Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Niraj K. Naikade"'
Autor:
Sunil K. Puri, Mohit K. Tiwari, Niraj K. Naikade, Sandeep Chaudhary, Bharti Rajesh Kumar Shyamlal, Lalit Yadav
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1536-1541
A new series of ester analogues of artemisinin 8a-f, incorporating diphenylmethyl as pharmacologically privileged substructure, and 8g-j have been prepared and evaluated for their antimalarial activity against multidrug-resistant (MDR) Plasmodium yoe
Autor:
Niraj K. Naikade, Sandeep Chaudhary, Mohit K. Tiwari, Bharti Rajesh Kumar Shyamlal, Ajit K. Swami, Manas Mathur, Lalit Yadav, Sunil Kumar Puri
Publikováno v:
RSC Advances. 6:23718-23725
For the first time, novel bicyclic 5a–h as well as tricyclic 9a–h aza-peroxides were synthesized using a 1O2-mediated photo-oxygenation methodology as a key step in 52–71% yields in which one of the oxygen atoms of the 1,2,4-trioxane ring has b
Autor:
Mohammad Hassam, Ved Prakash Verma, Ajit Shankar Singh, Chandan Singh, Sunil K. Puri, Niraj K. Naikade
Publikováno v:
Journal of Medicinal Chemistry. 57:2489-2497
By use of artemisinin 1 as the starting material, two new amino- and hydroxy-functionalized 11-azaartemisinins 9 and 11 and their derivatives 12a-g, 13a-g, 14a-g, and 15a-c have been prepared and screened for antimalarial activity by oral route again
Autor:
Manas Mathur, Ajit K. Swami, Bharti Rajesh Kumar Shyamlal, Niraj K. Naikade, Lalit Yadav, Sandeep Chaudhary, Sunil Kumar Puri, Mohit K. Tiwari
Publikováno v:
ChemInform. 47
The title peroxides are prepared using a 1O2-mediated photo-oxygenation method as a key step.
Autor:
Sanjeev K. Shukla, Niraj K. Naikade, Prem P. Yadav, Makthala Ravi, Ranjani Maurya, Parul Chauhan, Devireddy Anand
Publikováno v:
Synlett. 24:173-176
A facile and efficient method for the synthesis of 1,2,4-trioxepanes and 1,2,4-trioxanes from different carbinols having cyclopropyl and phenyl substituents has been developed. The corresponding hydroxyhydroperoxides were synthesized from 30% H 2 O 2
Autor:
Niraj K. Naikade, Prakas R. Maulik, Mohammad Hassam, Ruchir Kant, Ved Prakash Verma, Sunil K. Puri, Ajit Shankar Singh, Chandan Singh
Publikováno v:
Journal of Medicinal Chemistry. 55:10662-10673
A new series of bile acid-based trioxanes 23a-d, 24a-d, 25a-d, 26a, 26b, and 26d have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. The antimalarial activity o
Autor:
Niraj K. Naikade, Shilpi Pandey, Ved Prakash Verma, Mohammad Hassam, Nitin Gupta, Ajit Shankar Singh, Chandan Singh
Publikováno v:
Synthesis. 2010:1014-1022
The utility of a hydrazinium carbazate (N 2 H 3 COON 2 H 5 ) andH 2 O 2 combination for the double bond reductionof base-sensitive unsaturated 1,2,4-trioxanes, 1,2,4-trioxepanes,and their precursors β- and γ-hydroxyhydroperoxidesis presented. The m
Autor:
Ved Prakash Verma, Ajit Shankar Singh, Sunil K. Puri, Chandan Singh, Mohammad Hassam, Niraj K. Naikade
Publikováno v:
Journal of Medicinal Chemistry. 51:7581-7592
A new series of bis-1,2,4-trioxanes 12a-h, 13a-h, and 14a-h and tris-1,2,4-trioxanes 12i-14i were prepared and evaluated against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. Cyclopentane-based bis-trioxanes 12a, 12b, 12f-h and c
Autor:
Chandan, Singh, Ved Prakash, Verma, Mohammad, Hassam, Ajit Shankar, Singh, Niraj K, Naikade, Sunil K, Puri
Publikováno v:
Journal of medicinal chemistry. 57(6)
By use of artemisinin 1 as the starting material, two new amino- and hydroxy-functionalized 11-azaartemisinins 9 and 11 and their derivatives 12a-g, 13a-g, 14a-g, and 15a-c have been prepared and screened for antimalarial activity by oral route again
Autor:
Sanjeev K. Shukla, Makthala Ravi, Niraj K. Naikade, Ranjani Maurya, Parul Chauhan, Prem P. Yadav, Devireddy Anand
Publikováno v:
ChemInform. 44
A convenient two-step sequence allows the synthesis of the target compounds from carbinols via oxidation and subsequent condensation of the resulting hydroperoxides with ketones.