Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Niraj S. Trasi"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100052- (2020)
Amorphous solid dispersions (ASDs) of lumefantrine, which has low aqueous solubility, have been shown to improve bioavailability relative to crystalline formulations. Herein, the crystallization tendency and release properties of a variety of lumefan
Externí odkaz:
https://doaj.org/article/92f7ad4eeab44655b464207f3a51a8c3
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
Herein, we evaluate the potential of using a simple solvent granulation process to prepare a binary drug amorphous solid dispersion (ASD) containing two anti-HIV drugs, ritonavir and lopinavir. The drugs were granulated onto a mixture of lactose and
Externí odkaz:
https://doaj.org/article/b0fd22eac2d5484a8341ad5cc3c873bf
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 3, Pp o591-o591 (2012)
The crystal structure of nilutamide [systematic name: 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione], C12H10F3N3O4, was determined at 150 K. The dihedral angle between the mean planes through the imidazoline [maximum devia
Externí odkaz:
https://doaj.org/article/3c8b968e9f4a4226bc1428870f34c6d0
Autor:
Niraj S. Trasi, Hitesh S. Purohit, Geoff G. Z. Zhang, Lynne S. Taylor, Wenqing Gao, DeAnne Stolarik, Gary J. Jenkins, Donald J. Osterling
Publikováno v:
Molecular Pharmaceutics. 16:3617-3625
Crystallization of drug from an amorphous formulation is expected to negatively impact its bioperformance following oral delivery. In evaluating this in vivo, neat crystalline drug is typically mixed with the amorphous formulation. However, this appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf28227f158c5849435503fe5b8cb7a
https://doi.org/10.1021/acs.molpharmaceut.9b00455
https://doi.org/10.1021/acs.molpharmaceut.9b00455
Autor:
Lynne S. Taylor, Elise Miller, Patrick J. Marsac, Niraj S. Trasi, Narayan Variankaval, Clara Correa-Soto, Garth J. Simpson, Paul D. Schmitt, Yongchao Su, Zhen Liu
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 146:86-95
Various techniques have been used to detect crystallization in amorphous solid dispersions (ASD). However, most of these techniques do not enable the detection of very low levels of crystallinity (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6019cf141bcbbff06e00edf6bb28af33
https://doi.org/10.1016/j.jpba.2017.07.066
https://doi.org/10.1016/j.jpba.2017.07.066
Publikováno v:
Journal of Pharmaceutical Sciences. 106:264-272
An increasing number of drugs with low aqueous solubility are being formulated and marketed as amorphous solid dispersions because the amorphous form can generate a higher solubility compared to the crystalline solid. The amorphous solubility of a dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e70aa27ab34e37b44c07c06bcb762d
https://doi.org/10.1016/j.xphs.2016.09.016
https://doi.org/10.1016/j.xphs.2016.09.016
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss, Pp 100052-(2020)
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X
Amorphous solid dispersions (ASDs) of lumefantrine, which has low aqueous solubility, have been shown to improve bioavailability relative to crystalline formulations. Herein, the crystallization tendency and release properties of a variety of lumefan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a524444c0541f066f9d5a4db2c8ccf35
https://doi.org/10.1016/j.ijpx.2020.100052
https://doi.org/10.1016/j.ijpx.2020.100052
Publikováno v:
Molecular Pharmaceutics. 12:2378-2383
Second harmonic generation (SHG) microscopy was used to rapidly identify regions of interest for localized confocal Raman spectroscopy measurements in order to quantify crystallinity within lyophilized Abraxane powder (protein bound paclitaxel for in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c572b23f1c66b7c79832e6a5f398a6a0
https://doi.org/10.1021/acs.molpharmaceut.5b00065
https://doi.org/10.1021/acs.molpharmaceut.5b00065
Autor:
Irene A. George, Lynne S. Taylor, Niraj S. Trasi, Shane Z. Sullivan, Scott J. Toth, Greg R. Snyder, Garth J. Simpson, Paul D. Schmitt
Publikováno v:
Crystal Growth & Design. 15:581-586
A model for predicting the anticipated second harmonic generation (SHG) activity of crystalline active pharmaceutical ingredients (APIs) was developed based on combining time-dependent Hartree–Fock calculations of the molecular building block with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5944c1a1629f114c9727d827a65a70e
https://doi.org/10.1021/acs.cgd.5b00020
https://doi.org/10.1021/acs.cgd.5b00020
Publikováno v:
CrystEngComm. 17:1242-1248
The nucleation behaviour of supersaturated acetaminophen was studied in the presence and absence of pharmaceutical polymers. Two different techniques involving turbidimetry and particle count analysis were used. Poly(vinylpyrrolidone) and the cellulo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e94c2ded5015eecb685191b74a6cab1d
https://doi.org/10.1039/c4ce02179g
https://doi.org/10.1039/c4ce02179g