabi, Bonnie Yates, Steven L. Highfill, Ping Jin, David Stroncek, Nirali N. Shah
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 51-61 (2023)
Cryopreservation of chimeric antigen receptor (CAR) T cells facilitates shipment, timing of infusions, and storage of subsequent doses. However, reports on the impact of cryopreservation on CAR T cell efficacy have been mixed. We retrospectively comp
Externí odkaz:
https://doaj.org/article/b7798ef47ea843b29b8ef539a38ccb2c
Autor:
Guenther Koehne, Benjamin Tomlinson, Hyung Suh, Divya Koura, Christina Cho, Nadia M Bambace, Léa Bernard, Nirali N Shah, Roland Walter, John Dipersio, Miguel-Angel Perales, Michael R Loken, Kyle Breitschwerdt, Sritama Nath, Glen Raffel, Brenda W Cooper
Publikováno v:
HemaSphere, Vol 7, p e24418bc (2023)
Externí odkaz:
https://doaj.org/article/fa33c02ba4ed4d2badc55a26e415090c
Autor:
Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin, David F. Stroncek
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Clinical CAR T-cell therapy using integrating vector systems represents a promising approach for the treatment of hematological malignancies. Lentiviral and γ-retroviral vectors are the most commonly used vectors in the manufactu
Externí odkaz:
https://doaj.org/article/32a010a258d84ef0bd9faf982f28cee6
Autor:
Hannah Smith, Haneen Shalabi, Bonnie Yates, Nirali N Shah, Hao-Wei Wang, Terry J Fry, Dong Chen, Kevin Parker, Martin Ongkeko, Yanyu Wang, Jennifer Jess, Alina Dulau-Florea, Jon Inglefield, Dan Lichtenstein, Fiorella Schischlik, Shilpa Shahani, Ann Cullinane, Eli Kane, Lauren Little, Ansuman Satpathy, Jay Lozier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background Hematologic toxicities, including coagulopathy, endothelial activation, and cytopenias, with CD19-targeted chimeric antigen receptor (CAR) T-cell therapies correlate with cytokine release syndrome (CRS) and neurotoxicity severity, but litt
Externí odkaz:
https://doaj.org/article/67779dd2b8c74a5ebbccf3603b290777
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
The expansion and persistence of chimeric antigen receptor (CAR) T-cells in patients are associated with response, toxicity, and long-term efficacy. As such, the tools used to detect CAR T-cells following infusion are fundamental for optimizing this
Externí odkaz:
https://doaj.org/article/f9e49f10d3de42d1b40358e956a1a353
Autor:
Lipei Shao, Alejandra Pelayo, Rongye Shi, Jinxia Ma, Hui Liu, Yihua Cai, Michaela Prochazkova, Robert P. Somerville, Sandhya R. Panch, Nirali N. Shah, David F. Stroncek, Ping Jin
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Cytokine release syndrome (CRS) is a strong immune system response that can occur as a result of the reaction of a cellular immunotherapy with malignant cells. While the frequency and management of CRS in CAR T-cell therapy has be
Externí odkaz:
https://doaj.org/article/af570cabca00431987eddf5ab674ba25
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Novel immunotherapies are increasingly being employed in pediatric oncology, both in the upfront and relapsed/refractory settings. Through various mechanisms of action, engagement and activation of the immune system can cause both generalized and dis
Externí odkaz:
https://doaj.org/article/39ab8e4b9c4442fdba2e85d9d25ac9e5