Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nira Bar-Ner"'
Publikováno v:
Chemico-biological interactions. 259
The antidotal treatment of organophosphates (OP) nerve agents (NA) poisoning is based on anticholinergics (e.g. atropine) combined with oxime reactivators (e.g. 2PAM) of acetylcholinesterase (AChE). This treatment is symptomatic and does not degrade
Autor:
Niva Natan, Lili Wu, Victoria Nahum, Abraham Fisher, Eitan Gershonov, Nira Bar-Ner, Hanoch Elkon, Rodrigo Medeiros, Frank M. LaFerla, Ilya Bezprozvanny, Daniel A. Ryskamp, Rachel Brandeis
Publikováno v:
Fisher, Abraham; Bezprozvanny, Ilya; Wu, Lili; Ryskamp, Daniel A; Bar-Ner, Nira; Natan, Niva; et al.(2016). AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease.. Neuro-degenerative diseases, 16(1-2), 95-110. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/0rm238hc
We previously developed orthosteric M1 muscarinic agonists (e.g. AF102B, AF267B and AF292), which act as cognitive enhancers and potential disease modifiers. We now report on a novel compound, AF710B, a highly potent and selective allosteric M1 musca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c808f1fecaeec6a83b471e4875eadfe
https://europepmc.org/articles/PMC4803577/
https://europepmc.org/articles/PMC4803577/
Autor:
Niva Natan, Nira Bar-Ner, Itzhak Marcovitch, Hagar Sonego, Rachel Brandeis, Abraham Fisher, Zipora Pittel, Rachel Haring, Inbal Egozi, Michal Kliger-Spatz
Publikováno v:
Journal of Molecular Neuroscience. 20:349-356
M1 muscarinic receptors (M1 mAChRs) play a role in an apparent linkage of three major hallmarks of Alzheimer's disease (AD): beta-amyloid (Abeta) peptide; tau hyperphosphorylation and paired helical filaments (PHFs); and loss of cholinergic function
Autor:
Niva Natan, Itzhak Marcovitch, Rachel Haring Nira Bar-Ner, Hagar Sonego, Michal Kliger-Spatz, Abraham Fisher, Rachel Brandeis, Zipora Pittel
Publikováno v:
Journal of Molecular Neuroscience. 19:145-153
The M1 muscarinic agonists AF102B (Cevimeline, EVOXACTM: prescribed in USA and Japan for Sjogren's Syndrome), AF150(S) and AF267B--1) are neurotrophic and synergistic with neurotrophins such as nerve growth factor and epidermal growth factor; 2) elev
Autor:
Nira Bar-Ner, Frank M. LaFerla, Niva Natan, Victoria Nahum, Gayane Grigoryan, Abraham Fisher, Menahem Segal, Rodrigo Medeiros, Hanoch Elkon, Rachel Brandeis
Publikováno v:
Alzheimer's & Dementia. 10
Autor:
Orli Eisenberg, Yishai Karton, Daniele Marciano, Rachel Haring, Abraham Fisher, Zipora Pittel, Rachel Brandeis, Haim Meshulam, Eliahu Heldman, Nira Bar-Ner, Naomi Eshhar
Publikováno v:
Journal of Physiology-Paris. 92:337-340
M1 selective agonists from the AF series (e.g. AF102B, AF150(S)), via m1 muscarinic receptors, activate distinct signal transductions, enhance amyloid precursors proteins secretion from transfected cells and primary cell cultures, show neurotrophic e
Publikováno v:
The Journal of Organic Chemistry. 61:7116-7124
Thiol-mediated free radical isomerization of a deliberately substituted but-3-enyl isocyanide 12a, and n-Bu(3)SnH/AIBN-mediated free radical cyclization of a deliberately substituted but-3-enyl isothiocyanate 22, afforded, respectively, the (ethylthi
Autor:
Abraham Fisher, Alon Rabinovich, Nira Bar-Ner, Daniel A. Ryskamp, Dan Frenkel, Frank M. LaFerla, Niva Natan, Rodrigo Mederios, Ilya Bezprozvanny, Rachel Brandeis, Hanoch Elkon, Eitan Gershonov
Publikováno v:
Neurobiology of Aging. 39:S5
Publikováno v:
The Journal of Organic Chemistry. 59:7752-7758
Publikováno v:
Pure and Applied Chemistry. 65:595-601
Various non-aromatic heterocyclic compounds, including lactones, lactams,thiolactams, chromanones and pyrrolines are obtained by reactions involving the intramolecular addition of carbon-centered ene radicals to carbon-carbon multiple bonds